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Author: Junzhe Lou
Publisher:
ISBN:
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Languages : en
Pages :
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Book Description
Rational design of hydrogels and charged polymers is important for understanding the underlying principles that govern complex mechanical and phase behaviors of biomacromolecular systems. Mimicking and capturing such behaviors in synthetic polymer systems are highly desired for many biomedical and technical applications. Biological tissues exhibit complex dynamic mechanical properties. To capture and control dynamics in synthetic hydrogel scaffolds, I developed a hyaluronic acid (HA)-based dynamic hydrogel system crosslinked by dynamic covalent hydrazone bonds. The HA hydrogels and collagen I generated an interpenetrating network, which exhibited both well-controlled mechanical tunability and fibrillarity, thus providing an adaptable platform to study the cell-matrix interactions. A biocompatible catalyst that accelerates the exchange of hydrazones was then incorporated into the HA-hydrazone hydrogel to modulate the dynamics of crosslinks without affecting network structures. This approach was used to develop injectable hydrogels for cell delivery with high injectability and stability enabled by temporal catalyst controlled hydrogel dynamics. The catalyst control of network dynamics also enabled quantitative and unambiguous correlation between the network parameters and mechanical properties of dynamic polymer networks. In the second part, I investigated the fundamental study on liquid-like polyelectrolyte complexes (PECs) formed by oppositely charged polyelectrolytes. PECs are important in biological systems for membraneless compartments, however the understanding of the mechanism and structure-property relationship is limited. I developed a series of well-defined polymers with tunable structural parameters to modulate the microenvironment of PECs and clearly revealed the importance of local polarity and polyelectrolyte composition on PECs.
Author: Junzhe Lou
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Rational design of hydrogels and charged polymers is important for understanding the underlying principles that govern complex mechanical and phase behaviors of biomacromolecular systems. Mimicking and capturing such behaviors in synthetic polymer systems are highly desired for many biomedical and technical applications. Biological tissues exhibit complex dynamic mechanical properties. To capture and control dynamics in synthetic hydrogel scaffolds, I developed a hyaluronic acid (HA)-based dynamic hydrogel system crosslinked by dynamic covalent hydrazone bonds. The HA hydrogels and collagen I generated an interpenetrating network, which exhibited both well-controlled mechanical tunability and fibrillarity, thus providing an adaptable platform to study the cell-matrix interactions. A biocompatible catalyst that accelerates the exchange of hydrazones was then incorporated into the HA-hydrazone hydrogel to modulate the dynamics of crosslinks without affecting network structures. This approach was used to develop injectable hydrogels for cell delivery with high injectability and stability enabled by temporal catalyst controlled hydrogel dynamics. The catalyst control of network dynamics also enabled quantitative and unambiguous correlation between the network parameters and mechanical properties of dynamic polymer networks. In the second part, I investigated the fundamental study on liquid-like polyelectrolyte complexes (PECs) formed by oppositely charged polyelectrolytes. PECs are important in biological systems for membraneless compartments, however the understanding of the mechanism and structure-property relationship is limited. I developed a series of well-defined polymers with tunable structural parameters to modulate the microenvironment of PECs and clearly revealed the importance of local polarity and polyelectrolyte composition on PECs.
Author: Eric Allen Alt
Publisher:
ISBN:
Category :
Languages : en
Pages : 131
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Book Description
Polymer network based gels are an important class of materials with a wide range of applications. Dynamic polymer networks, which crosslink via the formation of reversible bonds, in particular have great potential as stimuli responsive, mechanically tunable, and self-healing materials. Many important emergent properties of these materials, such as mechanical strength, are mediated by their underlying network structure, which can be characterized by the network topology and spatial distribution of nodes. Therefore, unlocking the full potential of these materials through rational design requires an understanding of how network structure arises as a function of network-forming precursor design. Because the bonds that crosslink dynamic polymer networks are reversible, stresses initially present or otherwise induced in these systems can be relieved through network rearrangement. As such, given sufficient time to relax, the network structure is determined by equilibrium thermodynamics. This work presents a thermodynamic formalism which characterizes the free energy of a network in terms of node positional, network topological, and polymer conformational entropies. Through this lens, and aided by numerical calculations and simulations of model networks, we show how the free energy landscape with respect to density relates to factors which can be readily controlled through precursor design, such as polymer length and node size. Additionally, Monte Carlo simulations of explicit networks reveal that thermodynamic relaxation can give rise to spatial heterogeneity in the arrangement of network nodes. In the last chapter we use the tools developed in the earlier chapters to explore how these same design parameters influence the topological statistics of equilibrium networks. In addition to showing how internode connectivity increases with polymer length and system density, we find that inhomogeneity due to spatial relaxation can also lead to greater network connectivity. Finally, we explore the weakening of network topologies due to substitution of polymer-linked node forming components with topologically non-functional counterparts, finding that larger nodes fare better than their smaller counterparts in maintaining network connectivity when these substitutions are made.
