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Author: Henry H. Heng
Publisher: World Scientific
ISBN: 9814520853
Category : Science
Languages : en
Pages : 463
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Book Description
"Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research."--
Author: Henry H. Heng
Publisher: World Scientific
ISBN: 9814520853
Category : Science
Languages : en
Pages : 463
Get Book Here
Book Description
"Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research."--
Author: Henry H Q Heng
Publisher: World Scientific
ISBN: 9814520861
Category : Medical
Languages : en
Pages : 463
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Book Description
Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology.This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Stephen Hilgartner
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 750
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Book Description
Author: Maria Laura Corradi
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 680
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Book Description
Author: S. Lochlann Jain
Publisher: Univ of California Press
ISBN: 0520276566
Category : Social Science
Languages : en
Pages : 300
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Book Description
"Cancer can kill: this fact makes it concrete. Still, it's a devious knave. Nearly every American will experience it up-close and all too personally, wondering why the billions of research dollars thrown at the word haven't exterminated it from the English language. Like a sapper diffusing a bomb, Jain unscrambles the emotional, bureaucratic, medical, and scientific tropes that create the thing we call cancer. Scientists debate even the most basic facts about the disease, while endlessly generated, disputed, population data produce the appearance of knowledge. Jain takes the vacuum at the center of cancer seriously and demonstrates the need to understand cancer as a set of relationships--economic, sentimental, medical, personal, ethical, institutional, statistical. Malignant analyzes the peculiar authority of the socio-sexual psychopathologies of body parts; the uneven effects of expertise and power; the potentially cancerous consequences of medical procedures such as IVF; the huge industrial investments that manifest themselves as bone-cold testing rooms; the legal mess of medical malpractice law; and the teeth-grittingly jovial efforts to smear makeup and wigs over the whole messy problem of bodies spiraling into pain and decay. Malignant examines the painful cognitive dissonances produced by the ways a culture that has relished dazzling success in every conceivable arena have twisted one of its staunchest failures into an economic triumph. The intractable foil to American achievement, cancer hands us -- on a silver platter and ready for Jain's incisively original dissection -- our sacrifice to the American Dream"--
Author: Scientific American Editors
Publisher: Scientific American
ISBN: 1466859075
Category : Medical
Languages : en
Pages : 280
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Book Description
The past few years have seen tremendous strides in our understanding of cancer, including new hypotheses about its genetic origins and new treatment alternatives using the body’s own immune response. In this eBook, The Science of Cancer, we examine what we know and what we’re finding out about this scourge of humankind. We delve into the molecular basis and complex causes of cancer, the arguments for and against screenings, new and targeted therapies, and minimizing risk. In “How Cancer Arises,” Robert Weinberg presents what has been the central dogma of cancer genetics, which says that a handful of essential mutations in specific genes lead to tumor growth; however, recent discoveries are challenging this theory, as we see in “Untangling the Roots of Cancer” and “Stem Cells: The Real Culprits in Cancer?” Early detection of cancer is important for treatment, but not all screening tests are created equal. In “The Great Prostate Cancer Debate,” Mark Garnick lays out the controversy over the value of the prostate-specific antigen test for prostate cancer and the rationale against screening. With our increasing knowledge of cancer’s causes, exciting targeted therapies are on the rise, including homing in on stem cells, making use of viruses, and manipulating the immune system as we see in “A New Ally against Cancer,” which focuses on treatment with therapeutic vaccines. Does this mean a cure is around the corner? Perhaps not, according to Scientific American Editor Dina Fine Maron in “Can We Truly ‘Cure’ Cancer?” But with remission rates rising for certain types of cancers and with new discoveries opening up further avenues of research, there is reason for optimism.
Author: Robert E. Bristow
Publisher: CRC Press
ISBN: 0429578857
Category : Medical
Languages : en
Pages : 437
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Book Description
Updated and expanded, the third edition of Surgery for Ovarian Cancer focuses on essential techniques for the effective management of ovarian cancer. It reflects the most contemporary science and surgical applications for the management of patients with ovarian cancer and related peritoneal surface malignancies. This new edition takes a step-by-step approach and includes new intraoperative photographs and videos illustrating surgical procedures. It is principally devoted to the technical aspects of cytoreductive surgery, with chapters divided according to anatomic region. The chapters cover relevant anatomical considerations, surgical challenges specific to each region, and operative approaches and techniques favored by the authors. The list of contributing authors has been expanded from the previous edition and includes international and world-renowned experts from the fields of gynecologic oncology and surgical oncology. The topics of minimally invasive surgery, secondary cytoreduction, palliative surgery, and postoperative care are also covered in detail. New to the third edition are chapters on preoperative risk stratification, regional therapeutics and peritonectomy procedures, and quality assurance relating to ovarian cancer surgery. This comprehensive text is essential reading for all practitioners working with patients with ovarian cancers.
Author: Athena Aktipis
Publisher: Princeton University Press
ISBN: 0691163847
Category : Medical
Languages : en
Pages : 256
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Book Description
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
Author: Anya Plutynski
Publisher: Oxford University Press
ISBN: 0199967466
Category : Science
Languages : en
Pages : 272
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Book Description
In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.
