Fast Facts: Acute Lymphoblastic Leukemia PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Fast Facts: Acute Lymphoblastic Leukemia PDF full book. Access full book title Fast Facts: Acute Lymphoblastic Leukemia by B. Wrench. Download full books in PDF and EPUB format.
Author: B. Wrench
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318069787
Category : Medical
Languages : en
Pages : 108
Get Book Here
Book Description
Acute lymphoblastic leukemia (ALL) is the most diagnosed childhood cancer worldwide. Although rare in adults, this aggressive cancer also shows a second smaller incidence peak in later middle age. Modern genetic profiling techniques are providing a better understanding of the molecular biology of ALL, which, in turn, is leading to significant advances in diagnosis, prognostication and therapy selection. Ongoing refinement of risk-adapted frontline treatment protocols, use of novel targeted therapies and better supportive care are improving outcomes for patients with ALL. Fast Facts: Acute Lymphoblastic Leukemia covers the epidemiology, etiology, diagnosis and classification of ALL as well as the measurement of minimal residual disease to determine prognosis. It provides guidance on frontline therapies and the treatment of relapsed and refractory ALL, including the use of newer targeted agents and the role of allogeneic stem-cell transplantation. Looking to the future, it also considers the approaches and refinements that are in development for ALL.Table of Contents: Epidemiology, pathophysiology and etiology Diagnosis Prognostic factors Treatment Relapsed or refractory ALL Future directions
Author: B. Wrench
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318069787
Category : Medical
Languages : en
Pages : 108
Get Book Here
Book Description
Acute lymphoblastic leukemia (ALL) is the most diagnosed childhood cancer worldwide. Although rare in adults, this aggressive cancer also shows a second smaller incidence peak in later middle age. Modern genetic profiling techniques are providing a better understanding of the molecular biology of ALL, which, in turn, is leading to significant advances in diagnosis, prognostication and therapy selection. Ongoing refinement of risk-adapted frontline treatment protocols, use of novel targeted therapies and better supportive care are improving outcomes for patients with ALL. Fast Facts: Acute Lymphoblastic Leukemia covers the epidemiology, etiology, diagnosis and classification of ALL as well as the measurement of minimal residual disease to determine prognosis. It provides guidance on frontline therapies and the treatment of relapsed and refractory ALL, including the use of newer targeted agents and the role of allogeneic stem-cell transplantation. Looking to the future, it also considers the approaches and refinements that are in development for ALL.Table of Contents: Epidemiology, pathophysiology and etiology Diagnosis Prognostic factors Treatment Relapsed or refractory ALL Future directions
Author: J. Loke
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318069493
Category : Medical
Languages : en
Pages : 138
Get Book Here
Book Description
Leukemia is a hematologic malignancy arising from hematopoietic stem cells (HSCs) in the bone marrow. Starting with a detailed description of hematopoiesis and what goes wrong in leukemia, this concise guide covers all aspects of the four most common subtypes of the disease. Although the incidence and prevalence of leukemia are rising worldwide, survival rates are also increasing. However, both the effects of the disease and the adverse effects of treatment remain complex challenges. Yet, as our understanding of the molecular landscape increases, therapeutic options are becoming more personalized. This revised and updated second edition of 'Fast Facts: Leukemia' addresses the causes and risk factors for each subtype of leukemia, the initial and confirmatory diagnostic tests, and the latest treatment options. Designed as a comprehensive primer for physician assistants, nurse practitioners, primary care providers, oncology nurses, hematology/ oncology trainees and pharmacists, this resource will help the non-specialist and those in training to identify leukemia early and provide a thorough understanding of the pathology and genetic basis of the disease, treatment options, and effective approaches to emergency and supportive care. Table of Contents: • Understanding blood and its components • What is leukemia? • Epidemiology, etiology and risk factors • Diagnosis • Staging and general management • Supportive care • Emergencies in leukemia
Author: Ronald Hoffman
Publisher:
ISBN: 9780443066283
Category : Blood
Languages : en
Pages : 2821
Get Book Here
Book Description
Author: Ajay Vora
Publisher: Springer
ISBN: 3319397087
Category : Medical
Languages : en
Pages : 345
Get Book Here
Book Description
