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Author: Yupeng Shi
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Silica nanoparticles, thanks to the great easy and adaptability of particle synthesis and limited biotoxicity, is very widely studied for biomedical applications. This thesis conducted a large diversity of investigations involving silica nanomaterials. Firstly, the physicochemical properties and biodegradation properties of three types of structured silica nanoparticles were studied in a buffer, a culture medium and in contact with human dermal fibroblasts that suggest that, under these conditions, the silica nanoparticles must be mainly considered as degraded by hydrolysis and not biodegraded. Then, multifunctional silica nanoparticles which are consist of hollow silica nanoparticles and MnO2 nanosheets were synthesized. And the control drug release and imaging performance of this nanoplatforms were studied from 2D to 3D models. This approach could be used for a rapid assessment of the biofunctionality of nanoparticles before setting up in vivo experiments. Furthermore, a new 3D collagen-based nanocomposites using silica rods were studied and the relationships between the composite composition, structure and mechanical properties, emphasizing the key role of collagen-silica interactions. The influence of these parameters on the adhesion and proliferation of fibroblast cells was also investigated. In addition, we prepared and used magnetic silica nanorods to control particle orientation within the collagen network thanks to an external magnetic field. All the results bring new insights on the preparation and properties of bionanocomposites and open the route to multifunctional hydrogels.
Author: Yupeng Shi
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Silica nanoparticles, thanks to the great easy and adaptability of particle synthesis and limited biotoxicity, is very widely studied for biomedical applications. This thesis conducted a large diversity of investigations involving silica nanomaterials. Firstly, the physicochemical properties and biodegradation properties of three types of structured silica nanoparticles were studied in a buffer, a culture medium and in contact with human dermal fibroblasts that suggest that, under these conditions, the silica nanoparticles must be mainly considered as degraded by hydrolysis and not biodegraded. Then, multifunctional silica nanoparticles which are consist of hollow silica nanoparticles and MnO2 nanosheets were synthesized. And the control drug release and imaging performance of this nanoplatforms were studied from 2D to 3D models. This approach could be used for a rapid assessment of the biofunctionality of nanoparticles before setting up in vivo experiments. Furthermore, a new 3D collagen-based nanocomposites using silica rods were studied and the relationships between the composite composition, structure and mechanical properties, emphasizing the key role of collagen-silica interactions. The influence of these parameters on the adhesion and proliferation of fibroblast cells was also investigated. In addition, we prepared and used magnetic silica nanorods to control particle orientation within the collagen network thanks to an external magnetic field. All the results bring new insights on the preparation and properties of bionanocomposites and open the route to multifunctional hydrogels.
Author: Hector Nuño
Publisher:
ISBN:
Category : Biosensors
Languages : en
Pages : 144
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Book Description
This work covers both two dimensional (2D) and three dimensional (3D) silica-based nanostructures for use in biomedical sensing applications. The first section of this study discusses the formation of 2D nanostructured surface plasmon resonance (SPR)-based biosensor substrates. The surface of these biosensors was nanostructured by adding sacrificial star polymers or block copolymers to a silicate precursor solution. Subsequent vitrification resulted in two distinct morphological patterns: random and ordered porosity. Amino groups on the surface of the biosensors enabled the installation of analyte receptors and antifouling agents such as oligo (ethylene oxide). The second section discusses the development of 3D core-shell silica nanoparticles (SNPs). For this work, star polymers were generated to provide hydrophobic interiors capable of sequestering large hydrophobic porphyrinoid dyes and hydrophilic exteriors capable of templating the growth of silica shells. The diameter of the SNPs (25-100 nm) varied depending on reaction time, template size, and reagent concentration. The shell thickness was also controlled in order to either release or retain the hydrophobic dyes. The SNPs were surface-functionalized with biocompatible "stealth" materials such as poly (ethylene oxide) to generate non-toxic, water-soluble nanoparticles for the in vivo delivery of various hydrophobic imaging and therapeutic materials.
Author: Nathan Isaac Walton
Publisher:
ISBN:
Category : Nanoparticles
Languages : en
Pages : 100
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Book Description
Author: Gary W. VanLoon
Publisher: Oxford University Press, USA
ISBN: 9780198564409
Category : Science
Languages : en
Pages : 492
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Book Description
This is a comprehensive textbook for upper level undergraduates which discusses the nature of heterogeneous systems in the natural environment. The links between and within the various environmental compartments - air, water, soil - are emphasized. The book describes the chemistry of natural systems, their composition and the processes and reactions that operate within and between the various compartments. Without focusing specifically on pollution, it also discusses ways in which these systems respond to perturbations, either those that are natural or those that are caused by humans. Background material from subjects such as atmospheric science, limnology, and soil science is provided in order to establish a setting for a description of the relevant chemistry. Emphasis is on general principles that can be applied in a variety of circumstances. At the same time, these principles are illustrated with examples taken from around the world. Because of issues of the environment related to every society, care has been taken to relate the subject material to situations in urban and rural areas in both highly industrialized and low-income countries.
