Enzymatic Basis of Detoxication Volume 2 PDF Download
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Author: William B. Jakoby
Publisher: Elsevier
ISBN: 0323138209
Category : Science
Languages : en
Pages : 384
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Book Description
Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.
Author: William B. Jakoby
Publisher: Elsevier
ISBN: 0323138209
Category : Science
Languages : en
Pages : 384
Get Book Here
Book Description
Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.
Author: William B. Jakoby
Publisher: Elsevier
ISBN: 0323137989
Category : Science
Languages : en
Pages : 432
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Book Description
Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.
Author: Ian R. Rowland
Publisher: CRC Press
ISBN: 9780849388125
Category : Medical
Languages : en
Pages : 572
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Book Description
Nutrition, Toxicity, and Cancer provides practical guidance on methodology for formulating diets and designing nutritional studies in animals and humans, in addition to valuable information on how nutrition influences specific biological processes such as biotransformation of foreign and endogenously produced compounds. The book also presents sample diets and advice on the layout of metabolic suites. Other topics discussed include the complex interactions between nutrition and carcinogenic processes, teratogenesis and mutagenesis. Toxicologists, cancer researchers, nutritionists, and biochemists should consider Nutrition, Toxicity, and Cancer to be an invaluable reference resource that provides up-to-date reviews on the effect of diet on mammalian and microbial metabolic processes in the body.
Author: Emel Arinç
Publisher: Springer Science & Business Media
ISBN: 1461548551
Category : Science
Languages : en
Pages : 297
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Book Description
Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997
Author: James J. Kocsis
Publisher: Springer Science & Business Media
ISBN: 1468451340
Category : Science
Languages : en
Pages : 1028
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Book Description
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Author: Mendel Friedman
Publisher: CRC Press
ISBN: 1351086340
Category : Medical
Languages : en
Pages : 392
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Book Description
Containing 45 papers written by outstanding international authors from 14 countries, this three-volume compendium brings together the elements needed to understand the factors which influence the utilization of amino acids. The wide-ranging topics include descriptions of metabolic pathways and mechanisms of the biological utilization of amino acids, as well as factors that influence amino acid bioavailability in enteral and parenteral nutrition. The use of amino acids to improve the quality and safety of the diet is presented. Also discussed are amino acid precursors of biogenic amines and the role of amino acids in atherosclerosis, cancer, and immunity. Scientists from many disciplines will benefit from this broad overview.
Author: Cohen
Publisher: CRC Press
ISBN: 1000714543
Category : Medical
Languages : en
Pages : 243
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Book Description
This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
Author: Ronald R. Scheline
Publisher: CRC Press
ISBN: 1351362933
Category : Nature
Languages : en
Pages : 868
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Book Description
Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.
Author: Robin S. Goldstein
Publisher: Elsevier
ISBN: 1483269701
Category : Medical
Languages : en
Pages : 503
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Book Description
Toxic Interactions is a collection of papers that discusses the basic principles behind the mechanism of toxicological interactions. This book deals with interacting chemicals and their effects on certain exposed organs or molecules. Concerning discussion of the principles, contributed papers explain the role of xenobiotic biotransformation processes in inactivating reactive intermediates of toxicants. Other authors discuss the effects of endogenous molecules and the consequences of chemically induced depletion of protective agents, as well as the pharmacokinetic principles that affect chemical interactions. Several authors also review experiments on the types of chemicals that produce or increase the degree of toxicity. The text reviews the results of liver and kidney injuries from exposure to two or more chemicals, while other papers focus on lung and heart toxicity. For example, direct mechanism of cardio toxicity includes toxicity due to an increase in plasma concentrations of the compound, or as in latent cardiac toxicity that is a product of another action on another system of organs. Professors in pharmacology, practitioners of general medicine, specialists or researchers dealing with microchemistry, toxicology or drug therapy will find this reference valuable.
Author:
Publisher: Academic Press
ISBN: 0080925456
Category : Science
Languages : en
Pages : 506
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Book Description
This volume presents the latest research on herbivores, aquatic and terrestrial mammals and insects. The Second Edition, written almost entirely by new authors, effectively complements the initial work. It includes advances in molecular biology and microbiology, ecology, and evolutionary theory that have been achieved since the first edition was published in 1979. The book also incorporates relatively new methodologies in the area of molecular biology, like protein purification and gene cloning. Volume II, Ecological and Evolutionary Processes, also opens up entirely new subjects: The discussions of interactions have expanded to include phenomena at higher trophic levels, such as predation and microbial processing and other environmental influences. Both this and Volume I, The Chemical Participants, will be of interest to chemists, biochemists, plant and insect ecologists, evolutionary biologists, physiologists, entomologists, and agroecologists interested in both crop and animal science. - Presents coevolution of herbivores and host plants - Examines resource availability and its effects on secondary metabolism and herbivores - Studies physiology and biochemistry of adaptation to hosts - Includes tri-trophic interactions involving predators and microbes
