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Author: Martin J. Stoddart
Publisher: Academic Press
ISBN: 0128115386
Category : Science
Languages : en
Pages : 270
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Book Description
Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair
Author: Martin J. Stoddart
Publisher: Academic Press
ISBN: 0128115386
Category : Science
Languages : en
Pages : 270
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Book Description
Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair
Author: Justin Brown
Publisher: Academic Press
ISBN: 0128033991
Category : Technology & Engineering
Languages : en
Pages : 254
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Book Description
Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations. The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications. In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics. Presents a self-contained work for the field of musculoskeletal tissue engineering and regenerative medicine Focuses on how materials of structures can be designed to be resistant while promoting viable grafts Contains major tissue types that are covered with a strategy for each material and structure
Author: Huinan H. Liu
Publisher: Woodhead Publishing
ISBN: 178242475X
Category : Technology & Engineering
Languages : en
Pages : 408
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Book Description
Nanocomposites for Musculoskeletal Tissue Regeneration discusses the advanced biomaterials scientists are exploring for use as tools to mimic the structure of musculoskeletal tissues. Bone and other musculoskeletal tissues naturally have a nanocomposite structure, therefore nanocomposites are ideally suited as a material for replacing and regenerating these natural tissues. In addition, biological properties such as biointegration and the ability to tailor and dope the materials make them highly desirable for musculoskeletal tissue regeneration. Provides a comprehensive discussion on the design and advancements made in the use of nanocomposites for musculoskeletal tissue regeneration Presents an In-depth coverage of material properties Includes discussions on polymers, ceramics, and glass
Author: Yupeng Chen
Publisher: Elsevier
ISBN: 0128242108
Category : Technology & Engineering
Languages : en
Pages : 385
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Book Description
Musculoskeletal Tissue Engineering introduces the fundamental concepts and translational applications of musculoskeletal tissue engineering, in combination with emerging technologies and materials. Sections discuss Tissues and Technologies, covering a range of musculoskeletal tissues, including bone, cartilage, ligament and more. Each chapter in this section details core tissue engineering principles specific to each tissue type. Next, a Technologies section looks at the range of biomaterials used in musculoskeletal tissue engineering, focusing on biocompatibility of materials and interactions at the material-tissue interface. Other chapters cover nanotechnology, 3D printing, gene therapy, tissue chips, and more. This book offers an advanced reference text for researchers in biomedical engineering, materials science and regenerative medicine. Details various materials and cutting-edge technologies for musculoskeletal tissue engineering Covers a range of musculoskeletal tissues, including bone, cartilage, ligament, tendon, meniscus, and more Provides a balance between basic concepts and translational applications for a broad audience
Author: Syam Nukavarapu
Publisher: Woodhead Publishing
ISBN: 1782423141
Category : Science
Languages : en
Pages : 463
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Book Description
Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces. Comprehensive review of the repair and regeneration of musculoskeletal individual tissues and tissue interfaces Presents recent developments, fundamentals and progress in the field of engineering tissues Reviews progress and advances in tissue vascularization and innervation
Author: Robert Lanza
Publisher: Academic Press
ISBN: 0080548849
Category : Science
Languages : en
Pages : 1344
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Book Description
First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike. New to this edition:*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems
Author: Manuela E. Gomes
Publisher: Elsevier
ISBN: 0443134308
Category : Science
Languages : en
Pages : 0
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Book Description
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes was the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective field’s present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.New coverage will include signaling pathways for tendon development, molecular mechanisms of tendinopathy, inflammation contribution to healing and pathology of tendons, tendon aging and degeneration, tendon models, and translational studies for tendon regenerative medicine. Provides an updated overview of tendon biology, disease, and tissue engineering approaches Presents new subjects, namely experimental models and translational chapters not included in the first edition, due to limited literature on tendon regeneration Written by renowned scientists, engineers, and clinicians from around the world
Author: Ajaykumar Vishwakarma
Publisher: Academic Press
ISBN: 0123977789
Category : Technology & Engineering
Languages : en
Pages : 933
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Book Description
Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color
Author: William S. Pietrzak
Publisher: Springer Science & Business Media
ISBN: 1597452394
Category : Medical
Languages : en
Pages : 647
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Book Description
The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.
Author: Mehdi Razavi
Publisher: Academic Press
ISBN: 0128202637
Category : Science
Languages : en
Pages : 290
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Book Description
Nanoengineering in Musculoskeletal Regeneration provides the reader an updated summary of the therapeutic pipeline—from biomedical discovery to clinical implementation—aimed at improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus, and bone. Regenerative medicine focuses on using stem cell biology to advance medical therapies for devastating disorders. This text presents novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in musculoskeletal regeneration. Content includes basic, translational, and clinical research addressing musculoskeletal repair and regeneration for the treatment of diseases and injuries of the skeleton and its associated tissues. Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Additionally, defects in skeletal tissues may immobilize people and cause inflammation and pain. Musculoskeletal regeneration research provides solutions to repair, restore, or replace skeletal elements and associated tissues that are affected by acute injury, chronic degeneration, genetic dysfunction, and cancer-related defects. The goal of musculoskeletal regeneration medicine research is to improve quality of life and outcomes for people with musculoskeletal injury or degradation. Provides broad coverage in all research areas focused on the applications of nanotechnology in musculoskeletal regeneration Offers useful guidance for physician-scientists with expertise in orthopedics, regenerative medicine, bioengineering, biomaterials, nanoengineering, stem cell biology, and chemistry Serves as a practical reference for many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, musculoskeletal regenerative medicine, and nanomedicine
