Author: Robert Anson Heinlein
Publisher:
ISBN: 9780739453452
Category : Science fiction, American
Languages : en
Pages : 709
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Book Description
Three young men do what we all wanted to - they build Rocket Ship Galileo and fly it to the moon. Of course it's not so simple: there are rivals and red tape to overcome, and a totally unexpected and possibly lethal -- surprise waiting for them when they get there. Matt Dodson has heroic dreams of joining Space Patrol, so he becomes a Space Cadet and embarks on the long and difficult training that will show if he can do the job. His mettle is tested to the utmost when, on his first training flight he finds himself in the midst of an interplanetary crisis. Jim Marlowe grew up on the Red Planet, and when he's sent off to boarding school at Syrtis Major, he insists on taking his Martian pet with him. He doesn't anticipate how much trouble friendly little Willis will get him into -- and how paradoxically lucky that will turn out to be. Bill Lerner can't wait to leave an overcrowded Earth and become a Farmer in the Sky on Ganymede. He thinks he's ready for hard work and hardship -- but he has no idea what it will mean when things go wrong and the nearest help is four hundred million miles away!
Author: George Nathaniel Curzon Marquis of Curzon
Publisher:
ISBN:
Category : Political Science
Languages : en
Pages : 74
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Book Description
Author:
Publisher:
ISBN:
Category : Military art and science
Languages : en
Pages : 908
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Book Description
Author: Frédéric Bornancin
Publisher: Frontiers Media SA
ISBN: 2889630560
Category :
Languages : en
Pages : 179
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Book Description
Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partner, called Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), was also implicated in the CARD-BCL10 pathway. Since then, the resulting “CBM” complex has been recognized as a key node in signaling cascades leading to NF-κB activation, particularly in immune cells. Mouse models of genetic deficiencies for each CBM component provided the first evidence for their critical role in cell signaling. More recently, studies of human lymphoid malignancies and novel genetic disorders have revealed important new insights. Both gain- and loss-of-function mutations were identified, establishing these CARMA/CARD proteins as key regulators of proliferation and differentiation of immune and non-immune cells, and linking them to human disease. According to the genetic defect involved, dysregulation of CARMA/CARD pathways can lead to a broad spectrum of immune disorders, including severe immune deficiencies, lymphoproliferative disorders, psoriasis and atopy. The aim of this Research Topic is to summarize and update our current understanding of CARMA/CARD protein biology, from initial discoveries to the most recent insights. It focuses on CARD9 and the CARMA proteins CARD10, CARD11 and CARD14, from genetic, signaling and disease perspectives. BCL10 and MALT1 are also reviewed in this context as critical nodes for CBM signal relay and regulation. This Research Topic also aims to delineate the next key questions in the field to guide future research efforts.
Author: James De Pui
Publisher:
ISBN:
Category : Bible
Languages : en
Pages : 316
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Book Description
Author: Paul E. Hoffman
Publisher: Indiana University Press
ISBN: 9780253108784
Category : History
Languages : en
Pages : 504
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Book Description
Florida has had many frontiers. Imagination, greed, missionary zeal, disease, war, and diplomacy have created its historical boundaries. Bodies of water, soil, flora and fauna, the patterns of Native American occupation, and ways of colonizing have defined Florida's frontiers. Paul E. Hoffman tells the story of those frontiers and how the land and the people shaped them during the three centuries from 1565 to 1860. For settlers to La Florida, the American Southeast ca. 1500, better natural and human resources were found on the piedmont and on the western side of Florida's central ridge, while the coasts and coastal plains proved far less inviting. But natural environment was only one important factor in the settlement of Florida. The Spaniards, the British, the Seminole and Miccosuki, the Spaniards once again, and finally Americans constructed their Florida frontiers in interaction with the Native Americans who were present, the vestiges of earlier frontiers, and international events. The near-completion of the range and township surveys by 1860 and of the deportation of most of the Seminole and Miccosuki mark the end of the Florida frontier, though frontier-like conditions persisted in many parts of the state into the early 20th century. For this major work of Florida history, Hoffman has drawn from a broad range of secondary works and from his intensive research in Spanish archival sources of the 16th and 17th centuries. Florida's Frontiers will be welcomed by students of history well beyond the Sunshine State.
Author: National Academy of Engineering
Publisher: National Academies Press
ISBN: 0309450365
Category : Technology & Engineering
Languages : en
Pages : 145
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Book Description
This volume presents papers on the topics covered at the National Academy of Engineering's 2016 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2016 symposium was held September 19-21 at the Arnold and Mabel Beckman Center in Irvine, California. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.
Author: A. D. Lee
Publisher: Cambridge University Press
ISBN: 9780521028257
Category : History
Languages : en
Pages : 240
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Book Description
This book deals with an important facet of late Roman history which has not received systematic treatment.
Author: Robert H. Jackson
Publisher: University of Oklahoma Press
ISBN: 0806159316
Category : History
Languages : en
Pages : 209
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Book Description
The Spanish crown wanted native peoples in its American territories to be evangelized and, to that end, facilitated the establishment of missions by various Catholic orders. Focusing on the Franciscan missions of the Sierra Gorda in Northern New Spain (Mexico) and the Jesuit missions of Chiquitos in what is now Bolivia, Frontiers of Evangelization takes a comparative approach to understanding the experiences of indigenous populations in missions on the frontiers of Spanish America. Marshaling a wealth of data from sacramental, military, and census records, Robert H. Jackson explores the many factors that influenced the stability of mission settlements, including the indigenous communities’ previous subsistence patterns and family structures, the evangelical techniques of the missionary orders, the social and political organization within the mission communities, and epidemiology in relation to population density and mobility. The two orders, Jackson’s research shows, organized and administered their missions very differently. The Franciscans took a heavy-handed approach and implemented disruptive social policies, while the Jesuits engaged in a comparatively “kinder and gentler” form of colonization. Yet the most critical factor to the missions’ success, Jackson finds, was the indigenous peoples’ existing demographic profile—in particular, their mobility. Nonsedentary populations, like the Pames and Jonaces of the Sierra Gorda, were more prone to demographic collapse once brought into the mission system, whereas sedentary groups, like the Guaraní of Chiquitos, experienced robust growth and greater resistance to disease and natural disaster. Drawing on more than three decades of scholarly work, this analysis of crucial archival material augments our understanding of the role of missions in colonization, and the fate of indigenous peoples in Spanish America.
Author:
Publisher:
ISBN:
Category : China
Languages : en
Pages : 556
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Book Description
