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Author: Tsuneo Fujita
Publisher:
ISBN:
Category : Alimentary canal
Languages : en
Pages : 214
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Book Description
"The majority of the chapters of this volume are based on the papers read in a Symposium on the "GEP Endocrine System" held on 11 and 12 February, 1972, at Ikaho, Japan."
Author: Tsuneo Fujita
Publisher:
ISBN:
Category : Alimentary canal
Languages : en
Pages : 214
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Book Description
"The majority of the chapters of this volume are based on the papers read in a Symposium on the "GEP Endocrine System" held on 11 and 12 February, 1972, at Ikaho, Japan."
Author: Tsuneo Fujita
Publisher: Springer Science & Business Media
ISBN: 4431680667
Category : Medical
Languages : en
Pages : 373
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Book Description
The regulation of the organism has traditionally been ascribed to two distinct systems-the nervous and the endocrine. Though coordination between the two systems has been acknowledged, researchers and authors have tended to deal with them as comprising separate categories of cells involved in different activities. With this approach, a given regulatory mechanism would be evaluated as to whether it should be accounted for by nervous or endocrine functions. The past 15 years, however, have witnessed numerous important discoveries and conceptual developments concerning the morphological, physiological, and bio chemical relations between the nervous and endocrine systems. Advances in im munocytochemical studies have revealed that there are a wide variety of messenger substances that function in both regulatory systems. As a result, researchers have been stimulated to investigate neuronlike properties of endocrine cells and, con versely, endocrine or secretory features of neurons. It has thus become obvious that the rigidities in the classic criteria of neurotransmitters and hormones may rather impede further advances in these research fields. The activities of neurons are no longer evaluated simply in terms of EPSP, IPSP, and the release of classic trans mitters such as acetylcholine, noradrenaline, and GABA. Hormonal actions are no longer analyzed solely with regard to concentrations of classic aminic and peptidic hormones in the systemic blood circulation. The concept of the paraneuron, which we proposed in 1975, has become one of the theoretical bases for the development of this trend of study.
Author: Tsuneo Fujita
Publisher: Elsevier Science & Technology
ISBN:
Category : Gastrointestinal hormones
Languages : en
Pages : 436
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Book Description
Author: Yogeshwar Dayal
Publisher: CRC Press
ISBN: 9780849359934
Category : Medical
Languages : en
Pages : 352
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Book Description
This important new book presents critical information on the clinical and morphological aspects of various endocrinological disorders of the gut and pancreas. Topics include a historical perspective and broad overview of the neuroendocrine component of the gut; hyperplastic proliferations of gastrointestinal endocrine cells; pancreatic endocrine cells and their non-neoplastic proliferations; tumors and lesions; and endocrine differentiation in nonendocrine tumors. The book stresses clinical and pathological aspects of these topics, as well as the pathogenesis, clinicopathological correlations, and diagnostic approaches. Gastroenterologists, pathologists, internists, surgeons, endocrinologists and others interested in endocrinological disorders of the gut and pancreas will discover that this book will be a welcome addition to your reference library.
Author: Stephen Pandol
Publisher: Morgan & Claypool Publishers
ISBN: 1615041389
Category : Medical
Languages : en
Pages : 66
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Book Description
The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
Author: Joseph R. Pisegna
Publisher: Springer
ISBN: 1493917986
Category : Medical
Languages : en
Pages : 175
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Book Description
This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.
Author: T.M. O'Dorisio
Publisher: Springer Science & Business Media
ISBN: 3642613284
Category : Medical
Languages : en
Pages : 296
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Book Description
The secretion of bioactive products by tumors of the gastroenteropancreatic system results in the development of watery diarrhea that can lead to death in a very short period if not brought under control. Even if the consequences are less dramatic, the patients' ability to lead a normal daily life is seriously impaired, and they may become severely depressed. SandostatinR alleviates the condition by inhibiting peptide release, and its long duration of action makes it an effective and rational adjunct to therapy at all stages. Last year a consensus Round Table Meeting was held in Scottsdale, Arizona, to discuss the optimal use of SandostatinR in this indication. These guidelines offer the results of clinical research and the dosage recommendations arising from them, together with a critical summary of the points of view presented.
Author: M.V. Singer
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 652
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Book Description
Increasing knowledge of the interaction of the endocrine system and the gastrointestinal tract leads to improved insight into the mutual control of the GI and endocrine functions, as well as in the aetiology and pathogenesis of various diseases and into new therapeutic approaches. This book, the proceedings of the 177th Falk Symposim held in Freiburg, Germany, 12-14 June, 1994, presents a unified view of clinical and basic research, especially neurophysiology, neuroendocrinology, behavioural sciences, morphology, pharmacology, gastrointestinal and endocrine physiology and pathophysiology, surgery, gastroenterology and endocrinology. Current knowledge is discussed, communication between separate disciplines assisted, and new research suggested.
Author: Stephen Robert Bloom
Publisher:
ISBN:
Category : Gastrointestinal hormones
Languages : en
Pages : 640
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Book Description
Author: Georgios S. Limouris
Publisher: Springer Nature
ISBN: 3030707733
Category : Medical
Languages : en
Pages : 265
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Book Description
This book describes in detail a clinical project that reveals the tumoricidal efficacy of Auger and internal conversion electrons, emitted from n.c.a. 111In and implemented in oncology as a treating armamentarium for peptide receptor radionuclide therapy (PRRT), targeting small size (ø ≤ 20 mm) tumors and micro-metastases. The keen interest in n.c.a. 111In began when it was observed that its Auger electron emission could be highly radiotoxic, due to its high LET when it decayed in the vicinity of cellular DNA. The somatostatin analog octreotide, labeled with [111In-diethylenetriaminepentaacetic acid (DTPA0-D-Phe1)] is an established diagnostic agent for the imaging of somatostatin receptor-positive neuro- (or non-neuro) endocrine tumors. It relies on receptor-mediated binding, internalization and installation in the lysosomes in the proximity of the nucleus; administered in large doses, loco-regionally, via the feeding artery of solid tumors, can be highly radiotoxic if they over-express somatostatin receptors, mainly of the sst2 histotype. The book compares the results between i.v. and i.a. implementation in more than 80 patients after over 800 i.a. infusions in neuroendocrine tumors, meningiomas, paragangliomas and colorectal carcinomas in a single Institute (Aretaieion University Hospital) and encourages the i.a. way, leading to “tumor melting”, while minimizing the toxicity to healthy peritumoral liver tissue and critical organs (kidneys and bone marrow). The volume is an invaluable tool for nuclear medicine physicians, interventional radiologists and oncologists dealing with radiopeptide therapies.