Author: Vineet Kumar
Publisher: CRC Press
ISBN: 1351021362
Category : Technology & Engineering
Languages : en
Pages : 370
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Book Description
The functionalization of nanomaterials provides them with some unique properties, making the same nanomaterial amenable for various applications by simply manipulating functional components. However, functionalized nanomaterials also face some challenges, along with some encouraging new applications in the future. This book provides a detailed account of applications of the functionalization of nanomaterials. This book can serve as a reference book for scientific investigators, including doctoral and post-doctoral scholars and undergraduate and graduate students, in context with the scope of applications of functionalized nanomaterials. It also highlights recent advances, challenges, and opportunities in the application of nanomaterials. This book will provide critical and comparative data for nanotechnologists. It may also be beneficial for multidisciplinary researchers, industry personnel, journalists, policy makers, and the common public to understand the scope of functionalized nanomaterials in detail and in depth. Features: This book covers various applications of functionalized nanomaterials. It discusses recent global research trends and future applications of functionalized nanomaterials. It highlights the need for more rigorous regulatory frameworks for the safe use of functionalized nanomaterials. It contains contributions from international experts and will be a valuable resource for researchers.
Author: Mario Pagliaro
Publisher: Royal Society of Chemistry
ISBN: 1847558984
Category : Science
Languages : en
Pages : 208
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Book Description
This clear and concise book is the first to address the hot topic of functional silica gels and their applications.
Author: Vineet Kumar
Publisher: CRC Press
ISBN: 1000367207
Category : Technology & Engineering
Languages : en
Pages : 603
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Book Description
Nanomaterials contain some unique properties due to their nanometric size and surface functionalization. Nanomaterial functionalization also affects their compatibility to biocompatibility and toxicity behaviors. environment and living organism. This makes functionalized nanomaterials a material with huge scope and few challenges. This book provides detailed information about the nanomaterial functionalization and their application. Recent advancements, challenges and opportunities in the preparation and applications of functionalized nanomaterials are also highlighted. This book can serve as a reference book for scientific investigators, doctoral and post-doctoral scholars; undergrad and grad. This book is very useful for multidisciplinary researchers, industry personnel’s, journalists, and policy makers. Features: Covers all aspects of Nanomaterial functionalization and its applications Describes and methods of functionalized nanomaterials synthesis for different applications Discusses the challenges, recent findings, and cutting-edge global research trends on functionalization of nanomaterials and its applications It discusses the regulatory frameworks for the safe use of functionalized nanomaterials. It contains contributions from international experts from multiple disciplines.
Author: R Ahvenainen
Publisher: Elsevier
ISBN: 1855737027
Category : Technology & Engineering
Languages : en
Pages : 609
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Book Description
Packaging continues to be one of the most important and innovative areas in food processing. Edited by a leading expert in the field, and with its distinguished international team of contributors, Novel food packaging techniques provides an authoritative and comprehensive review of the key trends.Part one discusses the range of active packaging techniques such as the use of oxygen and other scavengers, moisture regulation and antimicrobial packaging in food preservation. It also covers the use of intelligent systems such as time-temperature and freshness indicators to assess food quality. Part two reviews developments in modified atmosphere packaging (MAP) and its role in enhancing product safety and quality. Part three describes packaging applied in practice to particular products such as meat and fish. Part four covers other key issues such as packaging optimisation, the legislative context, sustainable packaging and consumer attitudes.Novel food packaging techniques is a standard reference for the food industry in optimising the use of packaging to improve product safety and quality. - Provides an authoritative and comprehensive review of the key trends of food packaging - Discusses the range of active packaging techniques such as the use of oxygen and other scavengers, moisture regulation and antimicrobial packaging in food preservation - Covers packaging optimisation, the legislative context, sustainable packaging and consumer attitudes
Author: Bruno Filipe Carmelino Cardoso Sarmento
Publisher: Elsevier
ISBN: 9780323508780
Category : Science
Languages : en
Pages : 0
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Book Description
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
Author: Gordon Tiddy
Publisher: Royal Society of Chemistry
ISBN: 1849733783
Category : Science
Languages : en
Pages : 283
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Book Description
NanoFormulation covers advances in research, development and applications of innovative formulation technologies where nanomaterials play an essential role.
