Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease PDF Download
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Author: Lazaros C. Triarhou
Publisher: Springer Science & Business Media
ISBN: 1461506999
Category : Medical
Languages : en
Pages : 152
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Book Description
This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson's disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations.
Author: Lazaros C. Triarhou
Publisher: Springer Science & Business Media
ISBN: 1461506999
Category : Medical
Languages : en
Pages : 152
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Book Description
This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson's disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations.
Author: Lazaros Constantinos Triarhou
Publisher:
ISBN: 9780306474187
Category : Dopaminergic neurons
Languages : en
Pages : 148
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Book Description
"This book is the result of 15 years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse, a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons."--V.
Author: Lazaros Triarhou
Publisher: Springer
ISBN: 9781461507000
Category : Medical
Languages : en
Pages : 148
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Book Description
Author: Leslie L. Iversen
Publisher:
ISBN: 0195373030
Category : Medical
Languages : en
Pages : 632
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Book Description
The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.
Author: Lazaros C. Triarhou
Publisher: Springer Nature
ISBN: 3031130529
Category : Psychology
Languages : en
Pages : 457
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Book Description
The book comprises biographical notes, of about 1000 words each, with a portrait photo, of 90 influential figures of the famous prewar Viennese school of neuropsychiatry, appearing together for the first time in a single volume. The entries focus on the academic lives and scientific contributions of pioneers in the neurological sciences viewed from a modern perspective. These updated profiles are based on substantial new research. The book includes a wide range of people, some famous Nobel laureates, and others less well known, from the era when Vienna was the epicenter of brain research. Despite the tragic circumstances of two World Wars, these pioneers remained resilient, willing to help others with an admirable dignity against adversity that leaves an indelible lesson to the later generations. Some fell victim of the Holocaust. Others overcame the constraints of National Socialism and ultimately settled overseas to nurture their ambitions and pursue their intellectual goals as physicians, researchers, and teachers. The monograph is a useful source for scholars interested in the evolution of ideas in basic neuroscience, clinical neurology, and neuropsychiatry, and the investigators who effected them.
Author: Lazaros C. Triarhou
Publisher: Lulu.com
ISBN: 125715513X
Category : Biography & Autobiography
Languages : en
Pages : 162
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Book Description
Based on original research, this monograph is the first to portray the fascinating life of Bernhard Pollack (1865-1928), a pioneer neurohistologist, ophthalmologist, and world-class pianist. In doing so, it revives important scientists and musicians of fin-du-si cle Berlin. Pollack wrote the first standard reference on the staining methods for the nervous system (1897). Born into a Prussian-Jewish family, he received his piano education from Moritz Moszkowski and his pathology education from Carl Weigert. Pollack worked at the Institutes of W. Waldeyer (anatomy), E. Mendel (neuropsychiatry), Nobel laureate R. Koch (infectious diseases), and the Eye Clinic of P. Silex, before becoming Professor of Ophthalmology at Friedrich-Wilhelms-Universit t in 1919. English translations of two articles by Pollack, on musical memory and on Moszkowski, are included. The book also chronicles the founding by Pollack of the Berliner rzte-Orchester, who in 2011 celebrate their centennial.
Author: Martin Hildebrandt
Publisher: Springer Science & Business Media
ISBN: 0306479206
Category : Medical
Languages : en
Pages : 360
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Book Description
Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.
Author: Lubov T. Timchenko
Publisher: Springer Science & Business Media
ISBN: 1461501172
Category : Medical
Languages : en
Pages : 128
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Book Description
World of Unstable Mutations The book "Triplet Repeat Diseases of the Nervous System" overviews the lat est data on several disorders associated with unstable mutations. This field of re search is progressing extremely fast. The number of polymorphic mutations and diseases caused by these mutations is increasing almost every month. There is a strong interest to molecular bases of triplet repeat disorders. This is explained by growing necessity to develop molecular approaches for cure of these diseases. There fore, the authors of this book describe unstable mutations with the emphasis on molecular pathology. Broad discussion is presented on how polymorphic expan sions cause cell dysfunction. o The first chapter of the book focuses on the molecular pathological pro cesses that originate "unstable" mutations. The authors review several avail able models by which normal "stable" region of DNA become pathogenic and discuss possible mechanisms causing DNA instability. o The other chapters of the book describe inherited diseases associated with different types of unstable mutations. Based on the location of mutation in the disease gene, polymorphic expansions of the nervous system can be divided into two major groups. First group includes disorders with unstable expansions within the open reading frame of the gene such as Spinocer ebellar Ataxias caused by polyglutamine expansions. The second group in cludes diseases caused by expansions situated within the untranslated re gions of the gene.
Author: Zeliha Yazici
Publisher: Springer Science & Business Media
ISBN: 1441991948
Category : Medical
Languages : en
Pages : 240
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Book Description
This volume, the Proceedings of the 12th International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research: Basic Science and Clinical Applications, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid research with special attention to cancer, cardiovascular diseases, gastrointestinal diseases and respiratory diseases. Specific topics covered include the role of leukotrienes and lipoxins in inflammation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
Author: J. Vuyk
Publisher: Springer Science & Business Media
ISBN: 1441991921
Category : Medical
Languages : en
Pages : 279
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Book Description
Since its launch in 1998 the European Society for Intravenous Anaesthesia (EuroSIVA) has come a long way in providing educational material and supporting the research and clinical application of intravenous anaesthesia. After the first two annual meetings held in Barcelona and Amsterdam in 1998 and 1999, three other successful meetings took place in Vienna, Gothenburg and Nice in 2000, 2001 and 2002. Next to these main meetings, starting in the year 2000, a smaller winter meeting has been organised every last week of January in Crans Montana, Switzerland. Both the main summer and the winter meetings breathe the same atmosphere of sharing the latest on intravenous anaesthesia research in the presence of a friendly environment and good company. Since the first meetings the educational tools of EuroSIVA have increased in quantity and technical quality allowing digital slide and video presentation along with the use of the computer simulation program TIVAtrainer during the speaker sessions and the workshops. Furthermore, EuroSIVA now exploits a website www. eurosiva. org that allows for continuous exchange of information on intravenous anaesthesia, the TIVAtrainer, the EuroSIVA meetings and online registration for these meetings. The EuroSIVA is currently engaged in friendly contacts with the Asian Oceanic Society for Intravenous Anaesthesia (AOSIVA), the United Kingdom Society for Intravenous Anaesthesia (UKSIVA), the Korean Society for Intravenous Anaesthesia (KSIVA), the European Society of Anaesthesiology (ESA) and the International Society for Applied Pharmacology (ISAP).
