Experimental Observations in the Morita Baylis-Hillman Reaction in Methanol PDF Download
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Author: Robert Erik Plata
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Historically, research projects have originated from the literature group meetings and it was at one of those late night Wednesday meetings, nascent in my graduate career, that I presented a theoretical paper over the mechanism of the Morita Baylis-Hillman reaction. Something about it caught my attention and a project was born. The Morita Baylis-Hillman reaction had been heavily studied in the literature in recent years by both experimental and computational means. Some of these computational studies had even defined a complete theoretical mechanistic energy profile for these reactions. This dissertation describes a combination of experimental and theoretical mechanistic probes, including the observation of intermediates, the independent generation and partitioning of intermediates, thermodynamic and kinetic measurements for both the main reaction and interrelated side reactions, isotopic incorporation from solvent, and kinetic isotope effects, to fully define a more realistic picture of the free-energy profile for a Morita Baylis-Hillman reaction in methanol. Although the majority of this dissertation will be about the Morita Baylis-Hillman reaction in methanol, it could not have been fully accomplished without having to study the Morita Baylis-Hillman in DMSO and the Morita Baylis-Hillman utilizing acrylonitrile as well. All of these observations will be discussed. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/150977
Author: Robert Erik Plata
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Historically, research projects have originated from the literature group meetings and it was at one of those late night Wednesday meetings, nascent in my graduate career, that I presented a theoretical paper over the mechanism of the Morita Baylis-Hillman reaction. Something about it caught my attention and a project was born. The Morita Baylis-Hillman reaction had been heavily studied in the literature in recent years by both experimental and computational means. Some of these computational studies had even defined a complete theoretical mechanistic energy profile for these reactions. This dissertation describes a combination of experimental and theoretical mechanistic probes, including the observation of intermediates, the independent generation and partitioning of intermediates, thermodynamic and kinetic measurements for both the main reaction and interrelated side reactions, isotopic incorporation from solvent, and kinetic isotope effects, to fully define a more realistic picture of the free-energy profile for a Morita Baylis-Hillman reaction in methanol. Although the majority of this dissertation will be about the Morita Baylis-Hillman reaction in methanol, it could not have been fully accomplished without having to study the Morita Baylis-Hillman in DMSO and the Morita Baylis-Hillman utilizing acrylonitrile as well. All of these observations will be discussed. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/150977
Author: Edwin Vedejs
Publisher: John Wiley & Sons
ISBN: 3527675159
Category : Science
Languages : en
Pages : 1488
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Book Description
This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.
Author: Edwin Vedejs
Publisher: John Wiley & Sons
ISBN: 3527336184
Category : Science
Languages : en
Pages : 1476
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Book Description
This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.
Author: Min Shi
Publisher: Royal Society of Chemistry
ISBN: 1849731292
Category : Science
Languages : en
Pages : 575
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Book Description
Aimed at graduate students and experienced chemists, in both academic and industrial laboratories, this book covers the Morita-Baylis-Hillman-type reactions.
Author: A. C. Knipe
Publisher: John Wiley & Sons
ISBN: 1119957672
Category : Science
Languages : en
Pages : 656
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Book Description
Organic Reaction Mechanisms 2007, the 43rd annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2007. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.
Author: Ewa Broclawik
Publisher: Springer
ISBN: 3030117146
Category : Science
Languages : en
Pages : 540
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Book Description
This book focuses on the electronic properties of transition metals in coordination environments. These properties are responsible for the unique and intricate activity of transition metal sites in bio- and inorganic catalysis, but also pose challenges for both theoretical and experimental studies. Written by an international group of recognized experts, the book reviews recent advances in computational modeling and discusses their interplay using experiments. It covers a broad range of topics, including advanced computational methods for transition metal systems; spectroscopic, electrochemical and catalytic properties of transition metals in coordination environments; metalloenzymes and biomimetic compounds; and spin-related phenomena. As such, the book offers an invaluable resource for all researchers and postgraduate students interested in both fundamental and application-oriented research in the field of transition metal systems.
Author: B. Bosnich
Publisher: Springer
ISBN: 9789401087919
Category : Science
Languages : en
Pages : 172
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Book Description
The rate of advance in areas of science is seldom constant. Usually certain fields effloresce with activity because of the ~ealization that solutions are possible to long standing important problems. So it is now with asymmetric catalysis, a field which promises to change profoundly the strategic thinking of synthetic chemists. As this Report will show, reagents which can induce catalytic enantiocontrol of chemical transformations could represent the ultimate synthetic method. Nearly all synthetic strategies of complex molecules involve steps which require enantiocontrol and, in many cases, a specific catalytic transformation embodying enan tiocontrol has enormous advantages in terms of the rate and economy of the reaction. Because asymmetric catalysis is in a formative stage, workers with different backgrounds have joined the field. This Workshop had representatives with organometallic, organic, structural, kinetic, enzymatic, microbiological and industrial backgrounds. Each had his own perspective and this Report represents a consensus of this group of eleven people. The result is probably as compre hensive and balanced a view of the subject as is possible at present. It is hoped that those who have until now had but a glancing interest in asymmetric catalysis will find this Report a useful indication of its present state. We believe that asymmetric catalysis will have an increasing impact on the development of chemistry and will eventually dominate much of synthetic and industrial chemistry.
Author: Montserrat Diéguez
Publisher: John Wiley & Sons
ISBN: 3527804072
Category : Technology & Engineering
Languages : en
Pages : 431
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Book Description
An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Author: Carlos A. M. Afonso
Publisher: Royal Society of Chemistry
ISBN: 1849739633
Category : Science
Languages : en
Pages : 976
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Book Description
This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.
Author: Aravind Asthagiri
Publisher: Royal Society of Chemistry
ISBN: 1849734518
Category : Science
Languages : en
Pages : 277
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Book Description
This book presents a comprehensive review of the methods and approaches being adopted to push forward the boundaries of computational catalysis.
