Effects of a Novel, High-intensity Aerobic Interval Training Program on Diastolic and Cardiovascular Function in Patients with Heart Failure with Preserved Ejection Fraction PDF Download
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Author: Siddhartha Angadi
Publisher:
ISBN:
Category : Heart failure
Languages : en
Pages : 78
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Book Description
Heart failure is a major worldwide health concern and is the leading cause of hospitalization among elderly Americans. Approximately 50% of those diagnosed with heart failure have heart failure with preserved ejection fraction (HFPEF). HFPEF presents a therapeutic dilemma because pharmacological strategies that are effective for the treatment of heart failure and reduced ejection fraction have failed to show benefit in HFPEF. Long term moderate intensity exercise programs have been shown to improve diastolic function in patients HFPEF. High intensity interval training (HIIT) has been shown to improve diastolic function in patients with heart failure and reduced ejection fraction. However, the effects of high intensity interval training in patients with HFPEF are unknown. Fourteen patients with HFPEF were randomized to either: (1) a novel program of high-intensity aerobic interval training (n = 8), or (2) a commonly prescribed program of moderate-intensity (MOD) aerobic exercise training (n = 6). Before and after four weeks of exercise training, patients underwent a treadmill graded exercise test for the determination of peak oxygen uptake (VO2peak), a brachial artery reactivity test for assessment of endothelium-dependent flow-mediated dilation (BAFMD), aortic pulse wave velocity assessment as an index of vascular stiffness and two-dimensional echocardiography for assessment of left ventricular diastolic and systolic function. I hypothesized that (1) high-intensity aerobic interval training would result in superior improvements in FMD, aortic pulse wave velocity, VO2peak, diastolic function and, (2) changes in these parameters would be correlated with changes in VO2peak. The principal findings of the study were that a one month long high intensity interval training program resulted in significant improvements in diastolic function as measured by two-dimensional echocardiography [pre diastolic dysfunction (DD) grade - 2.13 ± 0.4 vs. post DD grade - 1.25 ± 0.7, p = 0.03]. The left atrial volume index was reduced in the HIIT group compared to MOD ( - 4.4 ± 6.2 ml/m2 vs. 5.8 ± 10.7 ml/m2, p = 0.02). Early mitral flow (E) improved in the HIIT group (pre - 0.93 ± 0.2 m/s vs. post - 0.78 ± 0.3 m/s, p = 0.03). A significant inverse correlation was observed between change in BAFMD and change in diastolic dysfunction grade (r = - 0.585, p = 0.028) when all the data were pooled. HIIT appears to be a time-efficient and safe strategy for improving diastolic function in patients with heart failure and preserved ejection fraction. These data may have implications for cardiovascular risk reduction in this population.
Author: Siddhartha Angadi
Publisher:
ISBN:
Category : Heart failure
Languages : en
Pages : 78
Get Book Here
Book Description
Heart failure is a major worldwide health concern and is the leading cause of hospitalization among elderly Americans. Approximately 50% of those diagnosed with heart failure have heart failure with preserved ejection fraction (HFPEF). HFPEF presents a therapeutic dilemma because pharmacological strategies that are effective for the treatment of heart failure and reduced ejection fraction have failed to show benefit in HFPEF. Long term moderate intensity exercise programs have been shown to improve diastolic function in patients HFPEF. High intensity interval training (HIIT) has been shown to improve diastolic function in patients with heart failure and reduced ejection fraction. However, the effects of high intensity interval training in patients with HFPEF are unknown. Fourteen patients with HFPEF were randomized to either: (1) a novel program of high-intensity aerobic interval training (n = 8), or (2) a commonly prescribed program of moderate-intensity (MOD) aerobic exercise training (n = 6). Before and after four weeks of exercise training, patients underwent a treadmill graded exercise test for the determination of peak oxygen uptake (VO2peak), a brachial artery reactivity test for assessment of endothelium-dependent flow-mediated dilation (BAFMD), aortic pulse wave velocity assessment as an index of vascular stiffness and two-dimensional echocardiography for assessment of left ventricular diastolic and systolic function. I hypothesized that (1) high-intensity aerobic interval training would result in superior improvements in FMD, aortic pulse wave velocity, VO2peak, diastolic function and, (2) changes in these parameters would be correlated with changes in VO2peak. The principal findings of the study were that a one month long high intensity interval training program resulted in significant improvements in diastolic function as measured by two-dimensional echocardiography [pre diastolic dysfunction (DD) grade - 2.13 ± 0.4 vs. post DD grade - 1.25 ± 0.7, p = 0.03]. The left atrial volume index was reduced in the HIIT group compared to MOD ( - 4.4 ± 6.2 ml/m2 vs. 5.8 ± 10.7 ml/m2, p = 0.02). Early mitral flow (E) improved in the HIIT group (pre - 0.93 ± 0.2 m/s vs. post - 0.78 ± 0.3 m/s, p = 0.03). A significant inverse correlation was observed between change in BAFMD and change in diastolic dysfunction grade (r = - 0.585, p = 0.028) when all the data were pooled. HIIT appears to be a time-efficient and safe strategy for improving diastolic function in patients with heart failure and preserved ejection fraction. These data may have implications for cardiovascular risk reduction in this population.
