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Author: Wendell F. Smith
Publisher: SIAM
ISBN: 9780898718393
Category : Science
Languages : en
Pages : 386
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Book Description
Many products, such as foods, personal-care products, beverages, and cleaning agents, are made by mixing ingredients together. This book describes a systematic methodology for formulating such products so that they perform according to one's goals, providing scientists and engineers with a fast track to the implementation of the methodology. Experimental Design for Formulation contains examples from a wide variety of fields and includes a discussion of how to design experiments for a mixture setting and how to fit and interpret models in a mixture setting. It also introduces process variables, the combining of mixture and nonmixture variables in a designed experiment, and the concept of collinearity and the possible problems that can result from its presence. Experimental Design for Formulation is a useful manual for the formulator and can also be used by a resident statistician to teach an in-house short course. Statistical proofs are largely absent, and the formulas that are presented are included to explain how the various software packages carry out the analysis. Many examples are given of output from statistical software packages, and the proper interpretation of computer output is emphasized. Other topics presented include a discussion of an effect in a mixture setting, the presentation of elementary optimization methods, and multiple-response optimization wherein one seeks to optimize more than one response.
Author: Wendell F. Smith
Publisher: SIAM
ISBN: 9780898718393
Category : Science
Languages : en
Pages : 386
Get Book Here
Book Description
Many products, such as foods, personal-care products, beverages, and cleaning agents, are made by mixing ingredients together. This book describes a systematic methodology for formulating such products so that they perform according to one's goals, providing scientists and engineers with a fast track to the implementation of the methodology. Experimental Design for Formulation contains examples from a wide variety of fields and includes a discussion of how to design experiments for a mixture setting and how to fit and interpret models in a mixture setting. It also introduces process variables, the combining of mixture and nonmixture variables in a designed experiment, and the concept of collinearity and the possible problems that can result from its presence. Experimental Design for Formulation is a useful manual for the formulator and can also be used by a resident statistician to teach an in-house short course. Statistical proofs are largely absent, and the formulas that are presented are included to explain how the various software packages carry out the analysis. Many examples are given of output from statistical software packages, and the proper interpretation of computer output is emphasized. Other topics presented include a discussion of an effect in a mixture setting, the presentation of elementary optimization methods, and multiple-response optimization wherein one seeks to optimize more than one response.
Author: Wendell F. Smith
Publisher: SIAM
ISBN: 0898715806
Category : Science
Languages : en
Pages : 372
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Book Description
Gender-Structured Population Modeling: Mathematical Methods, Numerics, and Simulations gives a unified presentation of and mathematical framework for modeling population growth by couple formation.
Author: Gareth A. Lewis
Publisher: CRC Press
ISBN: 0824746880
Category : Mathematics
Languages : en
Pages : 512
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Book Description
This useful reference describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process-including preformulation, formulation, process study and optimization, scale-up, and robust process and formulation development.Shows how to overcome pharmaceutical, technological, and economic constraint
Author: Maria Isabel Rodrigues
Publisher: CRC Press
ISBN: 1482299569
Category : Science
Languages : en
Pages : 324
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Book Description
Experimental Design and Process Optimization delves deep into the design of experiments (DOE). The book includes Central Composite Rotational Design (CCRD), fractional factorial, and Plackett and Burman designs as a means to solve challenges in research and development as well as a tool for the improvement of the processes already implemented. Appr
Author: Sarwar Beg
Publisher:
ISBN: 9789813343528
Category :
Languages : en
Pages : 0
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Book Description
This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel. .
Author: Reynir Eyjolfsson
Publisher: Academic Press
ISBN: 012802187X
Category : Medical
Languages : en
Pages : 68
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Book Description
Design and Manufacture of Pharmaceutical Tablets offers real world solutions and outcomes of formulation and processing challenges of pharmaceutical tablets. This book includes numerous practical examples related to actual formulations that have been validated and marketed and covers important data in the areas of stability, dissolution, bioavailibity and processing. It provides important background and theoretical information on design and manufacturing and includes a full section dedicated to design experimental methodology and statistics. In addition, this book offers a a general discussion of excipients used in proper tablet design along with practical examples related to excipients. Drug development scientists in industry and academia, as well as students in the pharmaceutical sciences will greatly benefit from the practical knowledge and case examples provided throughout this book. - Incorporates important mathematical models and computational applications - Includes unique content on central composite design and augmented simplex lattice - Provides background on important design principles with emphasis on quality-based design (QBD) of pharmaceutical dosage forms
Author: Gary W. Oehlert
Publisher: W. H. Freeman
ISBN: 9780716735106
Category : Mathematics
Languages : en
Pages : 600
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Book Description
Oehlert's text is suitable for either a service course for non-statistics graduate students or for statistics majors. Unlike most texts for the one-term grad/upper level course on experimental design, Oehlert's new book offers a superb balance of both analysis and design, presenting three practical themes to students: • when to use various designs • how to analyze the results • how to recognize various design options Also, unlike other older texts, the book is fully oriented toward the use of statistical software in analyzing experiments.
Author: Manju Rawat Singh
Publisher: Academic Press
ISBN: 0128199180
Category : Medical
Languages : en
Pages : 657
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Book Description
Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. - Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies - Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization - Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives
Author: Friedrich Pukelsheim
Publisher: SIAM
ISBN: 0898716047
Category : Mathematics
Languages : en
Pages : 527
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Book Description
Optimal Design of Experiments offers a rare blend of linear algebra, convex analysis, and statistics. The optimal design for statistical experiments is first formulated as a concave matrix optimization problem. Using tools from convex analysis, the problem is solved generally for a wide class of optimality criteria such as D-, A-, or E-optimality. The book then offers a complementary approach that calls for the study of the symmetry properties of the design problem, exploiting such notions as matrix majorization and the Kiefer matrix ordering. The results are illustrated with optimal designs for polynomial fit models, Bayes designs, balanced incomplete block designs, exchangeable designs on the cube, rotatable designs on the sphere, and many other examples.
Author: Valentim R. Alferes
Publisher: SAGE
ISBN: 1452202923
Category : Psychology
Languages : en
Pages : 209
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Book Description
This text provides a conceptual systematization and a practical tool for the randomization of between-subjects and within-subjects experimental designs.
