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Author: James H. Clark
Publisher: CRC Press
ISBN: 135107833X
Category : Science
Languages : en
Pages : 199
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Book Description
Describes methods for introducing fluorine and small fluorine-containing substituents into aromatic rings Considers traditional and modern synthetic methods, including industrial processes Focuses on the synthesis of selectively fluorinated aromatic molecules that represent an increasingly important class of intermediates Examines both historical development and future trends in this increasingly important area of chemistry
Author: James H. Clark
Publisher: CRC Press
ISBN: 135107833X
Category : Science
Languages : en
Pages : 199
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Book Description
Describes methods for introducing fluorine and small fluorine-containing substituents into aromatic rings Considers traditional and modern synthetic methods, including industrial processes Focuses on the synthesis of selectively fluorinated aromatic molecules that represent an increasingly important class of intermediates Examines both historical development and future trends in this increasingly important area of chemistry
Author: James H. Clark
Publisher: CRC Press
ISBN: 1351086782
Category : Science
Languages : en
Pages : 362
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Book Description
Academia and industry join forces in Aromatic Fluorination, as an expert from each domain contributes to this new text on fluorination of carbocyclic and heterocyclic rings. The book begins with a discussion of fluorine's unique combination of properties, including size, electronic effects, and hydrophobicity, as well as the historical development of its product applications. It explains methods for introducing fluorine into an aromatic ring, focusing on nucleophilic fluorine transfer reactions. The role of catalysts, solvents, and other variables are examined, and the scope and limitations of the methods are discussed. Of particular interest to those working in non-specialist laboratories, Aromatic Fluorination includes detailed descriptions of the new electrophilic routes to fluoroaromatics, in addition to traditional routes and alternative methods involving radical chemistry. Because one of the most important fluorine-containing substituent is CF3, the book explains routes to benzotrifluorides (ArCF3), including traditional industrial methods and modern alternatives employing C-1 halofluorocarbons and other fluoroaliphatics. An alternative to CF3 is CF3S, and several methods of synthesizing aromatic CF3S-containing molecules are described. Since the successful development and diverse applications of aromatic fluorine compounds have led to the search for new compounds and novel substituents, the incorporation of other substituents is also explored. Aromatic Fluorination concludes with discussion of the factors responsible for the successful development of pharmaceutical, agrochemical and liquid crystal applications and the potential for applications in high-performance polymers and other areas. This section also describes in detail important industrial aromatic fluorination processes and the relative merits of different process technologies and their costs.
Author: A. P. Kharitonov
Publisher: Nova Publishers
ISBN: 9781604562071
Category : Science
Languages : en
Pages : 110
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Book Description
"In this book fundamental features and industrial applications of the direct fluorination of polymers are reviewed. Direct fluorination of polymers (i.e. treatment of a polymer surface with gaseous fluorine and its mixtures) proceeds at room temperature spontaneously and can be considered as a surface modification process."--BOOK JACKET.
Author: Al Postigo
Publisher: Elsevier
ISBN: 9780128129586
Category : Science
Languages : en
Pages : 0
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Book Description
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.
Author: Alain Tressaud
Publisher: Elsevier
ISBN: 0080558119
Category : Medical
Languages : en
Pages : 821
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Book Description
Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics
Author: Al Postigo
Publisher: Elsevier
ISBN: 0128130393
Category : Science
Languages : en
Pages : 392
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Book Description
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. - Highlights the latest developments in the field in a concise volume - Provides details of key fluorinating reagents across diverse families of organic compounds - Explores the current applications and future potential of fluorine in drug development
Author: G. G. Furin
Publisher: Taylor & Francis US
ISBN: 9783718651573
Category : Science
Languages : en
Pages : 158
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Book Description
Author: Latimer R. Evans
Publisher:
ISBN:
Category : Antimony
Languages : en
Pages : 60
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Book Description
Author: Bruce Walter Hotten
Publisher:
ISBN:
Category : Cobalt
Languages : en
Pages : 102
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Book Description
Author: Robert Lucien Ritter
Publisher:
ISBN:
Category : Copper oxide
Languages : en
Pages : 270
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Book Description