Author: Scott L. Hummel
Publisher: Elsevier Health Sciences
ISBN: 0323939821
Category : Medical
Languages : en
Pages : 185
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Book Description
In this issue of Cardiology Clinics, guest editors Drs. Scott Hummel and Matthew Konerman bring their considerable expertise to the topic of Heart Failure with Preserved Ejection Fraction. Top experts in the field cover key topics such as risk factors for heart failure with preserved ejection fraction (HFpEF); cardiopulmonary stress testing in HFpEF; hemodynamic assessment in HFpEF; the role of multi-modality imaging in the evaluation of HFpEF; and more. Contains 13 relevant, practice-oriented topics including pharmacologic, non-pharmacologic, and device therapy for HFpEF; geriatric domains in patients with HFpEF; pulmonary hypertension in HFpEF; infiltrative, genetic, and other non-standard causes of HFpEF; echocardiography in HFpEF; and more. Provides in-depth clinical reviews on heart failure with preserved ejection fraction, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Author: Naranjan S. Dhalla
Publisher: Lippincott Williams & Wilkins
ISBN:
Category : Medical
Languages : en
Pages : 570
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Book Description
Author: Joel A. Kaplan
Publisher: Elsevier Health Sciences
ISBN: 0323463010
Category : Medical
Languages : en
Pages : 1691
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Book Description
Now in a revised and expanded 7th Edition, Kaplan's Cardiac Anesthesia helps you optimize perioperative outcomes for patients undergoing both cardiac and noncardiac surgery. Dr. Joel L. Kaplan, along with associate editors, Drs. John G. T. Augoustides, David L. Reich, and Gerard R. Manecke, guide you through today's clinical challenges, including the newest approaches to perioperative assessment and management, state-of-the art diagnostic techniques, and cardiovascular and coronary physiology. - Complete coverage of echocardiography and current monitoring techniques. - Guidance from today's leaders in cardiac anesthesia, helping you avoid complications and ensure maximum patient safety. - More than 800 full-color illustrations. - A new section on anesthetic management of the cardiac patient undergoing noncardiac surgery. - New availability as an eBook download for use the in OR. - Online-only features, including quarterly updates, an ECG atlas...an increased number of videos, including 2-D and 3-D TEE techniques in real time...and an Annual Year End Highlight from the Journal of Cardiovascular Anesthesia that's posted each February. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.
Author: Geu-Ru Hong
Publisher: Elsevier Health Sciences
ISBN: 0323835392
Category : Medical
Languages : en
Pages : 225
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Book Description
This issue of Heart Failure Clinics, guest edited by Geu-Ru Hong, will cover key topics in Heart Failure with Preserved Ejection Fraction. This issue is one of four selected each year by our series consulting editor, Dr. Eduardo Bossone. Topics discussed in this issue will include: Current Trends and Outcomes of Heart Failure with Preserved Ejection Fraction, Pathogenesis and Phenotypes of Heart Failure with Preserved Ejection Fraction, Hypertension and Heart Failure with Preserved Ejection Fraction, Obesity in Heart Failure with Preserved Ejection Fraction, Noninvasive Hemodynamic Evaluation at rest in Heart Failure with Preserved Ejection Fraction, Clinical Phenogroups in Heart?Failure With Preserved Ejection Fraction and response to therapy, among others.
Author: Richard Yang Cao
Publisher: Frontiers Media SA
ISBN: 2889748472
Category : Medical
Languages : en
Pages : 273
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Book Description
Author: Carolyn S.P. Lam
Publisher: Elsevier Health Sciences
ISBN: 0323311822
Category : Medical
Languages : en
Pages : 185
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Book Description
This issue of Heart Failure Clinics examines Heart Failure with Preserved Ejection Fraction (HFPEF). The followings aspects of HFPEF are addressed: epidemiology, etiologic factors and pathophysiology, diagnosis, clinical spectrum, imaging, invasive hemodynamic characterization, exercise physiology, natriuretic peptides, novel biomarkers, differential diagnoses and comorbidities, outcomes, clinical trials, current therapeutic approach, and novel therapeutic targets.
Author: G. Michael Felker
Publisher: Elsevier Health Sciences
ISBN: 0323609880
Category : Medical
Languages : en
Pages : 937
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Book Description
Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).
Author: Gianluca Iacobellis
Publisher: Springer Nature
ISBN: 3030405702
Category : Medical
Languages : en
Pages : 191
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Book Description
This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.
Author: Matthijs Blankesteijn
Publisher: Academic Press
ISBN: 0128004851
Category : Medical
Languages : en
Pages : 221
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Book Description
Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure's breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. - Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment - Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure - Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure - Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases
