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Author: Edward St. Aubyn
Publisher: Farrar, Straus and Giroux
ISBN: 0374717478
Category : Fiction
Languages : en
Pages : 256
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Book Description
Double Blind follows three close friends and their circle through a year of extraordinary transformation. Set inLondon, Cap d'Antibes, Big Sur, and a rewilded corner of Sussex, this thrilling, ambitious novel is about the headlong pursuit of knowledge—for the purposes of pleasure, revelation, money, sanity, or survival—and the consequences of fleeing from what we know about others and ourselves. When Olivia meets a new lover just as she is welcoming her best friend, Lucy, back from New York, her dedicated academic life expands precipitously. Her connection to Francis, a committed naturalist living off the grid, is immediate and startling. Eager to involve Lucy in her joy, Olivia introduces the two—but Lucy has received shocking news of her own that binds the trio unusually close. Over the months that follow, Lucy’s boss, Hunter, Olivia’s psychoanalyst parents, and a young man named Sebastian are pulled into the friends’ orbit, and not one of them will emerge unchanged. Expansive, playful, and compassionate, Edward St. Aubyn's Double Blind investigates themes of inheritance, determinism, freedom, consciousness, and the stories we tell about ourselves. It is as compelling about ecology, psychoanalysis, genetics, and neuroscience as it is about love, fear, and courage. Most of all, it is a perfect expression of the interconnections it sets out to examine, and a moving evocation of an imagined world that is deeply intelligent, often tender, curious, and very much alive.
Author: Edward St. Aubyn
Publisher: Farrar, Straus and Giroux
ISBN: 0374717478
Category : Fiction
Languages : en
Pages : 256
Get Book
Book Description
Double Blind follows three close friends and their circle through a year of extraordinary transformation. Set inLondon, Cap d'Antibes, Big Sur, and a rewilded corner of Sussex, this thrilling, ambitious novel is about the headlong pursuit of knowledge—for the purposes of pleasure, revelation, money, sanity, or survival—and the consequences of fleeing from what we know about others and ourselves. When Olivia meets a new lover just as she is welcoming her best friend, Lucy, back from New York, her dedicated academic life expands precipitously. Her connection to Francis, a committed naturalist living off the grid, is immediate and startling. Eager to involve Lucy in her joy, Olivia introduces the two—but Lucy has received shocking news of her own that binds the trio unusually close. Over the months that follow, Lucy’s boss, Hunter, Olivia’s psychoanalyst parents, and a young man named Sebastian are pulled into the friends’ orbit, and not one of them will emerge unchanged. Expansive, playful, and compassionate, Edward St. Aubyn's Double Blind investigates themes of inheritance, determinism, freedom, consciousness, and the stories we tell about ourselves. It is as compelling about ecology, psychoanalysis, genetics, and neuroscience as it is about love, fear, and courage. Most of all, it is a perfect expression of the interconnections it sets out to examine, and a moving evocation of an imagined world that is deeply intelligent, often tender, curious, and very much alive.
Author: Ann Aguirre
Publisher: Penguin
ISBN: 1101140364
Category : Fiction
Languages : en
Pages : 276
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Book Description
View our feature on Ann Aguirre’s Doubleblind.As a “Jumper” who navigates ships through grimspace, Sirantha Jax is used to kicking ass. So why is she suddenly chosen as an ambassador of peace?
Author: Peter G. Smith
Publisher: Oxford University Press, USA
ISBN: 0198732864
Category : Medical
Languages : en
Pages : 479
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Book Description
"IEA, International Epidemiological Association, Welcome Trust."
