Enhancing Nutraceuticals Bioavailability by Nanoemulsion-based Delivery and Excipient Systems PDF Download
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Author: Ruojie Zhang
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
There are numerous kinds of hydrophobic nutrients, nutraceuticals, and vitamins present in foods that can be consumed as part of whole foods, in an isolated form, or as part of processed foods. The oral bioavailability (BA) of many of these hydrophobic bioactives is relatively poor because of their limited bioaccessibility, low absorption, and/or transformation within the gastrointestinal tract (GIT). As a result, their potential health benefits may not be fully realized. The bioavailability of hydrophobic bioactives can be enhanced by designing food matrices that breakdown within the GIT to form compositions and structures capable of controlling the bioaccessibility, absorption, and transformation. Oil-in-water emulsions are particularly suitable for this purpose because their compositions, structures, and properties can easily be controlled. Nanoemulsions can be used to form bioactive delivery systems or excipient systems. The bioavailability of isolated bioactives can be improved by incorporating them in nanoemulsion-based delivery systems, while the bioavailability of bioactives in whole foods can be improved by ingesting them with nanoemulsion-based excipient systems. In this research, the biological fate of nanoemulsions with various compositions and structures were studied by utilizing the simulated gastrointestinal tract. In addition, the nanoemulsion-based delivery systems were established for enhancing the carotenoids bioaccessibility and curcumin accumulation in C. elegans. Furthermore, the nanoemulsion-based excipient systems were studied to enhancing the bioaccessibility of model vegetable, carrot, by optimizing their composition and structure. However, a potential drawback of the excipient emulsion is that co-ingestion of them with fruits or vegetables could increase pesticide bioaccessibility. Our research indicated that the food matrix could significantly impact the bioavailability of nutraceuticals and pesticides, it may further impact other ingested materials, such as nanoparticles. However, there are currently no standardized food models can be used. Therefore, a standardized food model(SFM) was establised based on the average composition of the US diet. The properties of the SFM and its impact on the bioacessibility of nutraceuticals and pesticides and the cycotoxicity of nanopartlces were studied. This information should be useful to facilitate the comparison of results obtained on food matrix effects from different laboratories.
Author: Ruojie Zhang
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
There are numerous kinds of hydrophobic nutrients, nutraceuticals, and vitamins present in foods that can be consumed as part of whole foods, in an isolated form, or as part of processed foods. The oral bioavailability (BA) of many of these hydrophobic bioactives is relatively poor because of their limited bioaccessibility, low absorption, and/or transformation within the gastrointestinal tract (GIT). As a result, their potential health benefits may not be fully realized. The bioavailability of hydrophobic bioactives can be enhanced by designing food matrices that breakdown within the GIT to form compositions and structures capable of controlling the bioaccessibility, absorption, and transformation. Oil-in-water emulsions are particularly suitable for this purpose because their compositions, structures, and properties can easily be controlled. Nanoemulsions can be used to form bioactive delivery systems or excipient systems. The bioavailability of isolated bioactives can be improved by incorporating them in nanoemulsion-based delivery systems, while the bioavailability of bioactives in whole foods can be improved by ingesting them with nanoemulsion-based excipient systems. In this research, the biological fate of nanoemulsions with various compositions and structures were studied by utilizing the simulated gastrointestinal tract. In addition, the nanoemulsion-based delivery systems were established for enhancing the carotenoids bioaccessibility and curcumin accumulation in C. elegans. Furthermore, the nanoemulsion-based excipient systems were studied to enhancing the bioaccessibility of model vegetable, carrot, by optimizing their composition and structure. However, a potential drawback of the excipient emulsion is that co-ingestion of them with fruits or vegetables could increase pesticide bioaccessibility. Our research indicated that the food matrix could significantly impact the bioavailability of nutraceuticals and pesticides, it may further impact other ingested materials, such as nanoparticles. However, there are currently no standardized food models can be used. Therefore, a standardized food model(SFM) was establised based on the average composition of the US diet. The properties of the SFM and its impact on the bioacessibility of nutraceuticals and pesticides and the cycotoxicity of nanopartlces were studied. This information should be useful to facilitate the comparison of results obtained on food matrix effects from different laboratories.
