Existing chemicals: Evaluating the Use of QSAR for Estimating Biological Effects PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Existing chemicals: Evaluating the Use of QSAR for Estimating Biological Effects PDF full book. Access full book title Existing chemicals: Evaluating the Use of QSAR for Estimating Biological Effects by Ada Lagersted. Download full books in PDF and EPUB format.
Author: Ada Lagersted
Publisher: Nordic Council of Ministers
ISBN: 9788773033616
Category : Hydrazines
Languages : en
Pages : 166
Get Book
Book Description
Author: Ada Lagersted
Publisher: Nordic Council of Ministers
ISBN: 9788773033616
Category : Hydrazines
Languages : en
Pages : 166
Get Book
Book Description
Author: Ada Lagersted
Publisher:
ISBN: 9789179961831
Category : Hydrazines
Languages : en
Pages : 159
Get Book
Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309310164
Category : Science
Languages : en
Pages : 280
Get Book
Book Description
Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.
Author: Mona Møller
Publisher: Nordic Council of Ministers
ISBN: 9788773033593
Category :
Languages : en
Pages : 68
Get Book
Book Description
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1628
Get Book
Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Kunal Roy
Publisher: Academic Press
ISBN: 0128016337
Category : Medical
Languages : en
Pages : 484
Get Book
Book Description
Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment describes the historical evolution of quantitative structure-activity relationship (QSAR) approaches and their fundamental principles. This book includes clear, introductory coverage of the statistical methods applied in QSAR and new QSAR techniques, such as HQSAR and G-QSAR. Containing real-world examples that illustrate important methodologies, this book identifies QSAR as a valuable tool for many different applications, including drug discovery, predictive toxicology and risk assessment. Written in a straightforward and engaging manner, this is the ideal resource for all those looking for general and practical knowledge of QSAR methods. Includes numerous practical examples related to QSAR methods and applications Follows the Organization for Economic Co-operation and Development principles for QSAR model development Discusses related techniques such as structure-based design and the combination of structure- and ligand-based design tools
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 1439830096
Category : Medical
Languages : en
Pages : 312
Get Book
Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1328
Get Book
Book Description
Author:
Publisher:
ISBN:
Category : Health risk assessment
Languages : en
Pages : 94
Get Book
Book Description
Author:
Publisher:
ISBN:
Category : Ecological risk assessment
Languages : en
Pages : 232
Get Book
Book Description
