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Author: Alexandre A. Shvartsburg
Publisher: CRC Press
ISBN: 9781420051070
Category : Science
Languages : en
Pages : 322
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Book Description
Over the last decade, scientific and engineering interests have been shifting from conventional ion mobility spectrometry (IMS) to field asymmetric waveform ion mobility spectrometry (FAIMS). Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS explores this new analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of dipole direction. The book relates the fundamentals of FAIMS and other nonlinear IMS methods to the physics of gas-phase ion transport. It begins with the basics of ion diffusion and mobility in gases, covering the main attributes of conventional IMS that are relevant to all IMS approaches. Building on this foundation, the author reviews diverse high-field transport phenomena that underlie differential IMS. He discusses the conceptual implementation and first-principles optimization of FAIMS as a filtering technique, emphasizing the dependence of FAIMS performance metrics on instrumental parameters and properties of ion species. He also explores ion reactions in FAIMS caused by field heating and the effects of inhomogeneous electric field in curved FAIMS gaps. Written by an accomplished scientist in the field, this state-of-the-art book supplies the foundation to understand the new technology of nonlinear IMS methods.
Author: Alexandre A. Shvartsburg
Publisher: CRC Press
ISBN: 9781420051070
Category : Science
Languages : en
Pages : 322
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Book Description
Over the last decade, scientific and engineering interests have been shifting from conventional ion mobility spectrometry (IMS) to field asymmetric waveform ion mobility spectrometry (FAIMS). Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS explores this new analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of dipole direction. The book relates the fundamentals of FAIMS and other nonlinear IMS methods to the physics of gas-phase ion transport. It begins with the basics of ion diffusion and mobility in gases, covering the main attributes of conventional IMS that are relevant to all IMS approaches. Building on this foundation, the author reviews diverse high-field transport phenomena that underlie differential IMS. He discusses the conceptual implementation and first-principles optimization of FAIMS as a filtering technique, emphasizing the dependence of FAIMS performance metrics on instrumental parameters and properties of ion species. He also explores ion reactions in FAIMS caused by field heating and the effects of inhomogeneous electric field in curved FAIMS gaps. Written by an accomplished scientist in the field, this state-of-the-art book supplies the foundation to understand the new technology of nonlinear IMS methods.
Author: ALEXANDRE A. SHVARTSBURG
Publisher: CRC Press
ISBN: 9780367577377
Category :
Languages : en
Pages : 322
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Book Description
One of the first books available on this topic of emerging interest, this text explores a new analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of di
Author: G.A. Eiceman
Publisher: CRC Press
ISBN: 1439859981
Category : Science
Languages : en
Pages : 418
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Book Description
Since the turn of the twenty-first century, applications of ion mobility spectrometry (IMS) have diversified, expanding their utility in the military and security spheres and entering the realms of clinical practice and pharmaceutical exploration. Updated and expanded, the third edition of Ion Mobility Spectrometry begins with a comprehensive discu
Author: G.A. Eiceman
Publisher: CRC Press
ISBN: 1420038974
Category : Science
Languages : en
Pages : 367
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Book Description
Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for the rapid and advanced detection of explosives, chemical and biological warfare agents, and narcotics, ion mobility spectrometry (IMS) undergone significant refinements in technology, computational capabilities, and understanding of the principles of gas phase
Author: Charles L. Wilkins
Publisher: CRC Press
ISBN: 1439813256
Category : House & Home
Languages : en
Pages : 374
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Book Description
The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved w
Author: Frank Sobott
Publisher: Royal Society of Chemistry
ISBN: 1839161663
Category : Science
Languages : en
Pages : 547
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Book Description
Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and will help the end users understand the practicalities of using different instruments for different ion mobility purposes.
