Studies on DNA Polymerase [beta] PDF Download
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![Studies on DNA Polymerase [beta] PDF](https://books.google.com/books/content/images/frontcover/BWJwHAAACAAJ?fife=w150-h200)
Author: Robin Hsien-wei Chou
Publisher:
ISBN:
Category :
Languages : en
Pages : 141
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![Studies on DNA Polymerase [beta] PDF](https://books.google.com/books/content/images/frontcover/BWJwHAAACAAJ?fife=w80-h100)
Author: Robin Hsien-wei Chou
Publisher:
ISBN:
Category :
Languages : en
Pages : 141
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Author: 林良興
Publisher:
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Category :
Languages : en
Pages :
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Author: Jinwoo Ahn
Publisher:
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Category :
Languages : en
Pages : 210
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Author: Daniela Starcevic
Publisher:
ISBN:
Category :
Languages : en
Pages : 306
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Category : Cell Culture
Languages : en
Pages : 188
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Author: Andrew James Reed
Publisher:
ISBN:
Category : DNA polymerases
Languages : en
Pages : 244
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Adenosine, guanosine, cytidine, and thymidine nucleotides are the building blocks of life and are arranged in distinct combinations to give unique genomic DNA sequences. These DNA encode for all biological molecules and processes and therefore the preservation of genomic integrity is essential for cell growth and viability. To do so the cell has evolved specialized enzymes for efficient and faithful DNA replication. However, genomic DNA is continually damaged by reactive agents occurring from host processes or those encountered through the environment. The resulting DNA damage can act as mutagens causing errors in DNA replication and ultimately leading to disease states or can cause blocks to DNA replication causing replication fork collapse and potentially cell death. To counteract the onslaught of DNA damage cells have evolved a multitude of DNA damage repair mechanisms that can directly revert damaged DNA bases back to the canonical bases, remove and replace single DNA bases (base excision repair), or remove and resynthesize segments of DNA containing damage (nucleotide excision repair and mismatch repair). Base excision repair (BER) in humans is initiated by a damage specific DNA glycosylase that recognizes and removes a single damaged base from DNA, resulting in a product abasic site. This action is followed by cleavage of the abasic site containing DNA strand by apyrimidinic/apurinic endonuclease 1 generating a single-nucleotide gapped DNA substrate with a deoxyribophosphate-aducted 5'-end (5'-dRP). This gap is then filled and the 5'-dRP removed by DNA polymerase ß (Polß) resulting in a nicked DNA substrate. Finally, this nick is ligated by DNA LigaseIII/XRCC1 to complete repair. Here I have investigated the structure and function of Polß to better define its role in DNA repair. Through time-resolved X-ray crystallography and pre-steady-state gel-based kinetics, I have identified and characterized a third divalent metal ion utilized in the synthesis of DNA, determined the mechanism of nucleotide stereoselectivity, and elucidated distinct mechanistic steps following nucleotide incorporation.
![Regulation of DNA Polymerase [beta] by Post-translational Modifications PDF](https://books.google.com/books/content/images/frontcover/aLxJmwEACAAJ?fife=w80-h100)
Author: Nazim El-Andaloussi
Publisher:
ISBN:
Category :
Languages : en
Pages : 87
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Author: Giovanni Maga
Publisher: World Scientific
ISBN: 9813226420
Category : Science
Languages : en
Pages : 398
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Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.
Author: Danah Almohdar
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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filling activity when compared to wild-type.
Author: Subarna Hamid
Publisher:
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Category :
Languages : en
Pages :
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