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Author: Sarah Caroline Clement
Publisher:
ISBN:
Category :
Languages : en
Pages : 327
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Book Description
Treatment of pediatric malignancies has advanced substantially over the past several decades, resulting in a rapidly growing group of long-term childhood cancer survivors (CCS). Improved survival leads to an increasing number of individuals who may be at increased risk of substantial morbidity and even mortality as a direct or indirect consequence of their prior cancer therapy. Moreover, many CCS face lifelong health-related challenges after curative treatment of a childhood malignancy. Around 73% of the survivors will experience at least one chronic health-condition within 30 years of their cancer diagnosis, with a 42% cumulative incidence rate for severe, disabling, or life-threatening conditions or death due to a chronic disease. Endocrine disorders are common in CCS, and may not only play a central role in long-term health and wellbeing, but can also significantly diminish short-term health, especially during childhood. In CCS, endocrine integrity is essential for adequate recovery, for development and growth and optimal daily (school) life participation. As in many late adverse effects in CCS, endocrine disturbances are most often related to cancer treatment. Particularly patients receiving radiation therapy and alkylating chemotherapy are at high risk of developing endocrinopathies. In addition to their anti-carcinogenic effects, these therapies may cause direct injury to the hypothalamic-pituitary axis, thyroid gland, and the gonads. The current thesis focuses primarily on the etiology, epidemiology, risk factors and optimal surveillance strategy of diverse endocrine disorders in survivors of a childhood malignancy.
Author: Sarah Caroline Clement
Publisher:
ISBN:
Category :
Languages : en
Pages : 327
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Book Description
Treatment of pediatric malignancies has advanced substantially over the past several decades, resulting in a rapidly growing group of long-term childhood cancer survivors (CCS). Improved survival leads to an increasing number of individuals who may be at increased risk of substantial morbidity and even mortality as a direct or indirect consequence of their prior cancer therapy. Moreover, many CCS face lifelong health-related challenges after curative treatment of a childhood malignancy. Around 73% of the survivors will experience at least one chronic health-condition within 30 years of their cancer diagnosis, with a 42% cumulative incidence rate for severe, disabling, or life-threatening conditions or death due to a chronic disease. Endocrine disorders are common in CCS, and may not only play a central role in long-term health and wellbeing, but can also significantly diminish short-term health, especially during childhood. In CCS, endocrine integrity is essential for adequate recovery, for development and growth and optimal daily (school) life participation. As in many late adverse effects in CCS, endocrine disturbances are most often related to cancer treatment. Particularly patients receiving radiation therapy and alkylating chemotherapy are at high risk of developing endocrinopathies. In addition to their anti-carcinogenic effects, these therapies may cause direct injury to the hypothalamic-pituitary axis, thyroid gland, and the gonads. The current thesis focuses primarily on the etiology, epidemiology, risk factors and optimal surveillance strategy of diverse endocrine disorders in survivors of a childhood malignancy.
Author: Charles A. Sklar
Publisher: S. Karger AG (Switzerland)
ISBN: 9783318065664
Category :
Languages : en
Pages : 0
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Book Description
This special topic issue addresses the most common endocrine and metabolic complications observed in cancer survivors. It gives an overview to orient endocrinologists to common cancer diagnoses and the therapies most often associated with adverse endocrine outcomes. Additionally, it focuses on the important issues of impaired linear growth, hypogonadism in males and females, disorders of the thyroid gland, diabetes mellitus and the metabolic syndrome, hypothalamic obesity, and disorders of the bone. These state-of-the-art reviews will hopefully assist clinicians in diagnosing and managing the various endocrine disorders experienced by survivors. The goal is to improve quality of life and to reduce morbidity and mortality in a vulnerable population. This publication is a valuable resource for pediatric, adult, and generalist providers caring for childhood cancer and brain tumor survivors.
