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Author: Hildegard T. Greinix
Publisher: Walter de Gruyter
ISBN: 3110276135
Category : Medical
Languages : en
Pages : 228
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Book Description
Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.
Author: Hildegard T. Greinix
Publisher: Walter de Gruyter
ISBN: 3110276135
Category : Medical
Languages : en
Pages : 228
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Book Description
Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.
Author: Francis P. Gasparro
Publisher: R. G. Landes
ISBN:
Category : Medical
Languages : en
Pages : 158
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Book Description
Author: Michelle Kenyon
Publisher: Springer
ISBN: 3319500260
Category : Medical
Languages : en
Pages : 318
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Book Description
This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
Author: Ontario Medical Advisory Secretariat
Publisher:
ISBN:
Category :
Languages : en
Pages : 76
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Book Description
Author: Nicolaus Kröger
Publisher:
ISBN: 9781013273674
Category : Medical
Languages : en
Pages : 688
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Book Description
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author: Georgia B. Vogelsang
Publisher: Cambridge University Press
ISBN: 1139478893
Category : Medical
Languages : en
Pages : 427
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Book Description
Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Author: Carrillo Javier
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Extracorporeal photopheresis (ECP) for acute and chronic graft versus host disease (GVHD): a retrospective study.J. Carrillo Checa, M. Lu00f3pez Parra, O. Lu00f3pez Villar, A. Avendau00f1o Pita, D. Rivera Delgado, A. Martu00edn Lu00f3pez, E. Pu00e9rez Lu00f3pez, M. Cabrero Calvo, L. Vu00e1zquez Lu00f3pez, F. Su00e1nchez Guijo M.V. Mateos, M.D. Caballero Barrigon, L. Lu00f3pez Corral.Complejo Asistencial Universitario de Salamanca-IBSAL, Hematology, Salamanca, SpainKEY WORDS: GVHD, Extracorporeal Photopheresis, alloSCT.CONTEXT: GVHD is the most common complication after alloSCT. Steroids are the first line but more than 40% of these patients will not response.OBJECTIVE: Evaluate efficacy and safety of ECP for refractory GVHD.DESIGN: retrospective study of 84 patients treated with ECP between january-2010-april-2018 in our centre.PATIENTS: 84 patients with steroid-refractory acute/chronic GVHD after alloSCT. Patients who didnu00b4t complete 8 procedures were not evaluable.INTERVENTIONS: an integrated system of continue flow, processing a standard volumen. Patients with aGVHD received 2 consecutive sessions/week during 12 weeks, then 2 sessions/fortnight until stop steroids. Protocol for cGHVD was 2 sessions/fortnight during 12 weeks and 2 sessions/month during 3 months until stop steroids.MAIN OUTCOMES MEASURES: ORR, OS and security.RESULTS: -aGVHD(n=35): median age of 48 (11-71) and 65.7% men. Organ involved was skin (91.4%), gut (71.4%) and liver (40%). 15 patients present grade II, 3 grade III and 17 grade IV. ORR was 78.1% (CR:53.1%). All of patients with grade II-III responded, but only 10 of 17 patients with grade IV GVHD. Best organ response was skin (ORR:87.1%). Grade IV had and adverse outcome (median OS not reached VS 3 months, p=0.016) and CR after ECP was associated with favourable outcome (median OS not reached VS 6 months, p=0.061). With a median follow-up after ECP of 5 months (0-51), 51,4% live.-cGVHD(n=49):, median age of 55 (9-69) and 54% men. 24 had severe cGVHD. Principal organs involved were skin and mucosas. ORR was 69%(CR:24.4%). Responses of moderate was superior (80%). Best organ responses were oral (ORR:84%) and skin (ORR:80%). After a median follow-up of 29 months (3-96), OS after ECP at 2 years was 78.3%.- Security: 8 CMV reactivation and 2 fungical infections ocurring during ECP. Steroids could stop in majority of the patients. 6 GVHD reactivacion were observed during ECP, the majority respond with intensification.CONCLUSIONS: ECP is an effective and safe salvage therapy for GVHD, especially in grade II-III aGVHD and moderate cGVHD. Best organ responses are skin in aGVHD and skin and mucosa in cGVHD.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 218
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Book Description
Graft-versus-host disease (GvHD) is a severe complication occurring after hematopoietic stem cell transplantation (HSCT). It is caused by alloreactive T cells contained in the graft, and associated with severe morbidity and mortality. Glucocorticoids (GC) are the gold standard for first-line treatment of GvHD but once patients become steroid-refractory, they need to be treated with second-line therapies such as extracorporeal photopheresis (ECP). ECP is an immunomodulatory therapy currently used in the clinic for treating patients suffering acute GvHD (aGvHD) or chronic GvHD (cGvHD). During...
Author: Syed A. Abutalib
Publisher:
ISBN: 9783319551326
Category : Cell transplantation
Languages : en
Pages :
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Book Description
In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications. Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.
Author: Misha Rosenbach
Publisher: Springer
ISBN: 3319184490
Category : Medical
Languages : en
Pages : 415
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Book Description
Inpatient Dermatology is a concise and portable resource that synthesizes the most essential material to help physicians with recognition, differential diagnosis, work-up, and treatment of dermatologic issues in the hospitalized patient. Complete with hundreds of clinical and pathologic images, this volume is both an inpatient dermatology atlas and a practical guide to day-one, initial work-up, and management plan for common and rare skin diseases that occur in the inpatient setting. Each chapter is a bulleted, easy-to-read reference that focuses on one specific inpatient dermatologic condition, with carefully curated clinical photographs and corresponding histopathologic images to aid readers in developing clinical-pathologic correlation for the dermatologic diseases encountered in the hospital. Before each subsection the editors share diagnostic pearls, explaining their approach to these challenging conditions. This book is structured to be useful to physicians, residents, and medical students. It spans dermatology, emergency medicine, internal medicine, infectious disease, and rheumatology. Inpatient Dermatology is the go-to guide for hospital-based skin diseases, making even the most complex inpatient dermatologic issues approachable and understandable for any clinician.
