Evaluation of the Cell-mediated Immune Response to Bovine Respiratory Syncytial Virus Infection in Cattle PDF Download
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Author: Emery Waine Field
Publisher:
ISBN:
Category : Cattle
Languages : en
Pages : 146
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Book Description
Author: Emery Waine Field
Publisher:
ISBN:
Category : Cattle
Languages : en
Pages : 146
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Book Description
Author: Amelia Raye Woolums
Publisher:
ISBN:
Category :
Languages : en
Pages : 292
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Author: Robert Rankin
Publisher:
ISBN:
Category : Cattle
Languages : en
Pages :
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Author: Robert Rankin
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Matthew Robert Sandbulte
Publisher:
ISBN:
Category :
Languages : en
Pages : 344
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Book Description
Bovine respiratory syncytial virus (BRSV) causes mild to severe respiratory disease in calves. The literature review section of this dissertation summarizes current knowledge of BRSV, immunity to BRSV, bovine T cell biology, and methods for analyzing cell-mediated immunity (CMI) in domestic animals. Previous work indicates that CMI responses to BRSV are critical to protective immunity. Studies described here were designed to characterize BRSV-specific responses by the different T cell subsets, particularly following vaccination. In vitro assays for BRSV-specific T cell activation were performed in parallel with conventional serum virus neutralizing antibody assays. In one study, BRSV-responsive CD4, CD8+, and [gamma][delta] T cells were identified in calves lacking detectable antibody to the virus. It was demonstrated that these individuals had immunological memory for BRSV, as they mounted anamnestic-like antibody responses to a vaccine. The practical implications are that seronegative calves are not necessarily immunologically naïve and seroconversion may not be a necessary correlate for protective immunity after vaccinating calves that have maternal antibody. In two other studies, T cell priming was monitored following immunization with commercial modified-live virus (MLV) or inactivated, adjuvanted BRSV vaccines. In the first of these experiments, calves were initially seronegative and T cell negative to BRSV. The inactivated vaccine induced higher, more sustained CD4+ and [gamma][delta] T cell responses than MLV. Inactivated vaccine also induced CD8+ T cell responses as high as those induced by MLV. In the second of these experiments, comparable vaccines from other commercial sources were administered to calves with pre-existing antibody (presumably maternal), but no detectable T cell memory. Again, greater antigen-specific T cell responses were observed in calves receiving inactivated virus with adjuvant than those receiving MLV. These results seem to support the use of inactivated BRSV vaccines, which does not conform to usual expectations of live and inactivated vaccines. Another study examined interactions between bovine T cells and modified vaccinia virus Ankara (MVA), a potential vector for BRSV gene expression in vaccines or in vitro studies. [gamma][delta] T cells from normal cattle tended to respond to MVA in vitro, in a manner consistent with an innate response or antigen cross-reactivity.
Author: Liana Brentano
Publisher:
ISBN:
Category : Cattle
Languages : en
Pages : 340
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Author: Kim A. Brogden
Publisher:
ISBN:
Category : Bacteria
Languages : en
Pages : 460
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Book Description
Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.
Author: Thomas J. Divers
Publisher: Elsevier Health Sciences
ISBN: 1437710832
Category : Medical
Languages : en
Pages : 704
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Book Description
REBHUN'S DISEASES OF DAIRY CATTLE, 2nd Edition is your all-in-one guide to bovine disease management. With thorough, up-to-date coverage of differential diagnosis methods, surgical and therapeutic treatment options, and prevention strategies, it provides vital information for battling bovine diseases in both dairy and non-dairy cattle. The book is organized by body system for quick, convenient reference, and this new edition meets the growing need for management of both diseases of individual cows and problems affecting whole herds. Individual case presentations provide a valuable tool for differential diagnosis. Practical overviews for procedures such as blood transfusion, abdominal paracentesis, and ECG give you reliable support for some of the most common procedures in bovine care. Body systems organization makes diagnosis easier and more effective by isolating system-specific diseases and conditions. Full-color design and over 200 new photographs depict disease processes in realistic clarity and ensure the most accurate diagnosis and treatment. Emphasis on herd health addresses the dairy industry's increased concern over population medicine. Expanded coverage of lameness highlights key problem areas in bovine feet. Revised drug usage recommendations and legal considerations present the most current information in these critical areas to help you prevent dangerous or costly errors. Additional public health/safety considerations identify diseases that pose a substantial public threat and detail special measures for related care of dairy cattle. New, innovative DVD features real-time videos of neurologic case studies, ultrasound and endoscopy procedures, and imaging techniques that familiarize you with the latest technological equipment and protocols. Features coverage of the latest treatment innovations including antibiotic residue testing, care of individual metabolic disease, troubleshooting, and much more.
Author: A. L. Notkins
Publisher: Springer Science & Business Media
ISBN: 1461252504
Category : Science
Languages : en
Pages : 418
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Book Description
The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.
Author:
Publisher: Elsevier
ISBN: 0080526837
Category : Science
Languages : en
Pages : 875
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Book Description
This volume of Advances in Veterinary Medicine, derived in part from the First Veterinary Vaccines and Diagnostic Conferences, deals with vaccines, an especially active area of veterinary research and controversy.