Author: W. H. B. Wallace
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805590377
Category : Medical
Languages : en
Pages : 197
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Book Description
Continuing advances in the management of childhood malignancies result in a rapidly growing number of childhood cancer survivors. However, many of them experience treatment-induced 'late effects' including a significant number of endocrine dysfunctions.In this book experts in the field of late effects of childhood cancer treatment offer clinical insight into pertinent issues such as the impact of cancer therapies on growth, puberty and hypothalamic and pituitary function, male and female fertility, obesity, and metabolic and bone problems.Multidisciplinary long-term follow-up of these patients is essential to monitor, treat and prevent morbidity. Therefore this volume is of great interest to pediatric endocrinologists and oncologists, adult and reproductive endocrinologists, primary care practitioners, nurses and nurse practitioners as well as others involved in planning and delivering the holistic care which this increasingly numerous and important group of patients requires.
Author: Francesco Felicetti (Oncologist)
Publisher:
ISBN: 9783318067903
Category :
Languages : en
Pages : 162
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Book Description
This book analyzes in detail all aspects related to endocrine and metabolic late effects observed in patients treated for cancer, both in childhood and adulthood. The chapters focusing on the possible pathogenic mechanisms of late effects (i.e., premature aging and chronic inflammation) and on bone health in cancer survivors are particularly interesting and innovative. The volume also deals with hypothalamic-pituitary, thyroid and gonadal disorders, including infertility and how to prevent it. Finally, the relationship between metabolic alterations and cardiovascular diseases in cancer survivors is addressed. Thanks to advances in cancer treatment and supportive care, the five-year survival rate of cancer patients is constantly increasing. However, this undisputable success of medicine has a flip side: the late adverse effects of anticancer therapies. Pediatric oncologists were the first to cope with late complications of treatments, but today also adult oncologists and onco-hematologists recognize the relevance of this issue. Even though late effects observed in cancer survivors can affect any organ or system, endocrine and metabolic dysfunctions are the most frequently reported. Endocrine complications rarely influence life expectancy of cancer survivors, but they can significantly impact morbidity and quality of life. Among endocrine adverse effects, severe hypothalamic damage may be considered the most harmful in survivors, leading to morbid obesity, propensity to metabolic syndrome and cardiovascular disease. This book aims to disseminate the knowledge about endocrine and metabolic adverse effects of cancer therapies and about survivorship care. Since the number of cancer survivors is steadily growing in the general population, this publication is intended not only for endocrinologists but also for oncologists, onco-hematologists, internists, pediatric specialists in those areas and general practitioners, with the aim to better counsel and monitor cancer survivors.
Author: Malabika Behera
Publisher: Open Dissertation Press
ISBN: 9781361353745
Category :
Languages : en
Pages :
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Book Description
This dissertation, "Long Term Endocrine Sequelae of Childhood Cancer Survivors" by Malabika, Behera, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Background: Newer multimodality therapeutic interventions have resulted in dramatic survival rates in childhood cancers. However diverse treatment related morbidities affect the long term survivors. An Endocrine complication comprises 20-40% of these morbidities and affects the hypothalamic pituitary axis, growth, pubertal progression, fertility, bone health and glucose homeostasis. Objectives: The aim of our study was to enumerate and evaluate the frequency of endocrine complications arising as a late effect of treatment in childhood cancer survivors. Risk factors likely to be associated with these complications were also evaluated. Methodology: Retrospective analysis of medical records from the Long Term Endocrine Follow up clinic in the Department of Paediatrics and Adolescent Medicine of Queen Mary Hospital was done. Patients with a primary diagnosis of Cancer and Langerhans cell histiocytosis with endocrine sequelae arising from various treatment modalities who have survived 5 years after diagnosis were included in the study. Those who had endocrine complications arising from various treatment modalities for Thalassemia's, Immunodeficiency's were excluded from the study Results: 135 cases were included in the study and 27 were excluded. Leukemia and Brain tumor survivors were the majority accounting for 40% and 26.67% respectively. ALL formed majority of leukemia