Author: Ming Miao
Publisher: Royal Society of Chemistry
ISBN: 183916557X
Category : Technology & Engineering
Languages : en
Pages : 464
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Book Description
There is growing interest in the food, supplements, cosmetics, and pharmaceutical industries in improving the healthiness of their products by incorporating lipophilic bioactive substances like oil-soluble vitamins (A, D and E), omega-3 fatty acids, and nutraceuticals (carotenoids, curcuminoids and flavonoids). However, there are many challenges that need to be overcome due to their poor water-solubility, chemical stability, and bioavailability. For this reason, there is interest in the development of effective encapsulation technologies to increase the efficacy of lipophilic bioactives. This book reviews the encapsulation systems currently available for delivering lipophilic bioactives, including their preparation, functionality, and application range, including nanoemulsions, emulsions, Pickering emulsions, HIPEs, microgels, organogels and liposomes. Chapters 1-2 review the biological activity of delivery systems and lipophilic bioactives. Chapters 3-5 describe the materials and preparation methods used to assemble delivery systems. Chapters 6-17 focus on the formation and application of different kinds of delivery systems. Chapter 18 discusses future trends in the development of bioactive delivery systems. Edited and authored by world renowned scholars, the book provides a state-of-the-art overview of the design, fabrication, and utilization of delivery systems for bioactives that will be useful for academic, government, and industrial scientists in fields such as pharmaceuticals, cosmetics, agriculture, chemical engineering, nutrition, and foods.
Author: Pankaj V. Dangre
Publisher: CRC Press
ISBN: 1000409910
Category : Medical
Languages : en
Pages : 432
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Book Description
This book highlights recent innovative work in nutraceutical delivery systems, focusing on strategies and approaches for delivering maximum health benefits from foods. It presents recent research-oriented work from diverse global perspectives on isolation techniques for nutraceutical components, phytosomes, liposomes, solid dispersions, micelles, self-emulsifying drug delivery systems, microemulsions, solid lipid nanoparticles, polyelectrolyte complexes, oral delivery, polymeric nanoparticles, and more. The book begins with an overview of recent facts and diverse perspectives on the use of nutraceuticals in medicine and proceeds to discuss recent techniques in isolation of nutraceuticals from plants and in solubility enhancement. It looks at innovations and advances in nanoparticles-based nutraceutical delivery, such as in solid lipid nanoparticles (SLNs), fabrication methods of therapeutic nanoparticles, and polymeric nanoparticles-based nutraceutical delivery system. It also discusses vesicular delivery systems and biphasic systems for nutraceutical applications. The book also looks at the challenges in oral delivery and the latest taste-masking techniques.
Author: Seid Mahdi Jafari
Publisher: Academic Press
ISBN: 0128118393
Category : Technology & Engineering
Languages : en
Pages : 665
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Book Description
Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. Summarizes general aspects of food nanoemulsions and their formulation Provides detailed information on the production, application, and characterization of food nanoemulsion Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations Explains preparation of nanoemulsions by both low- and high-energy methods
Author: Shampa Sen
Publisher: CRC Press
ISBN: 1498721893
Category : Technology & Engineering
Languages : en
Pages : 488
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Book Description
Shows how nanotechnology can be used to develop better functional foods and nutraceuticals. Provides detailed knowledge of current development in nutraceuticals. Discusses marketing and consumer acceptance of nanomaterials. Reviews current governmental regulations.