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Author: Ashkan Emadi, MD, PhD
Publisher: Springer Publishing Company
ISBN: 1617052779
Category : Medical
Languages : en
Pages : 377
Get Book Here
Book Description
Acute Leukemia: An Illustrated Guide to Diagnosis and Treatment provides a comprehensive and concise visual reference on acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) seen in children and adults. This book addresses all aspects of AML and ALL including their risk factors, cytogenetics and mutational characteristics, diagnoses, clinical management and prognoses which are imperative and challenging for medical students, residents, hematology and medical oncology fellows, and even community oncologists and hematologists. It presents complex information relying predominantly on pictorial depictions rather than traditional text in a visually instructive format. It replaces the wordiness of a traditional textbook with original and adapted illustrations, instructive schemata and diagrams, photomicrographs, tables, detailed figure legends, and practical, ‘bite-sized’ text. The result is a visually engaging book that is easy to read, review, and remember. Crafted by world experts in the field, this digestible volume provides you with the must-know information that you can utilize when encountering AML and ALL patients who require immediate attention. Whether you are an early-career practitioner looking for quick guidance to managing a deadly disease or you are a seasoned clinician looking for a quick review of treatment protocols, this engaging format provides a unique and ‘go-to’ resource. Key Features: Contains over 40 tables and over 220 illustrations, histologic photomicrographs, flow diagrams, graphs, and schemata with detailed figure legends Presents complex scientific aspects such as cytogenetics and molecular mutations in a visually digestible and easy-to-understand format Provides helpful and evidence-based treatment recommendations when providing induction therapy, consolidation therapy, and bone marrow transplantation Includes unique chapters on managing psychosexual issues accompanying AML and ALL treatment as well as on the FDA drug development and clinical trial design process Includes digital access to the e-book as well as an online Image Bank
Author: William Blum
Publisher: Karger Medical and Scientific Publishers
ISBN: 1910797596
Category : Medical
Languages : en
Pages : 90
Get Book Here
Book Description
This last year has seen the approval of the first targeted treatments for acute myeloid leukemia (AML) - following decades with no new developments and a poor prognosis for most patients with the disease. The new drugs reflect the remarkable progress that has been made in our understanding of the pathophysiology of AML and its underlying cytogenetic and molecular abnormalities - which differ not only between patients but also within a patient over time and with treatment. 'Fast Facts: Acute Myeloid Leukemia' provides a comprehensive yet concise foundation for understanding AML: from basic epidemiology, diagnosis, classification and the current 'standard' treatment, through to recent advances in our understanding of the cytogenetic and molecular underpinnings of the disease, such as the IDH2 mutation, and the future for tailored therapy. It will be useful to primary care providers, medical students, specialist nurses, junior doctors and allied healthcare professionals who want to develop a thorough grounding in our evolving understanding of AML and its treatment. Contents: • Epidemiology, pathophysiology and etiology • Diagnosis • Treatment • Supportive care • Prognosis and monitoring • Emerging treatments • Useful resources
Author: J. Loke
Publisher: Karger Medical and Scientific Publishers
ISBN: 331806825X
Category : Medical
Languages : en
Pages : 33
Get Book Here
Book Description
Conventional methods of detecting disease remission in cancers such as leukemia rely on microscopic analysis of tissue samples. Measurable (or minimal) residual disease (MRD) describes the presence of disease beyond the levels of sensitivity afforded by microscopy. Fast Facts: Measurable Residual Disease describes what is meant by MRD, the opportunities and challenges afforded by its identification and the advantages and disadvantages of the methods used for its detection. Specific examples are given to illustrate the implications of detecting MRD in different disease scenarios, with emphasis on acute myeloid and lymphoblastic leukemias. With the recognition and monitoring of MRD likely to play an increasingly important role in disease prognosis and subsequent treatment direction, this accessible resource is ideal for any healthcare professional wanting to know more about this exciting and fast-moving area. Table of Contents: • What is measurable residual disease? • How is MRD measured? • What is the significance of MRD?