Author: Nobuhiko Yui
Publisher: CRC Press
ISBN: 0203485351
Category : Medical
Languages : en
Pages : 469
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Book Description
. Despite their capacity to carry out functions that previously were unobtainable, smart polymers and hydrogels tend to have painfully slow response times. On the other hand biological systems go through phase changes at an extremely fast rate. Reflexive Polymers and Hydrogels examines the natural systems that respond almost instantaneously to envi
Author: Christopher Brittain Cooper
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Many emerging applications including wearable electronics and e-skins, soft robotics and actuators, and biomaterials, require material platforms with precisely controlled mechanical, electrical, thermal, and optical properties. The practical realization of devices for these applications is often restricted not by the lack of novel designs, but rather by the sparsity of materials with the required properties. Dynamic polymers, which employ both permanent and reversible linkages, offer a promising platform for the design of new materials due to their highly tunable and responsive chemical structures. This dissertation explores structure-property relationships in different dynamic polymer networks with well-defined polymer design and is structured as follows. Chapter 1 introduces the concept of dynamic polymers, provides comparisons to supramolecular polymers and segmented block copolymers, and concludes with emerging applications for these systems. Chapter 2 examines the molecular design rules for spontaneous self-assembly of periodic dynamic polymers into supramolecular nanofibers. Chapter 3 discusses the phenomenon of strain-induced supramolecular structures exhibited by entangled periodic dynamic polymers. Chapter 4 highlights how the clustered nanomorphology exhibited by periodic dynamic polymers can be used to design recyclable underwater adhesives. Chapter 5 explains how immiscible dynamic polymers can be used to achieve autonomous alignment of multilayered soft electronics. Chapter 6 concludes with key observations and on the future outlook of next-generation materials.
Author: Tsetska Radeva
Publisher: CRC Press
ISBN: 1482270684
Category : Science
Languages : en
Pages : 936
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Book Description
An examination of the fundamental nature of polyelectrolytes, static and dynamic properties of salt-free and salt-added solutions, and interactions with other charged and neutral species at interfaces with applications to industry and medicine. It applies the Metropolis Monte Carlo simulation to calculate counterion distributions, electric potentia
Author: Martin Müller
Publisher: Springer
ISBN: 3642407463
Category : Technology & Engineering
Languages : en
Pages : 269
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Book Description
Polyelectrolyte Complexes for Tailoring of Wood Fibre Surfaces. Polyelectrolyte Complexes in Flocculation Applications. Spontaneous Assembly and Induced Aggregation of Food Proteins. Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors. Sizing, Shaping and Pharmaceutical Applications of Polyelectrolyte Complex Nanoparticles.
Author: Visakh P. M.
Publisher: Springer
ISBN: 3319016806
Category : Technology & Engineering
Languages : en
Pages : 388
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Book Description
This book offers a valuable reference source to graduate and post graduate students, engineering students, research scholars polymer engineers from industry. The book provides the reader with current developments of theoretical models describing the thermodynamics polyelectrolytes as well as experimental findings. A particular emphasis is put on the rheological description of polyelectrolyte solutions and hydrogels.
Author: Manfred Schmidt
Publisher: Springer Science & Business Media
ISBN: 9783540005285
Category : Technology & Engineering
Languages : en
Pages : 284
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Book Description
Praise for Ed M.Schmidt's, Polyelectrolytes with Defined Molecular Architecture I POLYMERNEWS "All articles are well prepared and structured. Although not written as textbooks, general introductions of the chapters provide basic knowledge of the separate fields, methods and theoretical background. Therefore, the volumes can be recommended not only for specialists in the field. The books make an important contribution to polyelectrolyte research and application. I recommend the volumes to all scientists and engineers actively dealing with polyelectrolytes."
Author:
Publisher:
ISBN: 9789464583014
Category :
Languages : en
Pages : 119
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Book Description
Author: Martin Müller
Publisher: Springer
ISBN: 9783662509029
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
Advances in Polymer Science enjoys a longstanding tradition and good reputation in its community. Each volume is dedicated to a current topic, and each review critically surveys one aspect of that topic, to place it within the context of the volume. The volumes typically summarize the significant developments of the last 5 to 10 years and discuss them critically, presenting selected examples, explaining and illustrating the important principles, and bringing together many important references of primary literature. On that basis, future research directions in the area can be discussed. Advances in Polymer Science volumes thus are important references for every polymer scientist, as well as for other scientists interested in polymer science - as an introduction to a neighboring field, or as a compilation of detailed information for the specialist.
