Design, Synthesis and Biological Evaluation of Novel Cyclin-dependent Kinase 9 Inhibitors as Anticancer Agents PDF Download
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Author: Hamad Musfer Alkhtani
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 470
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Book Description
Author: Hamad Musfer Alkhtani
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 470
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Book Description
Author: Qiao-Hong Chen
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
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Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Author: Xianrui Zhao
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Jin Chen
Publisher:
ISBN: 9781109967388
Category : Antineoplastic agents
Languages : en
Pages : 373
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Book Description
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Author: Larisa Kuznetsova
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 584
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Hao Shao
Publisher:
ISBN:
Category : Cyclin-dependent kinases
Languages : en
Pages : 0
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Author: Jude E. Mathews
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
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Author: Samukelisiwe Pretty Khathi
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 314
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Author: Nicola Dione Henderson
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 0
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