Author: J. Loke
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318066338
Category : Medical
Languages : en
Pages : 140
Get Book Here
Book Description
Aunque la incidencia y prevalencia de leucemia está aumentando a nivel mundial, los avances en el diagnóstico y el tratamiento indican que las tasas de supervivencia también están aumentando. Comenzando con una descripción detallada de la hematopoyesis y lo que está mal en caso de la leucemia, esta guía concisa abarca todos los aspectos de los cuatro subtipos más frecuentes de la enfermedad: leucemia mieloide aguda (AML), leucemia linfoblástica aguda (ALL), leucemia mieloide crónica (CML) y leucemia linfocítica crónica (CLL). Este libro considera las causas y factores de riesgo para cada subtipo de leucemia, las pruebas diagnósticas iniciales y confirmatorias (incluyendo métodos de citogenética y genética molecular) y las opciones de tratamiento más recientes. Tanto los efectos de la enfermedad como los efectos adversos del tratamiento siguen representando un desafío complejo y se considera el abordaje multidisciplinario necesario para una atención de apoyo efectiva. Por último, se examinan las complicaciones urgentes que requieren atención de emergencia. Diseñado como una guía integral para enfermeras especializadas, médicos de atención primaria y residentes de hematología/oncología, este recurso ayudará a quienes no son especialistas a identificar la leucemia en etapas tempranas y proporciona una comprensión detallada de la patología y la base genética de la enfermedad, las opciones de tratamiento y los abordajes efectivos a la atención de urgencia y cuidados de apoyo.
Author: S. Potluri
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318068349
Category : Medical
Languages : en
Pages : 54
Get Book Here
Book Description
The tyrosine kinase inhibitor (TKI) imatinib was the first treatment to specifically target cancer cells, rather than the relatively indiscriminate effects of conventional chemotherapy on any rapidly dividing cells. This concept of targeted treatment in cancer is one of the important advances in modern medicine in the last 30 years. Indeed, treatment with TKIs has transformed chronic myeloid leukemia (CML) from a cancer with a poor prognosis to one in which many patients can expect a normal lifespan. Success with the TKIs has prompted the question of whether it is desirable – or feasible – for patients to remain on treatment for long periods. While the TKIs are targeted, they are associated with considerable toxicity, and long-term treatment has important economic implications for health services and patients. Thus, the concept of treatment-free remission (TFR) has emerged for patients in deep clinical remission. Clinical research over the last decade has focused on whether treatment can be stopped, how to best monitor patients while off treatment, and how to intervene before a clinical relapse. As this research progresses, the tantalizing prospect of a cure for some patients seems increasingly feasible. This new Fast Facts title outlines this trail-blazing approach to the long-term management of patients living with CML in remission. It explains the concepts of molecular and hematologic relapse, the highly sensitive technologies that allow disease monitoring, and how TFR is best managed in practice. It is a concise educational resource, ideal for any healthcare professional involved in the treatment of patients with CML who wants to understand TFR, particularly clinical nurse specialists and pharmacists who increasingly help clinicians to run CML clinics. Table of Contents: • The concept of treatment-free remission • Measurement of disease burden • Clinical practice • Future directions
Author: Richard J. Buka
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318067415
Category : Medical
Languages : en
Pages : 71
Get Book Here
Book Description
Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells are and how they were developed, discusses the results of clinical trials and the management of toxicities, and outlines future improvements and applications. It is ideal reading for any healthcare professional wanting to know more about this exciting therapeutic field. Table of Contents: • CAR T cells • Clinical application • Practical aspects • Future directions
