Development, Application and Characterization of a Single Cell Based Sensor PDF Download
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Author: Shalini Prasad
Publisher:
ISBN:
Category : Biosensors
Languages : en
Pages : 450
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Book Description
Author: Shalini Prasad
Publisher:
ISBN:
Category : Biosensors
Languages : en
Pages : 450
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Book Description
Author: Jian Chen
Publisher: Elsevier
ISBN: 0323898416
Category : Science
Languages : en
Pages : 182
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Book Description
Biosensors for Single-Cell Analysis explores a wide range of biosensor technologies and their applications in single-cell characterization and analysis. Sections cover key biophysical and chemical single-cell properties that consider proteomic, metabolic, electrical, mechanical and optical properties. Each chapter features key definitions and case studies, providing detailed guidance for researchers who want to replicate covered solutions in their work. Tutorial sections, evaluations of the current state-of-the-field and future developments are also included. Microfluidic approaches to characterization, such as microfluidic impedance flow cytometry and microfluidic flow cytometry are considered alongside more conventional approaches, such as mass spectroscopy, fluorescent and mass flow cytometry. Additionally, key types of biosensors are covered, including atomic force microscopy, micropipette aspiration, optical tweezers, microfluidic hydrodynamic stretchers, microfluidic constriction channel and microfluidic optical stretchers. Includes chapters focused on key single-cell properties, such as proteomic, metabolic and mechanical characterization Features case studies that illustrate the application of biosensors for single-cell analysis Considers microfluidic approaches for each single-cell property discussed Explores future directions for single-cell analysis and biosensor technology
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 850
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Book Description
Author: Wenyang Jing
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Qingjun Liu
Publisher: Artech House
ISBN: 1596934409
Category : Medical
Languages : en
Pages : 291
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Book Description
Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
Author: Maximilian Oberleitner
Publisher: Springer
ISBN: 331945384X
Category : Science
Languages : en
Pages : 391
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Book Description
This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.
Author: Toi Vo Van
Publisher: Springer
ISBN: 9811043612
Category : Technology & Engineering
Languages : en
Pages : 873
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Book Description
Under the motto “Healthcare Technology for Developing Countries” this book publishes many topics which are crucial for the health care systems in upcoming countries. The topics include Cyber Medical Systems Medical Instrumentation Nanomedicine and Drug Delivery Systems Public Health Entrepreneurship This proceedings volume offers the scientific results of the 6th International Conference on the Development of Biomedical Engineering in Vietnam, held in June 2016 at Ho Chi Minh City.
Author: Larisa Lvova
Publisher: Frontiers Media SA
ISBN: 2889457214
Category :
Languages : en
Pages : 175
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Book Description
Nowadays the application of multisensor systems for the analysis of liquids and gases is becoming more and more popular in analytical chemistry. Such systems, also known as “electronic tongues” and “electronic noses” are based on various types of chemical sensors and biosensors with different transduction principles combined with multivariate data processing protocols. These instruments received significant interest due to their simplicity, low costs and the possibility to obtain reliable chemical information from complex unresolved analytical signals. A distinct feature of electronic tongues and noses is that they can be calibrated for prediction of complex integral features in samples, like e.g. taste, odor, toxicity, geographical origin, general conformity with certain standards, etc. – the tasks that otherwise would require involvement of complex analytical instrumentation, human or animal sensory panels. In the present eBook the original research and review articles in the area of multisensor approach are collected. They dedicated to the novel sensor materials development, measuring techniques evaluation, electronics, data processing protocols and practical applications. An editorial foreword article is followed by the researches authored by leading scientists in the field of chemical sensors and artificial sensing systems. With this eBook we hope to inspire further interest and new research efforts in this exciting area.
Author: James A. Schwarz
Publisher: CRC Press
ISBN: 9780824750503
Category : Science
Languages : en
Pages : 722
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Book Description
Author: Francisco Feijó Delgado
Publisher:
ISBN:
Category :
Languages : en
Pages : 128
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Book Description
The physical properties of a cell are manifestations of its most basic molecular and metabolic processes. In particular, size has been a sought metric, which can be difficult to ascertain with great resolution or for smaller organisms. The advancement of single-cell measurement techniques and the understanding of cell-to-cell variability have renewed the interest in size characterization. In addition, knowledge of how individual cells grow and coordinate their growth with the cell cycle is of fundamental interest to understanding cell development, but various approaches for describing cellular growth patterns have often reached irreconcilable conclusions. In this thesis, a highly sensitive microfabricated single-cell mass sensor - the suspended microchannel resonator - is used to demonstrate cellular growth measurements by mass accumulation for several microorganism, ranging from bacterial cells to eukaryotes and mammalian cells. From those measurements insights about cellular growth are derived, demonstrating that larger cells grow faster than smaller ones, consistent with exponential-like growth patterns and incompatible with linear growth models. Subsequently, the implementation of mechanical traps as means to optimize existing sensors is presented and the techniques are applied to the measurement of total mass, density and volume at the single-cell level. Finally, a method is introduced to quantify cellular dry mass, dry density and water content. It is based on weighing the same cell first in a water-based fluid and subsequently in a deuterium oxide-based fluid, which rapidly exchanges the intracellular water content. Correlations between dry density and cellular proliferation and composition are described. Dry density is described as a quantitative index that correlates with proliferation and cellular chemical composition.
