The Neurobiology of Aging and Alzheimer Disease in Down Syndrome PDF Download
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Author: Elizabeth Head
Publisher: Academic Press
ISBN: 0128188464
Category : Medical
Languages : en
Pages : 354
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Book Description
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Author: Elizabeth Head
Publisher: Academic Press
ISBN: 0128188464
Category : Medical
Languages : en
Pages : 354
Get Book Here
Book Description
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Author: Vee P. Prasher
Publisher: Radcliffe Publishing
ISBN: 9781857756371
Category : Alzheimer's disease
Languages : en
Pages : 206
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Book Description
Addresses the underlying biological abnormalities of Dementia in Alzheimer's Disease (DAD) in people with Down syndrome. Brings together recent research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer's disease in older adults with Down syndrome.
Author: Vee P. Prasher
Publisher: Springer Science & Business Media
ISBN: 1848002491
Category : Medical
Languages : en
Pages : 222
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Book Description
This book reviews important neuropsychological measures currently used in the assessment of dementia by the principal clinicians and researchers associated with the test, offering practical guidance on each test along with an analysis of its limitations.
Author: Karen Watchman
Publisher: Jessica Kingsley Publishers
ISBN: 1784501840
Category : Family & Relationships
Languages : en
Pages : 122
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Book Description
Selected for Reading Well for Dementia 2024: endorsed by health experts, charities and people affected by dementia. Drawing on the author's first-hand experiences with families, this book provides crucial, accessible information and answers the difficult questions that often arise when a family member with an intellectual disability is diagnosed with dementia. Linking directly to policy and practice in both dementia and intellectual disability care, this book takes an outcome-focussed approach to support short, medium and long-term planning. With a particular emphasis on communication, the author seeks to ensure that families and organisations are able to converse effectively about a relative's health and care. The book looks at how to recognise when changes in the health of a relative with an intellectual disability could indicate the onset of dementia, as well as addressing common concerns surrounding living situations, medication and care plans. Each chapter is structured to identify strategies for support whilst working towards outcomes identified by families as dementia progresses.
Author: Karen Dodd
Publisher:
ISBN: 9781905218080
Category : Dementia
Languages : en
Pages : 136
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Book Description
A resource book for family carers, staff and other professionals to help them care more effectively for people with Down's syndrome and dementia.
Author: Bob Dawson
Publisher: Sharing Good Practice
ISBN: 9781789631678
Category : Health & Fitness
Languages : en
Pages : 86
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Book Description
A guide for carers who are supporting people with Down Syndrome who develop dementia.
Author: Marie-Claude Potier
Publisher: Frontiers Media SA
ISBN: 2889450457
Category :
Languages : en
Pages : 183
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Book Description
Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.
Author: Richard W. Newton
Publisher: John Wiley & Sons
ISBN: 9781909962477
Category : Medical
Languages : en
Pages : 0
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Book Description
Down syndrome remains the most common recognisable form of intellectual disability. The challenge for doctors today is how to capture the rapidly expanding body of scientific knowledge and devise models of care to meet the needs of individuals and their families. Down syndrome; Clinical Perspectives provides doctors and other health professionals with the information they need to address the challenges that can present in the management of syndrome. Chapters written by internationally respected paediatricians with a special interest in Down syndrome, cover Down syndrome comorbidities, such hearing problems, gastrointestinal disorders, congenital heart diseases, as well as the underlying biology and new developments in molecular genetics. Contributions from the UK Down Syndrome Association and Down Syndrome Medical Interest Group define how doctors can work effectively with other professionals to improve health care provisions for this group. Each chapter is illustrated by informative case scenarios and answers to FAQs from parents and carers.
Author: Sarah Ball
Publisher: Cambridge University Press
ISBN: 9780521547949
Category : Medical
Languages : en
Pages : 130
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Book Description
CAMDEX-DS is a comprehensive assessment tool for diagnosing dementia in people with Down's syndrome (a group known to be at particular risk of dementia). Based upon CAMDEX-R, CAMDEX-DS has been modified for use with intellectual disability. In order to differentiate decline due to dementia or other mental disorders from pre-existing impairment, particular emphasis has been placed on establishing change from the individual's best level of functioning. The pack is comprised of a structured informant interview, a direct assessment of the patient/participant (CAMCOG), and guidance for diagnosis and post-diagnosis intervention, providing a reliable way to identify dementia (and to differentiate it from other common disorders). It may be used in community settings by mental health professionals as part of the diagnostic process, or to formalize diagnosis in the context of research. Use of the CAMCOG provides the means for ongoing neuropsychological evaluation and informs future support and intervention strategies.
Author: Matthew P. Janicki
Publisher: Routledge
ISBN: 1317823818
Category : Psychology
Languages : en
Pages : 534
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Book Description
This definitive handbook assembles the most recent advances in knowledge about dementia, Alzheimer Disease, and related disorders as they affect persons with intellectual disabilities. Diagnosis, assessment, treatment, and management and care practices are detailed in a practical manner making this a useful tool to both students and trained professionals. After an introduction to the subject, the book begins with persoanl accounts of three affected individuals whose signs of dementia are described from clinical, family member, and care-provider perspectives, respectively. The biology and physiology of dementia, as well as the neurological and medical complications associated with it, are then provided in Parts Two, three, and Four. The application and practical perspectives of this handbook are enhanced in Part Five which details the best practices available to meet the needs and challenges involved in care and quality of life issues. The challenge raised by the rapidly growing number of aging individuals with intellectual disabilities forms the basis for the final part of the volume, an analysis and presentation of rarely addressed policy issues. Extensive resource information and a comprehensive glossary contribute to the useful nature of this handbook. Practitioners, service providers, educators and students will benefit from the accessability and practicality if this text as well as the breadth and depth of knowledge of the editors and contributors.