Author: Alexandru Grumezescu
Publisher: Academic Press
ISBN: 012804375X
Category : Science
Languages : en
Pages : 852
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Book Description
Nutrient Delivery: Nanotechnology in the Agri-Food Industry, Volume Five, discusses the fabrication, merits, demerits, applications, and bioavailability enhancement mechanisms of various nanodelivery systems. Recent developments in various nanodelivery systems are also highlighted. Volume 5 contains twenty chapters, prepared by outstanding international researchers from Argentina, Brazil, Canada, China, Croatia, India, Iran, Ireland, México, Pakistan, Portugal, Serbia, Sri Lanka, and the United States. In recent years, the delivery of micronutrients at nanoscale has been widely studied as these systems have the potential to improve bioavailability, enable controlled release and enhance stability of food bioactives to a greater extent. The nanodelivery systems typically consist of the food bioactive compound encapsulated and stabilized in food grade ingredients such as lipids, proteins or polysaccharides with diameters ranging from 10 nm to 1000 nm. Among these, the lipid based delivery systems such as nanoemulsions, solid lipid nanoparticles, nanoliposomes and micelles are widely studied for the delivery of lipophilic bioactive compounds. These delivery vehicles improve the solubility, permeability, stability and bioavailability of the lipophilic compounds thereby enhancing their potential for oral delivery and functional food development. On the other hand, the hydrophilic bioactives are delivered through protein, polysaccharide or biopolymer based colloidal nanosystems such as hydrogels, nanogels and polymer nanoparticles. The major concern other than solubility is the intestinal permeability of the micronutrients. For instance, the delivery system for compounds with poor intestinal permeability and low solubility need to be carefully designed using suitable lipids and surfactants. Offers updated material for undergraduate and postgraduate students in food science, biotechnology, and related engineering fields Provides a valuable resource of recent scientific progress, along with most known applications of nanomaterials in the food industry for researchers, engineers, and academics Includes novel opportunities and ideas for developing or improving technologies in the food industry
Author: David J. Hauss
Publisher: CRC Press
ISBN: 1420017268
Category : Medical
Languages : en
Pages : 370
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Book Description
Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem
Author: Bhupinder Singh
Publisher: CRC Press
ISBN: 1351138936
Category : Medical
Languages : en
Pages : 306
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Book Description
This book will be a comprehensive account of the various facets of nutraceuticals domain. The peruser of this book will find details on various nanotech approaches to nutraceuticals, prebiotics and probiotics, along with their specific applications.
Author: Alexandru Grumezescu
Publisher: Academic Press
ISBN: 0128043768
Category : Health & Fitness
Languages : en
Pages : 894
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Book Description
Nutraceuticals, the fourth volume in the Nanotechnology in the Agri-Food Industry series, is an invaluable resource for anyone in the food industry who needs the most current information about scientific advances in this field. Nutraceuticals are gaining significant attention because of their apparent safety, as well as their nutritional and therapeutic uses. Scientific indications have reinforced dietary interposition as an effective implement for a healthy lifestyle. Bioactive components have been shown to exhibit antioxidant, anti-inflammatory, antimicrobial, hypocholesterolemic, hypoglycemic, anti-mutagenic, and anti-carcinogenic roles in the living system. Research professionals, professors, and students will all find this book useful. Includes the most up-to-date research on nanotechniques and the applications most useful in the food industry Presents various natural and synthetic polymer-based nanoparticulate systems and their conjugates to the food industry including proteins, lipids, carbohydrates, and other biopolymers for applications Provides uses of nanoparticle uptake in ingredients as well as the potential side effects of nanoparticle carriers Covers potential benefits and methods of risk assessment for food safety
Author: Mingfei Yao