Author: Marlen R. Menlyadiev
Publisher:
ISBN:
Category : Ion mobility spectroscopy
Languages : en
Pages : 196
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Book Description
Ion mobility spectrometry (IMS) provides knowledge of the ions shape and size through the measurement of the speed of ion swarms derived from a substance in electric fields. In one embodiment of IMS, termed differential mobility spectrometry (DMS), ions are characterized and separated through differences in mobilities at high and low electric fields. DMS analyzers exhibit poor resolution between peaks for ions masses from 150 to 300 Da. An advantage of small, planar DMS drift tubes operating in air at ambient pressure, however, is a continuous duty cycle for ion transmission, making DMS an ion filter. This feature favors the development of DMS analyzers in tandem configurations to improve peak capacity or selectivity of response in the current practice of DMS. Mobility measurements with independent control of ion motion in two sequential stages of DMS drift tube were achieved in a first demonstration of tandem DMS. Combinations of separation and compensation fields at characteristic or specific pairs for two DMS stages were used to isolate individual subtances from others in the mixture of volatile organic compounds using based field dependent mobilities of ions in DMS. The selectivity of the measurement expressed as the ratio of analyte signal over the sum of signals of twenty two interfering compunds was improved 31X for dimethyl methylphosphonate and 106X for 1-hexanol in a tandem DMS measurement. Chemical modification of proton-bound dimers of dimethyl methphosphonate and tributyl phosphate in tandem DMS was achived using vapors of isopropanol introduced to the supporting atmosphere after ion selection in a first stage. Ions isolated near 0 Townsend in a compensation field in a firsrt DMS stage underwent displacement reactions under the influence of vapor modifier which resulted in increased peak capacity. Finally, proton-bound dimers were dissociated through electric field heating of ions into protonated monomer ions in air at ambient pressure at 25° C using a tandem DMS instrument where the first stage was an ultrahigh field asymmetric waveform ion mobility spectrometer (ultraFAIMS). Protonated monomers were measured in a second stage from dissociation of proton-bound dimer ions of acetone, ethyl acetate, and dimethyl methylphosphonate. Fragment ions were formed from propyl acetate by heating proton-bound dimer ions at 90 Td. This provides a route to improve peak capacity in DMS without gas modifiers. An additional advantage of tandem DMS with fixed pairs of compensation and separation fields should be higher (~10 ms) speed of response. These achievments establish a foundation for triple stage DMS with ion pre-selection, fragmentation, and characterization as an ambient pressure analog to tandem mass spectrometry.
Author: Richard A. Crocombe
Publisher: John Wiley & Sons
ISBN: 1119636434
Category : Science
Languages : en
Pages : 608
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Book Description
The most comprehensive resource available on the many applications of portable spectrometers, including material not found in any other published work Portable Spectroscopy and Spectrometry: Volume Two is an authoritative and up-to-date compendium of the diverse applications for portable spectrometers across numerous disciplines. Whereas Volume One focuses on the specific technologies of the portable spectrometers themselves, Volume Two explores the use of portable instruments in wide range of fields, including pharmaceutical development, clinical research, food analysis, forensic science, geology, astrobiology, cultural heritage and archaeology. Volume Two features contributions by a multidisciplinary team of experts with hands-on experience using portable instruments in their respective areas of expertise. Organized both by instrumentation type and by scientific or technical discipline, 21 detailed chapters cover various applications of portable ion mobility spectrometry (IMS), infrared and near-infrared (NIR) spectroscopy, Raman and x-ray fluorescence (XRF) spectroscopy, smartphone spectroscopy, and many others. Filling a significant gap in literature on the subject, the second volume of Portable Spectroscopy and Spectrometry: Features a significant amount of content published for the first time, or not available in existing literature Brings together work by authors with assorted backgrounds and fields of study Discusses the central role of applications in portable instrument development Covers the algorithms, calibrations, and libraries that are of critical importance to successful applications of portable instruments Includes chapters on portable spectroscopy applications in areas such as the military, agriculture and feed, hazardous materials (HazMat), art conservation, and environmental science Portable Spectroscopy and Spectrometry: Volume Two is an indispensable resource for developers of portable instruments in universities, research institutes, instrument companies, civilian and government purchasers, trainers, operators of portable instruments, and educators and students in portable spectroscopy courses.
Author:
Publisher: Elsevier
ISBN: 0444641556
Category : Science
Languages : en
Pages : 278
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Book Description
Ion Mobility Spectrometry, Volume 83 will focuses on new trends, methods and instrumentation in the field, starting from the innovations of each technique, to the most progressive challenges of IM-MS. Chapters includes section on Recent advances in IM-MS, IM-MS Principles and Theory, IM-MS Applications and Instrumentation, and the Future of IM-MS. Presents the latest advancements in IM-MS that are essential for new applications Helps readers understand the state-of-the-art in the currently available IM-MS interfaces and their principle uses Provides information on different IM-MS instrumentation Delves into key applications of IM-MS
Author: Kenneth W. Busch
Publisher: Elsevier
ISBN: 0080469280
Category : Science
Languages : en
Pages : 721
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Book Description
Chiral Analysis covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals. The target audience is scientific professionals with an undergraduate background in chemistry or a related discipline, specifically organic chemists, researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries, and graduate students in chemistry. Chapters have been written with the nonspecialist in mind so as to be self-contained. * Broad coverage - spectroscopic and separation methods covered in a single volume * Up-to-date and detailed review of the various techniques available and/or under development in this field * Contributions from leading experts in the field
