Functional Intracellular Compartmentation of Gluconeogenesis, Glycolysis, Ethanol Oxidation and Urea Synthesis as Studied in the Perfused Rat Liver PDF Download
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Author: John William Kramer
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: John William Kramer
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: John William Kramer
Publisher:
ISBN:
Category :
Languages : en
Pages : 220
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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 978
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Author: Xerox University Microfilms
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 968
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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 1276
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Author: University of California, Davis. Graduate Division
Publisher:
ISBN:
Category : Commencement ceremonies
Languages : en
Pages : 54
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 928
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Author: K. Jungermann
Publisher: Springer Science & Business Media
ISBN: 1468450417
Category : Medical
Languages : en
Pages : 495
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Book Description
The liver is an exceptionally complex and diverse organ that functions both as an exocrine and an endocrine gland. It secretes bile, which contains many con stituents in addition to bile salts, and it synthesizes and releases many substances in response to the body's demands, including prohormones, albumin, clotting factors, glucose, fatty acids, and various lipoproteins. It has a dual blood supply providing a rich mixture of nutrients and other absorbed substances via the portal vein and oxygen-rich blood via the hepatic artery. This functional heterogeneity is accompanied by cellular heterogeneity. The liver contains many cell types including hepatic parachymal cells, Kiipffer cells, Ito cells, and endothelial cells. The most abundant cell type, the parenchymal cells, are biochemically and structurally heterogeneous. The cells in the oxygen-rich areas of the portal triad appear more dependent on oxidative metabolism, whereas those around the central vein (pericentral, perivenous, or centrolobular areas) are more dependent upon an anaerobic mechanism. Throughout this volume the latter three terms are used synonymously by various authors to indicate the five to eight layers of cells radiating from the central vein. Structural and metabolic heterogeneity of hepatic parenchymal cells has been demonstrated by a variety of approaches, including histochemical, ultra structural, and ultramicrobiochemical studies. This microheterogeneity is linked to the physiological functions of the liver and its response to injurious substances.
Author: Xerox University Microfilms
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 1090
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Author: M. N. Berry
Publisher: Springer Science & Business Media
ISBN: 9780792361770
Category : Science
Languages : en
Pages : 630
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Book Description
It is thirty years since the technique of high-yield preparation of isolated hepatocytes, by collagenase perfusion of the liver, was published. The original method described by Berry and Friend has undergone many minor modifications by other workers, and the two-step procedure introduced by Seglen in 1976 has become the most frequent way to prepare hepatocyte suspensions. An important development introduced by Bissell in 1973 was the use of the cells as the first step in monolayer culture. The availability of the isolated hepatocyte preparation as cells in suspension or culture has undoubtedly facilitated research on the liver. This was emphasised in our book, published (with Dr. Greg Barritt) in 1990, which described in detail methods of preparation and the properties of the isolated hepatocytes. It also discussed the usefulness of the preparation for the study of intermediary and xenobiotic metabolism, calcium ion transport, and the growth and differentiation of hepatocytes in culture. The book also touched briefly on a range of specialised techniques, including peri fusion, subcellular fractionation, transplantation, cryopreservation and measurement of intracellular pH. Although standard procedures for the manipulation of hepatocytes have not changed a great deal in ten years, they have undoubtedly been refined. This applies particularly to hepatocyte culture techniques, cryopreservation, and even to preparation of hepatocyte suspensions, where it is now feasible to use purified enzymes. There is also much more emphasis on the use and study of human hepatocytes, particularly in the field of pharmacology and therapeutics.
