Exposure based waiving and triggering of tests within REACH

Exposure based waiving and triggering of tests within REACH PDF Author:
Publisher: Nordic Council of Ministers
ISBN: 9289315431
Category :
Languages : en
Pages : 39

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Book Description

Exposure based waiving and triggering of tests within REACH

Exposure based waiving and triggering of tests within REACH PDF Author:
Publisher: Nordic Council of Ministers
ISBN: 9289315431
Category :
Languages : en
Pages : 39

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Book Description


Risk Assessment of Chemicals: An Introduction

Risk Assessment of Chemicals: An Introduction PDF Author: C.J. van Leeuwen
Publisher: Springer Science & Business Media
ISBN: 1402061013
Category : Science
Languages : en
Pages : 706

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Book Description
At last – a second edition of this hugely important text that reflects the progress and experience gained in the last decade and aims at providing background and training material for a new generation of risk assessors. The authors offer an introduction to risk assessment of chemicals as well as basic background information on sources, emissions, distribution and fate processes for the estimation of exposure of plant and animal species in the environment and humans exposed via the environment, consumer products, and at the workplace. The coverage describes the basic principles and methods of risk assessment within their legislative frameworks (EU, USA, Japan and Canada).

Regulatory Toxicology

Regulatory Toxicology PDF Author: Franz-Xaver Reichl
Publisher: Springer
ISBN: 9783642353734
Category : Medical
Languages : en
Pages : 0

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Book Description
This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.

Environmental Release of and Exposure to Iron Oxide and Silver Nanoparticles

Environmental Release of and Exposure to Iron Oxide and Silver Nanoparticles PDF Author: Henning Wigger
Publisher: Springer
ISBN: 3658167912
Category : Technology & Engineering
Languages : en
Pages : 269

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Book Description
In this thesis a prospective approach was developed to identify and to assess current as well as potentially upcoming product applications with focus on environmental releases and exposures of engineered nanomaterials. The developed product application scenarios were illustrated in case studies on iron oxide and silver nanoparticles. It was shown that despite of prevailing knowledge gaps, reasonable estimations for environmental releases and exposures can be made. This novel approach facilitates the identification of early indicators for precautionary risk management measures and among them benign by design concepts in technology and product development.

Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates

Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates PDF Author:
Publisher:
ISBN:
Category : Freshwater invertebrates
Languages : en
Pages : 150

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Book Description
Sediment contamination is a widespread environmental problem that can potentially pose a threat to a variety of aquatic ecosystems. The sediment test methods in this manual will be used by The United States Environmental Protection Agency (USEPA) to make decisions under a range of statutory authorities concerning such issues as: dredged material disposal, registration of pesticides and toxic substances, superfound site assessment, and assessment and cleanup of hazardous waste treatment, storage, and disposal facilities. The use of uniform sediment testing procedures by USEPA programs is expected to increase data accuracy and precision, facilitate test replication, increase the comparative value of test results, and ultimately, increase the efficiency of regulatory processes requiring sediment tests.

Threshold of Toxicological Concern (TTC)

Threshold of Toxicological Concern (TTC) PDF Author: Nordisk Ministerråd
Publisher: Nordic Council of Ministers
ISBN: 9289311967
Category : Technology & Engineering
Languages : en
Pages : 54

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Book Description


Computational Nanotoxicology

Computational Nanotoxicology PDF Author: Agnieszka Gajewicz
Publisher: CRC Press
ISBN: 1000681424
Category : Medical
Languages : en
Pages : 307

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Book Description
The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of engineered nanoparticles, computational methods originally developed for regular (i.e., classic) chemicals cannot always be applied explicitly in nanotoxicology. Thus, the main idea of this book is to discuss the current state of the art and future needs in the development of computational modeling techniques for nanotoxicology. The book focuses on methodology. Among various in silico techniques, special attention is given to (i) computational chemistry (quantum mechanics, semi-empirical methods, density functional theory, molecular mechanics, molecular dynamics); (ii) nanochemoinformatic methods (quantitative structure–activity relationship modeling, grouping, read-across); and (iii) nanobioinformatic methods (genomics, transcriptomics, proteomics, metabolomics).

Methods for Assessing the Toxicity of Sediment-associated Contaminants with Estuarine and Marine Amphipods

Methods for Assessing the Toxicity of Sediment-associated Contaminants with Estuarine and Marine Amphipods PDF Author:
Publisher:
ISBN:
Category : Amphipoda
Languages : en
Pages : 158

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Book Description


Toxicokinetics

Toxicokinetics PDF Author:
Publisher:
ISBN:
Category : Drugs
Languages : en
Pages : 24

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Book Description


Social Isolation and Loneliness in Older Adults

Social Isolation and Loneliness in Older Adults PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309671035
Category : Social Science
Languages : en
Pages : 317

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Book Description
Social isolation and loneliness are serious yet underappreciated public health risks that affect a significant portion of the older adult population. Approximately one-quarter of community-dwelling Americans aged 65 and older are considered to be socially isolated, and a significant proportion of adults in the United States report feeling lonely. People who are 50 years of age or older are more likely to experience many of the risk factors that can cause or exacerbate social isolation or loneliness, such as living alone, the loss of family or friends, chronic illness, and sensory impairments. Over a life course, social isolation and loneliness may be episodic or chronic, depending upon an individual's circumstances and perceptions. A substantial body of evidence demonstrates that social isolation presents a major risk for premature mortality, comparable to other risk factors such as high blood pressure, smoking, or obesity. As older adults are particularly high-volume and high-frequency users of the health care system, there is an opportunity for health care professionals to identify, prevent, and mitigate the adverse health impacts of social isolation and loneliness in older adults. Social Isolation and Loneliness in Older Adults summarizes the evidence base and explores how social isolation and loneliness affect health and quality of life in adults aged 50 and older, particularly among low income, underserved, and vulnerable populations. This report makes recommendations specifically for clinical settings of health care to identify those who suffer the resultant negative health impacts of social isolation and loneliness and target interventions to improve their social conditions. Social Isolation and Loneliness in Older Adults considers clinical tools and methodologies, better education and training for the health care workforce, and dissemination and implementation that will be important for translating research into practice, especially as the evidence base for effective interventions continues to flourish.