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Author: H. Bartsch
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 392
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Book Description
The use of exocyclic adducts as biomarkers offers a promising tool in studies of cancer etiology and prevention, particularly for human neoplasias in which the causative factors and mechanisms are still poorly understood. Presentations at an international conference, which resulted in this volume, comprise a comprehensive treatise on the current state of the art and scientific information on exocyclic DNA adducts. The volume includes sections on ultra sensitive detection methods, formation from exogenous and endogenous sources, DNA repair, physical chemical approaches to structural elucidation, and use as biomarkers and their role in mutagenesis and carcinogenesis.
Author: H. Bartsch
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 392
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Book Description
The use of exocyclic adducts as biomarkers offers a promising tool in studies of cancer etiology and prevention, particularly for human neoplasias in which the causative factors and mechanisms are still poorly understood. Presentations at an international conference, which resulted in this volume, comprise a comprehensive treatise on the current state of the art and scientific information on exocyclic DNA adducts. The volume includes sections on ultra sensitive detection methods, formation from exogenous and endogenous sources, DNA repair, physical chemical approaches to structural elucidation, and use as biomarkers and their role in mutagenesis and carcinogenesis.
Author: Beatrice Singer
Publisher:
ISBN:
Category : Language Arts & Disciplines
Languages : en
Pages : 504
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Book Description
The chemicals discussed here include possible or identified human carcinogens, chemotherapeutic agents, and a number of mutagenic substances for which human exposure is known to occur. More than 40 presentations cover occurrence, epidemiology, and carcinogenic affects; chemistry and formation of cyclic and other adducts; metabolism; biological effects; mechanistic approaches; and sensitive methods for detection of nucleic acid adducts. For oncologists, specialists in occupational health, and biochemists.
Author: Emerson Álvarez
Publisher: Nova Science Publishers
ISBN: 9781607414339
Category : DNA adducts
Languages : en
Pages : 0
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Book Description
Numerous physical and chemical stress factors, endogenous or exogenous, challenge living organisms. Metabolisation processes generate highly reactive intermediates which can covalently bind to DNA, resulting in bulky addition products called "adducts." DNA adduct formation appears to be a general response of plants to organic chemical exposure, whether in controlled conditions or in the field. In particular, common carcinogenic pollutants and pesticides promote the formation of DNA adducts in plants. The authors of this book examine the development of DNA adducts, as well as the ways in which they can be eliminated due to DNA repair pathways. In this book, the data from in vivo transgenic assays is also examined, which can help to clarify specific pre-mutagenic adducts, DNA repair functions and mutational events that may be involved in the mutagenicity of human carcinogens. Other chapters in this book identify and discuss novel anthracyclines capable of forming DNA adducts, the role of DNA adducts as early biomarkers in the screening and development of marine anticancer drugs, the genotoxicity, such as DNA adduct formation, of air pollutants and its assessment by in vivo mutagenesis and a discussion of oxidative DNA damage, which can play an important role in the carcinogenic processes of PAHs and aromatic amines, in addition to bulky-DNA adducts formation.
Author: H. Bartsch
Publisher:
ISBN: 9789283221500
Category : Medical
Languages : en
Pages : 392
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Book Description
The use of exocyclic adducts as biomarkers offers a promising tool in studies of cancer etiology and prevention, particularly for human neoplasias in which the causative factors and mechanisms are still poorly understood. Presentations at an international conference, which resulted in this volume, comprise a comprehensive treatise on the current state of the art and scientific information on exocyclic DNA adducts. The volume includes sections on ultra sensitive detection methods, formation from exogenous and endogenous sources, DNA repair, physical chemical approaches to structural elucidation, and use as biomarkers and their role in mutagenesis and carcinogenesis.
Author:
Publisher: Springer Science & Business Media
ISBN: 3642747752
Category : Medical
Languages : en
Pages : 617
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Book Description
I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Author: Christopher W. Lawrence
Publisher: Springer Science & Business Media
ISBN: 1468443828
Category : Medical
Languages : en
Pages : 433
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Book Description
Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author:
Publisher:
ISBN:
Category : Carcinogens
Languages : en
Pages : 440
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Book Description
Author: International Agency for Research on Cancer
Publisher: World Health Organization
ISBN:
Category : Law
Languages : en
Pages : 500
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Book Description
This is the first and only handbook to provide a comprehensive review of the critical intermediates in the first step of the process of carcinogenesis. This volume reviews current knowledge of DNA adducts formed by a wide range of classes of chemical compound, including the metabolism of chemicals, mechanisms of adduction, preparation and properties of standard compounds, adduct formation in vitro, measurements of adducts in humans, and biological significance. Additional chapters review our understanding of specific types of gene damage and mutagenecity and their reaction to cancer. This volume will provide invaluable, up-to-date facts for all researchers in mechanism of carcinogenesis, toxicology, and molecular epidemiology.
Author: Arthur P. Schaap
Publisher:
ISBN: 9780470150528
Category : Active oxygen
Languages : en
Pages : 0
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Book Description
