Design and Optimization of Microwave Ablation Tools and Techniques PDF Download
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Languages : en
Pages : 0
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Thermal ablation is a minimally-invasive procedure that is used as an alternative to surgical resection in treating early-stage solid tumors. Due to its percutaneous route of administration, thermal ablations have been shown to be associated with less bleeding, fewer complications and quicker recovery compared to surgery. While radiofrequency ablation (RFA) is currently the most common heating modality used for ablation, microwave ablations have rapidly gained traction in academic centers in recent years due to its improved heating physics. Microwave offers substantial benefits over radiofrequency ablation through faster heat generation, leading to larger and more homogenous ablation zones in highly-perfused tissue. These qualities can lead to better margins during tumor ablation and a smaller chance for tumor recurrence. However, controlling the high power and temperatures associated with microwave has remained a formidable barrier toward widespread clinical adoption. The tools used in microwave ablation, especially the antenna itself, require modifications in order to decrease shaft heating. The physics of microwave heating, which now incorporate water vaporization, needs to be accounted for in the tissue heating process. Lastly, the role of hotter ablation zones in thrombosing larger blood vessels is becoming a growing concern for physicians. This thesis aims to further our understanding of these issues.
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Languages : en
Pages : 0
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Book Description
Thermal ablation is a minimally-invasive procedure that is used as an alternative to surgical resection in treating early-stage solid tumors. Due to its percutaneous route of administration, thermal ablations have been shown to be associated with less bleeding, fewer complications and quicker recovery compared to surgery. While radiofrequency ablation (RFA) is currently the most common heating modality used for ablation, microwave ablations have rapidly gained traction in academic centers in recent years due to its improved heating physics. Microwave offers substantial benefits over radiofrequency ablation through faster heat generation, leading to larger and more homogenous ablation zones in highly-perfused tissue. These qualities can lead to better margins during tumor ablation and a smaller chance for tumor recurrence. However, controlling the high power and temperatures associated with microwave has remained a formidable barrier toward widespread clinical adoption. The tools used in microwave ablation, especially the antenna itself, require modifications in order to decrease shaft heating. The physics of microwave heating, which now incorporate water vaporization, needs to be accounted for in the tissue heating process. Lastly, the role of hotter ablation zones in thrombosing larger blood vessels is becoming a growing concern for physicians. This thesis aims to further our understanding of these issues.
Author: Punit Prakash
Publisher:
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Category :
Languages : en
Pages : 164
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Author: Sevde Etoz Niemeier
Publisher:
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Category :
Languages : en
Pages : 0
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Microwave ablation is one of the most common minimally invasive targeted cancer treatment technique. Since development phase of the technique resulted in several commercial ablation systems, current research topics include optimization of the current systems and practices. Recent studies have shown that outcomes of microwave ablation can vary patient to patient. To foresee the ablation results, investigation of treatment planning techniques has gained great interest recently. Simulations have been the main tool for the treatment planning process which requires accurate tissue models. In this work, I investigated new simulation approaches to increase microwave ablation simulation accuracy. Chapter 1 provides an introduction to the current state of microwave ablation and the variability of ablation outcomes with the current systems are presented. Potential sources of this variability were discussed. Moreover, the accuracy of microwave ablation simulations was evaluated with ex-vivo studies (experiments and simulations). The study results suggested that current dielectric property models need improvement. Therefore, following chapters focused on the dielectric tissue property model development for liver and lung tissues. In microwave ablation context, tissue properties can be divided into two groups: baseline and temperature dependent temporal changes during heating. Both depends on the constituents of tissues; therefore, dielectric mixture models were used in the development of liver and lung tissue models. Chapter 2 presents tissue models which were tissue water content dependent. It has been assumed that water content was responsible for the drastic changes in dielectric properties during heating. Chapter 3 outlines the techniques for application of the water content dependent dielectric mixture models in the microwave ablation setting. With this study, it was directly shown that vaporization was the most dominant mechanism in dielectric property change at high temperatures, dielectric mixture models can model vapor induced effects, and the proposed approach with the mixture model allowed more accurate dielectric property predictions than the current models in literature. Since this study focused the temporal changes of tissue properties. In the first 3 chapters, temporal changes in dielectric properties were studied. Chapter 4 presents experiments and simulations in phantoms for tissues with ectopic fat storage, which changes the baseline tissue properties. Differences in heating mechanisms in phantoms with varying fat contents were discovered. Moreover, a framework was introduced for imaging-based (magnetic resonance imaging) determination of baseline tissue dielectric properties. Chapter 5 describes lung tissue dielectric property models that have been built with the data that was collected. The aim of this study was to develop an air content tissue model for lung, therefore, concurrent measurements of dielectric properties with open-ended coaxial probe and air content with CT and microCT was included in the model development process. Chapter 6 describes the implementation of the tissue dielectric property model that was developed in the Chapter 2 and 3 in simulations. The results of the simulated ablation zones were compared with the ablation zones that were measured precisely by accounting for the contraction. The simulations with the proposed model had higher accuracy in the prediction of the ablation zone dimensions in ex-vivo tissues. Chapter 6 also included a study on thermal behavior of the liver perfusion. The literature review on perfusion in the thermal ablation area showed the need for a liver specific perfusion model. In-vivo liver ablation temperatures were collected and used as the training data for the optimization of a muscle perfusion model for liver tissue.