Author: S. Campbell
Publisher: Springer Science & Business Media
ISBN: 9401161658
Category : Medical
Languages : en
Pages : 416
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Book Description
Despite the fact that the average woman spends one third of her life after the menopause, medical research has been devoted almost entirely to the repro ductive period of her life span. This is perhaps not surprising in our youth orientated society and yet there is increasing evidence that properly applied and supervised hormonal therapy could alleviate many of the severe physical symptoms which are associated with the ovarian menopause and that in the long term other aspects of physical deterioration could be modified. This lack of scientific research has made it difficult to assess which symptoms are due to the altered hormonal status of the post-menopausal period and which are due to the normal process of ageing, or the various psychological pressures which build up around most women in the fourth and fifth decades of life. In America doctors have been treating the 'menopausal syndrome' with estrogens for over 30 years, but in the United Kingdom gynaecologists and family doctors have been reticent to prescribe these steroid preparations. As a consequence, they have been labelled reactionary by the media and while there may be some truth -in this, it should be remembered that the hazar. ds associated with synthetic estrogens in the contraceptive pill were first brought to light by British epidemiological surveys.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309171148
Category : Medical
Languages : en
Pages : 221
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Book Description
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author: Heidi Cullinan
Publisher: Heidi Cullinan
ISBN: 9781945116131
Category : Fiction
Languages : en
Pages :
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Book Description
Know when to show your hand…and when to hedge your bets. Randy Jansen can’t stand to just sit by and watch as a mysterious man throws money away on the roulette wheel, especially since Randy’s got his own bet going as to the reason this guy is making every play like it’s his last day on earth. The man’s dark desperation hits Randy right in the gut. Half of him warns that getting involved is a sucker’s bet, and the other half scrambles for a reason—any reason—to save the man’s soul. Ethan Ellison has no idea what he’s going to do with himself once his last dollar is gone—until Randy whirls into his life with a heart-stealing smile and a poker player’s gaze that sees too much. Randy draws Ethan into a series of wagers that leads to a scorching kiss by midnight, but he isn’t the only one with an interest in Ethan’s vulnerability. Soon they’re both taking risks that not only play fast and loose with the law, but with the biggest prize of all: their hearts.
Author: Ann Aguirre
Publisher: Penguin
ISBN: 9780441016273
Category : Fiction
Languages : en
Pages : 324
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Book Description
Broke and unemployed, "Jumper" Sirantha Jax accepts a diplomatic mission for the government only to find herself up against Syndicate criminals, man-eating aliens, and her own grim, space-weakened body.
Author: Winokur Sara
Publisher:
ISBN: 9781733452809
Category : Fiction
Languages : en
Pages : 318
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Book Description
The International Mystery Double Blind: The Icelandic Manuscript Murders is a wild ride through the cultural landscape of Iceland, from rural farmsteads to icy fjords to the high-tech world of DNA forensics. A young boy disappears in the chill of North Iceland. Twenty years later, a mysterious poem lands on the desk of his twin sister Brynja, a forensic geneticist, and rekindles her hopes that her brother might be alive. As Brynja unravels the clues, more poems arrive, each bearing dire consequences for those who receive them: the guard of the medieval manuscript of Icelandic sagas that may have the answer to her burning question, the prime minister's secretary, the local pastor. Is the poet out to stop Brynja from finding her brother and shut down her access to the DNA database? Or is the verse maker simply a psychopath copycat killer? Fighting the visual auras that have plagued her since childhood and now threaten everything she holds dear, Brynja must summon the strength to navigate the twisted labyrinth of the poet's mind and confront the dark secret buried in her family's past.
Author: Chris Bohjalian
Publisher: Vintage
ISBN: 0307389413
Category : Fiction
Languages : en
Pages : 418
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Book Description
NATIONAL BESTSELLER • From the bestselling author of The Flight Attendant, here is a gripping psychological novel of obsession and consequence. When Laurel Estabrook is attacked while riding her bicycle through Vermont’s back roads, her life is forever changed. Formerly outgoing, Laurel withdraws into her photography, spending all her free time at a homeless shelter. There she meets Bobbie Crocker, a man with a history of mental illness and a box of photographs that he won’t let anyone see. When Bobbie dies, Laurel discovers a deeply hidden secret–a story that leads her far from her old life, and into a cat-and-mouse game with pursuers who claim they want to save her. In a tale that travels between the Roaring Twenties and the twenty-first century, between Jay Gatsby’s Long Island and rural New England, bestselling author Chris Bohjalian has written an extraordinary novel. Look for Chris Bohjalian's new novel, The Lioness!
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309453070
Category : Science
Languages : en
Pages : 487
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Book Description
Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.
