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Author: Philipp Kaldis
Publisher: Results and Problems in Cell Differentiation
ISBN:
Category : Medical
Languages : en
Pages : 400
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Book Description
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Author: Philipp Kaldis
Publisher: Results and Problems in Cell Differentiation
ISBN:
Category : Medical
Languages : en
Pages : 400
Get Book Here
Book Description
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Critical predictions as to the biological behavior, and thus the appropriate therapeutic strategy, of breast cancers can be made based upon the status of the estrogen receptor (ER). In support of DOD grant # DAMD-17-97-1-7069, our goal is to better understand the mechanisms by which ER controls the expression of target genes and therefore mediates the biological effects upon gene regulation and cell cycle progression. Our detailed studies of the regions of ER that control cell cycle progression in breast cancer cell lines have indicated an absolute requirement for the Activating Function-2 (AF-2) region of ER for hormone-dependent cell cycle progression. In many different classes of nuclear receptors, this area has been vigorously studied and has been shown to be important for the physical interaction between hormone bound receptors and coactivators. Our studies have demonstrated that mechanisms involving the chemical and structural modification of chromatin are critical for transcriptional responses to estrogen and may also be important for estrogen-dependent cell cycle progression.
Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 516
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Book Description
Author: Helge Großhans
Publisher: Springer
ISBN: 9781441978240
Category : Science
Languages : en
Pages : 160
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Book Description
Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.
Author: Juliusz Ashot Kozak
Publisher: CRC Press
ISBN: 149875273X
Category : Science
Languages : en
Pages : 343
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Book Description
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1860
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Book Description
Author: Sohaib A. Khan
Publisher: CRC Press
ISBN: 9780849386725
Category : Medical
Languages : en
Pages : 298
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Book Description
Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation reviews current information regarding the complex nature of hormone-induced cell growth and differentiation. The contributors examine the emerging consensus that protooncogenes and growth factors mediate perhaps the most crucial steps leading to cell growth and differentiation. The primary objective of this book is to unite the status of current research related to protooncogenes and growth factors from diverse physiological systems to help readers gain a comprehensive understanding of the subject. Leading researchers have contributed outstanding chapters pertaining to steroid hormone-regulated cell growth and differentiation in normal and/or neoplastic tissues. This book will appeal to basic science researchers, clinicians, industrial researchers, and graduate students.
Author: Derek Leroith
Publisher: Springer Science & Business Media
ISBN: 9780306478468
Category : Medical
Languages : en
Pages : 524
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Book Description
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 2520
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Raimo Pohjanvirta
Publisher: John Wiley & Sons
ISBN: 1118140567
Category : Science
Languages : en
Pages : 858
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Book Description
This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.
