Author:
Publisher: Academic Press
ISBN: 0123869528
Category : Science
Languages : en
Pages : 403
Get Book Here
Book Description
Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans. Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant potential as new anti-obesity drugs Chapters are written by leading experts
Author: Université Laval. Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie and Universite Laval
Publisher:
ISBN:
Category : G proteins
Languages : en
Pages : 44
Get Book Here
Book Description
Author: G. Ühbeck
Publisher: CABI
ISBN: 1845934318
Category : Energy metabolism
Languages : en
Pages : 412
Get Book Here
Book Description
Obesity is one of the relevant public health concerns and it is evident that body weight control is achieved through highly integrated physiological interactions like nutrient selection. Presenting an account of the roles of specific peptides in energy balance, this title provides an understanding of the patho-physiology of energy balance.
Author: Madelaine D. Russell
Publisher:
ISBN:
Category : G proteins
Languages : en
Pages : 0
Get Book Here
Book Description
Energy homeostasis is a dynamic and complex process that maintains a balance between energy intake and expenditure. G protein coupled receptors (GPCRs), the largest family of transmembrane receptors, are critical for the cellular communication needed to coordinate processes involved in energy homeostasis (e.g. food intake). Indeed, metabolites are thought to act as sensors of energy stores by activating GPCRs in order to regulate energy homeostasis. Amino acids in particular have been shown to activate a growing number of GPCRs such as the calcium receptor (CaR), the orphan GPCRs GPR142 and GPR139, the purinergic receptor P2Y, and the hydroxycarboxylic acid receptor HCA3. This study aimed to further elucidate the role of monomeric amino acids as signaling molecules by employing a high throughput screen approach in which 19 monomeric amino acids were screened against 72 lipid metabolism GPCRs in a human cell line. Receptor activity was measured using the G-protein independent ?-arrestin recruitment PRESTO TANGO assay. It was found that a mixture of 19 essential and non-essential amino acids significantly activated 14 lipid metabolism GPCRs. Of these, MC4, DP2, GPBA, S1P1, and S1P4 were chosen for further investigation and were found to be significantly activated by 0.8 mM L-Phenylalanine. This finding suggests L-Phenylalanine may play a more prominent role as a signalling molecule at GPCRs regulating energy homeostasis than previously thought. This aids in elucidating the satiating mechanisms of high protein diets and has important implications for research into diseases such as obesity, type 2 diabetes, and the metabolic syndrome.
Author: 李倩祈
Publisher:
ISBN:
Category : G proteins
Languages : en
Pages : 62
Get Book Here
Book Description
Author: Tobias Langenhan
Publisher: Springer
ISBN: 3319415239
Category : Medical
Languages : en
Pages : 409
Get Book Here
Book Description
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
Author: Stephen Robert Bloom
Publisher:
ISBN:
Category : Gastrointestinal hormones
Languages : en
Pages : 640
Get Book Here
Book Description
Author: Antje Hebestreit
Publisher: MDPI
ISBN: 3039216007
Category : Medical
Languages : en
Pages : 358
Get Book Here
Book Description
In recent years, diet- and lifestyle-related disorders have become a major health threat in Europe and worldwide. The contributions in this monograph include 2 review articles and 19 original contributions from several countries that provide new information on the existing research elucidating important aspects of children’s and adolescents’ nutrition and lifestyle behavior. The data included in this Special Issue are from large epidemiological studies, including several multicenter and multinational studies, as well as datasets from surveillance initiatives. The topics of interest of this Special Issue include the co-occurrence of multiple health behaviors in children, the role of parenting and early feeding practices, dairy consumption in childhood, validity of dietary intake data, dietary supplement use in children, as well as socioeconomic disparities and eating culture. The diverse articles in this Special Issue highlight the complexity and extent to which nutrition and physical activity behaviors may influence different health aspects of children and adolescents. As seen by the various findings and recommendations, not only is more work in this area required but the translation of this work to practice and policy is imperative if we are to address the challenges impacting the nutrition, physical activity, and health of young populations.
Author: Claude Bouchard
Publisher: CRC Press
ISBN: 1000141608
Category : Medical
Languages : en
Pages : 262
Get Book Here
Book Description
This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.
Author: Frank P. Brooks
Publisher:
ISBN:
Category : Endocrine glands
Languages : en
Pages : 416
Get Book Here
Book Description