Author: Yahya Rahmat-Samii
Publisher: John Wiley & Sons
ISBN: 1119683297
Category : Technology & Engineering
Languages : en
Pages : 624
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Book Description
A guide to the theory and recent development in the medical use of antenna technology Antenna and Sensor Technologies in Modern Medical Applications offers a comprehensive review of the theoretical background, design, and the latest developments in the application of antenna technology. Written by two experts in the field, the book presents the most recent research in the burgeoning field of wireless medical telemetry and sensing that covers both wearable and implantable antenna and sensor technologies. The authors review the integrated devices that include various types of sensors wired within a wearable garment that can be paired with external devices. The text covers important developments in sensor-integrated clothing that are synonymous with athletic apparel with built-in electronics. Information on implantable devices is also covered. The book explores technologies that utilize both inductive coupling and far field propagation. These include minimally invasive microwave ablation antennas, wireless targeted drug delivery, and much more. This important book: Covers recent developments in wireless medical telemetry Reviews the theory and design of in vitro/in vivo testing Explores emerging technologies in 2D and 3D printing of antenna/sensor fabrication Includes a chapter with an annotated list of the most comprehensive and important references in the field Written for students of engineering and antenna and sensor engineers, Antenna and Sensor Technologies in Modern Medical Applications is an essential guide to understanding human body interaction with antennas and sensors.
Author: Slawomir Koziel
Publisher: Springer Nature
ISBN: 303038926X
Category : Technology & Engineering
Languages : en
Pages : 411
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Book Description
This book discusses surrogate modeling of high-frequency structures including antenna and microwave components. The focus is on constrained or performance-driven surrogates. The presented techniques aim at addressing the limitations of conventional modeling methods, pertinent to the issues of dimensionality and parameter ranges that need to be covered by the surrogate to ensure its design utility. Within performance-driven methodologies, mitigation of these problems is achieved through appropriate confinement of the model domain, focused on the regions promising from the point of view of the relevant design objectives. This enables the construction of reliable surrogates at a fraction of cost required by conventional methods, and to accomplish the modeling tasks where other techniques routinely fail. The book provides a broad selection of specific frameworks, extensively illustrated using examples of real-world microwave and antenna structures along with numerous design examples. Furthermore, the book contains introductory material on data-driven and physics-based surrogates. The book will be useful for the readers working in the area of high-frequency electronics, including microwave engineering, antenna design, microwave photonics, magnetism, especially those that utilize electromagnetic (EM) simulation models in their daily routines. Covers performance-driven and constrained modeling methods, not available in other books to date; Discusses of a wide range of practical case studies including a variety of microwave and antenna structures; Includes design applications of the presented modeling frameworks, including single- and multi-objective parametric optimization.
Author: José de Jesús Agustín Flores Cuautle
Publisher: Springer Nature
ISBN: 303146933X
Category : Technology & Engineering
Languages : en
Pages : 426
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Book Description
This book reports on cutting-edge research and best practices in the broad fiel of biomedical engineering. Based on the XLVI Mexican Congress on Biomedical Engineering, CNIB 2023, held on November 2-4, 2023 in Villahermosa Tabasco, Mexico, this first volume of the proceedings covers research topics in biomedical signals and image processing, artificial intelligence, biosensors, and wearable systems, with applications ranging from disease classification and diagnosis, to health monitoring and medical therapy. All in all, this book provides a timely snapshot on state-of-the-art achievements in biomedical engineering and current challenges in the field. It addresses both researchers and professionals, and it is expect to foster future collaborations between the two groups, as well as international collaborations. .
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Category : Aeronautics
Languages : en
Pages : 456
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Book Description
Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.
Author: Eric van Sonnenberg
Publisher: Springer Science & Business Media
ISBN: 0387286748
Category : Medical
Languages : en
Pages : 554
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Book Description
There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.
Author: Trupti Ranjan Lenka
Publisher: Springer Nature
ISBN: 9819944953
Category : Technology & Engineering
Languages : en
Pages : 519
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Book Description
This book presents select proceedings of the International Conference on Micro and Nanoelectronics Devices, Circuits and Systems (MNDCS-2023). The book includes cutting-edge research papers in the emerging fields of micro and nanoelectronics devices, circuits, and systems from experts working in these fields over the last decade. The book is a unique collection of chapters from different areas with a common theme and is immensely useful to academic researchers and practitioners in the industry who work in this field.
Author: Alexandru Morega
Publisher: Academic Press
ISBN: 0128178973
Category : Science
Languages : en
Pages : 320
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Book Description
Mathematical and numerical modelling of engineering problems in medicine is aimed at unveiling and understanding multidisciplinary interactions and processes and providing insights useful to clinical care and technology advances for better medical equipment and systems. When modelling medical problems, the engineer is confronted with multidisciplinary problems of electromagnetism, heat and mass transfer, and structural mechanics with, possibly, different time and space scales, which may raise concerns in formulating consistent, solvable mathematical models. Computational Medical Engineering presents a number of engineering for medicine problems that may be encountered in medical physics, procedures, diagnosis and monitoring techniques, including electrical activity of the heart, hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods. The authors discuss the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling (e.g., criteria for well-posed problems); physics scaling (homogenization techniques); Constructal Law criteria in morphing shape and structure of systems with internal flows; computational domain construction (CAD and, or reconstruction techniques based on medical images); numerical modelling issues, and validation techniques used to ascertain numerical simulation results. In addition, new ideas and venues to investigate and understand finer scale models and merge them into continuous media medical physics are provided as case studies. Presents the fundamentals of mathematical and numerical modeling of engineering problems in medicine Discusses many of the most common modelling scenarios for Biomedical Engineering, including, electrical activity of the heart hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods Includes discussion of the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling, physics scaling, Constructal Law criteria in morphing shape and structure of systems with internal flows, computational domain construction, numerical modelling issues, and validation techniques used to ascertain numerical simulation results