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The oral bioavailability of lipophilic bioactive molecules can be greatly increased by encapsulating them within engineered lipid nanoparticles, such as micelles, microemulsions and nanoemulsions. After ingestion these engineered lipid nanoparticles are disassembled in the gastrointestinal tract (GIT), and then reassembled into biological lipid nanoparticles (mixed micelles) in the small intestine. These mixed micelles solubilize and transport lipophilic bioactive components to the epithelium cells. The mixed micelles themselves are then disassembled and reassembled into yet another form of biological lipid nanoparticle (chylomicrons, CMs) within the enterocyte cells. The CMs carry the bioactive components into the systemic (blood) circulation via the lymphatic system, thereby avoiding metabolism in the small intestine and liver. Polymethoxyflavones (PMFs) are bioactive flavonoids found in citrus fruits that have been shown to have potential health promoting properties. However, their application as nutraceuticals in functional foods and beverages is currently limited due to their low water solubility and high melting point. The oral bioavailability of lipophilic compounds can be enhanced by promoting their intestinal lymphatic transport through co-administration with digestible lipids. First, we investigated the effects of chylomicron-mediated intestinal lymphatic transport on the bioavailability of 5-hydroxy-6, 7, 8, 3', 4'-pentamethoxylflavone (5-DN), one of representative PMFs in Caco-2 cells. Our results demonstrated that oleic acid and bile acid promoted secretion of CMs in Caco-2 cells, with mean diameter ranged from 70 to 150 nm. The intracellular level of 5-DN increased 3-fold by co-incubation with the mixed micelle solution. Moreover, the basolateral level of 5-DN increased 3-fold due to enhanced chylomicron-mediated transport. Based on the above results, we then evaluate the influence of different fatty acid types on the properties of mixed micelles, cellular lipid droplets and CMs, and on the uptake of the highly lipophilic nutraceutical 5-DN. There were distinct differences in the structural properties of CMs formed depending on fatty acid unsaturation. Oleic acid (C18:1) was most effective at enhancing transport of 5-DN and led to the formation of the largest CMs. Linoleic acid (C18:2) and linolenic acid (C18:3) also promoted 5-DN incorporation into CMs, but they were less efficient than oleic acid. The metabolism of 5-DN within the epithelium cells was greatly reduced when they were incorporated into CMs, presumably because they were isolated from metabolic enzymes in the cytoplasm. These results have important implications for the design of lipid nanoparticle-based delivery systems for lipophilic drugs and nutraceuticals by targeting them to the lymphatic circulation. Fatherly, we studied the effects of triglycerides-based nanoemulsion delivery systems with different fatty acid chain lengths on the bioavailability 5-DN. 5-DN was encapsulated in medium chain triglycerides (MCT) or canola oil (long chain triglycerides, LCT) based nanoemulsion. They were subject to a simulated gastrointestinal digestion model. Finally, the mixed micelle phase was applied to Caco-2 monolayer cell model that mimics intestinal absorption. Higher bioaccessibility of 5-DN was found in MCT nanoemulsion than canola nanoemulsion, 13% vs.7% respectively. However, only 30% 5-DN crossed Caco-2 monolayer while half of them were metabolized for MCT nanoemulsion, up to 60% 5-DN and only 10% were metabolized in canola nanoemulsion. Results also demonstrated more lipid droplets and CMs were formed by canola nanoemulsion, which were responsible for transportation of 5-DN to the lymph. In conclusion, although for lipophilic components like 5-DN, relatively higher bioaccessibility can be achieved by MCT-based nanoemulsion, LCT-based emulsion was more potent in enhancing the bioavailability through increased lymphatic transport. Lipids especially the ones with polyunsaturated long chain fatty acids (PUFA) are very susceptible to oxidation. Ingestion of oxidized lipids is associated with all kinds of health risk: diabetes, tumor development and atherosclerosis. Meanwhile, the oxidation of lipids may affect the absorption of lipophilic bioactive components in foods. We compared the effect of oxidized and unoxidized PUFA, linoleic acid (LA) on the transport of the highly lipophilic compound 5-hydroxy 6,7,8,4' tetramethoxylflavone (5-DMT) by a Caco-2 cell model. Results turned out that unoxidized LA improved bioavailability of 5-DMT by stimulating CMs. Oxidized LA also showed an effect of improving transport of 5-DMT. However, it significantly affected the morphology of Caco-2 monolayer especially the tight junction. Accordingly, the transport pathway could be altered compared to the unoxidized LA, which will ultimately influence the distribution and metabolism fate of lipophilic components in the human body. Recently, the fate of inorganic nanoparticles in foods after ingestion has been attracted highly attention. Based on the above model and experimental methods, we also investigate the transport and toxicity of inorganic nanoparticle (AuNPs) on Caco-2 cell monolayer. AuNPs with different size (15nm, 50nm and 100nm) were applied. Our results demonstrated that more amount of gold was retained in the monolayer and higher toxicity was caused for larger size of AuNPs. Besides, mixed micelles greatly improve the secretion of AuNPs. The influence may be associated with formation abundant lipid droplets and CMs in the monolayer after fatty acids were taken in.
