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Author: Josef T. Kittler
Publisher: CRC Press
ISBN: 0203486285
Category : Medical
Languages : en
Pages : 339
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Book Description
Exploring the diverse tools and technologies used to study synaptic processes, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology delineates techniques, methods, and conceptual advances for studying neurotransmitter receptors and other synaptic proteins. It describes a broad range of molecular, biochemica
Author: Josef T. Kittler
Publisher: CRC Press
ISBN: 0203486285
Category : Medical
Languages : en
Pages : 339
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Book Description
Exploring the diverse tools and technologies used to study synaptic processes, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology delineates techniques, methods, and conceptual advances for studying neurotransmitter receptors and other synaptic proteins. It describes a broad range of molecular, biochemica
Author: Stuart Warren
Publisher: Stuart Warren
ISBN: 9781637608296
Category :
Languages : en
Pages : 390
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Book Description
Eight hundred years after humanity's extinction, Aia, an android, awakens in the tundra of Alberta, Canada. It has no knowledge of the time before, and the world ahead holds the answers it seeks. What happened to its creator? Will it find its place in machine society? As Aia encounters civilization, it quickly learns that self-actualization is not for all: machines live within a caste system, bound to their peers with no means of promotion. Within the eclectic city-state of HUB 9, situated in the idyllic ruins of San Francisco, Aia is indentured to a sewage processing facility and nearly gives up hope until it is mysteriously promoted from its current assignment by Donnie Eberstark, a member of the social elite bent on preserving humanity's legacy and culture. While discovering where it fits in, Aia becomes embroiled in a high stakes political movement that will decide the future of machine-kind. Immersive, meditative, and witty, Stuart Warren's second full-length novel Dynamic Synapse Protocol explores the aftermath of humanity's fall and the difficult choice between exalting the past or embracing the future.
Author: Wulfram Gerstner
Publisher: Cambridge University Press
ISBN: 1107060834
Category : Computers
Languages : en
Pages : 591
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Book Description
This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
Author: Cosima T. Baldari
Publisher: Humana
ISBN: 9781071631379
Category : Science
Languages : en
Pages : 0
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Book Description
This new collection features the most up-to-date essential protocols that are currently being used to study the immune synapse. Beginning with methods for making biophysical measurements, the volume continues by covering the cell biology of synapses, methods for advanced substrate engineering, mechanobiology topics, new technologies to describe and manipulate synaptic components, as well as methods related to sites of action and immunotherapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and fully updated, The Immune Synapse: Methods and Protocols, Second Edition serves as an ideal practical guide for researchers working in this dynamic field. Chapters 5, 11,18, 27, 30, and 32 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Jannik Luboeinski
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 201
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Book Description
Memory serves to process and store information about experiences such that this information can be used in future situations. The transfer from transient storage into long-term memory, which retains information for hours, days, and even years, is called consolidation. In brains, information is primarily stored via alteration of synapses, so-called synaptic plasticity. While these changes are at first in a transient early phase, they can be transferred to a late phase, meaning that they become stabilized over the course of several hours. This stabilization has been explained by so-called synaptic tagging and capture (STC) mechanisms. To store and recall memory representations, emergent dynamics arise from the synaptic structure of recurrent networks of neurons. This happens through so-called cell assemblies, which feature particularly strong synapses. It has been proposed that the stabilization of such cell assemblies by STC corresponds to so-called synaptic consolidation, which is observed in humans and other animals in the first hours after acquiring a new memory. The exact connection between the physiological mechanisms of STC and memory consolidation remains, however, unclear. It is equally unknown which influence STC mechanisms exert on further cognitive functions that guide behavior. On timescales of minutes to hours (that means, the timescales of STC) such functions include memory improvement, modification of memories, interference and enhancement of similar memories, and transient priming of certain memories. Thus, diverse memory dynamics may be linked to STC, which can be investigated by employing theoretical methods based on experimental data from the neuronal and the behavioral level. In this thesis, we present a theoretical model of STC-based memory consolidation in recurrent networks of spiking neurons, which are particularly suited to reproduce biologically realistic dynamics. Furthermore, we combine the STC mechanisms with calcium dynamics, which have been found to guide the major processes of early-phase synaptic plasticity in vivo. In three included research articles as well as additional sections, we develop this model and investigate how it can account for a variety of behavioral effects. We find that the model enables the robust implementation of the cognitive memory functions mentioned above. The main steps to this are: 1. demonstrating the formation, consolidation, and improvement of memories represented by cell assemblies, 2. showing that neuromodulator-dependent STC can retroactively control whether information is stored in a temporal or rate-based neural code, and 3. examining interaction of multiple cell assemblies with transient and attractor dynamics in different organizational paradigms. In summary, we demonstrate several ways by which STC controls the late-phase synaptic structure of cell assemblies. Linking these structures to functional dynamics, we show that our STC-based model implements functionality that can be related to long-term memory. Thereby, we provide a basis for the mechanistic explanation of various neuropsychological effects. Keywords: synaptic plasticity; synaptic tagging and capture; spiking recurrent neural networks; memory consolidation; long-term memory
Author: Alexandros Poulopoulos
Publisher: Humana
ISBN: 9781493966868
Category : Medical
Languages : en
Pages : 0
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Book Description
This detailed volume collects protocols for experimentation into how neurons connect to produce the extraordinary functionalities of the nervous system. Contributed by experts and pioneers in their respective techniques, the book covers synapses in the brain and in culture, their constituents, their structures, their dynamics, and the assemblies they form, all in the structure of a laboratory guide. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synapse Development: Methods and Protocols serves as an ideal guide to minimizing the barrier to entry for the integration of new approaches with existing expertise, producing syntheses that will foster novel perspectives on the many ways in which synapses form, transform, and transmit.
Author: Shiva K. Tyagarajan
Publisher: Frontiers Media SA
ISBN: 2889717666
Category : Science
Languages : en
Pages : 171
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Book Description
Author: Si Wu
Publisher: Frontiers E-books
ISBN: 2889193837
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 179
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Book Description
Author: Peter Molnar
Publisher: Springer Science & Business Media
ISBN: 1603270906
Category : Medical
Languages : en
Pages : 319
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Book Description
Patch Clamp Methods and Protocols surveys the typical patch clamp applications and advises scientists on identifying problems and selecting the best technique in each instance. The experiments described require a basic level of electrophysiological training and aid the researcher in pursuing new areas of electrophysiology and using the patch clamp technique effectively. Patch Clamp Methods and Protocols is divided into three sections that cover the major areas of patch clamp application: Pharmacology, Physiology, and Biophysics. The first section provides examples and step by step instructions on how to use whole-cell and single-channel patch clamp methods for testing drugs in industrial settings. The second section provides a wide selection of patch clamp applications in physiological studies. The last part focuses on the biophysical applications of the patch clamp method using single channel recordings or statistical analysis of whole-cell currents in order to obtain parameters that describe ion channel properties or transmitter release. Individual techniques are explored within the area that they are applied most often. Researchers will find Patch Clamp Methods and Protocols to be an invaluable aid in the design and execution of a wide variety of patch clamp experiments, both on their own and in conjunction with other state-of-the-art methodologies.
Author: Maria Elisa Calcagnotto
Publisher: Frontiers Media SA
ISBN: 2889458911
Category :
Languages : en
Pages : 136
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Book Description