survivors, Medulloblastoma survivors accounted for 50% of brain tumor survivors. Most common endocrine problem was Hypogonadism in 51.1% of cases, followed by growth disturbances in 40%, Thyroid dysfunction in 23% and Hyperlipidemias in 18.5%. Pubertal problems, Central Diabetes Insipidus, Adrenal insufficiency, Obesity, Altered glucose homeostasis were rest of the problems in small frequencies. PHGN (Primary Hypogonadism) was present in 91.3% and mostly in prepubertal males. PHGN was statistically associated with Leukemia survivors with OR-2.06 (1.02- 4.15), p value 0.04. The risk factors associated were exposure to alkylating agents, radiotherapy, TBI prior to transplant. SHGN (Secondary HGN) was statistically associated with Brain tumor survivor OR - 15.8 (1.7-140.5), p value 0.013. Cranial irradiation was the major risk for SHGN. PGV (Poor growth velocity) was the major growth problem.GHD (Growth Hormone Deficiency) had a highly significant association with Brain tumors (p value ˂ 0.0001), and significantly associated when all 3 modalities of treatment given together (p value 0.01). Risk factors for GHD were cranial radiotherapy, exposure to cyclophosphamide and TBI. PH (Primary Hypothyroidism) had highly significant association with craniospinal radiotherapy (p value ˂ 0.0001), and significantly associated with brain tumors. Similar results were observed in patients of CH (Central Hypothyroidism). Hyperlipidemias were present in 18% with no statistical correlation with the type of cancer. Brain tumor survivors had a significant association of GHD, PH, CH, SHGN and CDI. Leukemia survivors had significant association with GHD and PHGN. Conclusions: Endocrine problems are frequent manifestations of late effects of cancer related treatments. Early detection and intervention of these potentially treatable problems could be done through structured long term surveillance. Increasing awareness among health care professionals to anticipate problems in suspected patients and education of patients wou
Author: Mehul T. Dattani
Publisher: John Wiley & Sons
ISBN: 1119152682
Category : Medical
Languages : en
Pages : 816
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Book Description
The seventh edition of Brook's Clinical Pediatric Endocrinology has been compiled by an experienced editorial team and internationally renowned contributors; it presents basic science and clinical management of endocrine disorders for all involved in the care of children and adolescents. It provides treatments for a variety of hormonal diseases, including diabetes and hypoglycaemia, growth problems, thyroid disease and disorders of puberty, sexual differentiation, calcium metabolism, steroid metabolism and hypopituitarism.
Author: Daniel Green
Publisher: CRC Press
ISBN: 1444114042
Category : Medical
Languages : en
Pages : 423
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Book Description
The treatment of childhood cancer has become increasingly successful over the last forty years, and during the last two decades in particular, and the overall cure rate is now 60-70%. This, in turn, has introduced new issues for the clinician as the number of long-term survivors has increased. Some of the therapies that have contributed most to the
Author: Dick F. Swaab
Publisher: Elsevier
ISBN: 0128206845
Category : Science
Languages : en
Pages : 570
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Book Description
The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders. Discusses the importance of the hypothalamus in human growth and development Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders Includes metabolic and eating disorders Identifies mechanisms of disease action and etiology Provides best practice information for assessment and treatment
Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 194
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Book Description
Author: Jörn D. Beck
Publisher: Springer Nature
ISBN: 3030491404
Category : Medical
Languages : en
Pages : 419
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Book Description
This comprehensive guide describes the aftercare that is appropriate in young cancer patients and discusses in detail the risk and detection of treatment sequelae. It explains the impacts on body and mind of both the disease itself and the different risk-adapted cancer treatments currently in use. Clear guidance is provided on diagnosis and management of the principal treatment-related toxicities in different organs and organ systems and for a wide variety of tumor types. In addition, the role of genetic polymorphisms in the development of adverse therapy-related outcomes is explored, and advice offered on genetic counselling. As the number of long-term survivors of childhood cancer and of cancer in young adults continues to grow, so issues surrounding potential sequelae, second malignancies, and quality of life are becoming ever more important. All practitioners involved in the care of young cancer patients will find this book to be a helpful source of up-to-date information and assistance.
