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Author: Hardeep Singh Tuli
Publisher: Springer
ISBN: 9811358745
Category : Medical
Languages : en
Pages : 191
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Book Description
The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.
Author: Hardeep Singh Tuli
Publisher: Springer
ISBN: 9811358745
Category : Medical
Languages : en
Pages : 191
Get Book Here
Book Description
The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.
Author: H.P. Vasantha Rupasinghe
Publisher: MDPI
ISBN: 3036500006
Category : Science
Languages : en
Pages : 346
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Book Description
Flavonoids are ubiquitously present in plant-based foods and natural health products. The molecule of flavonoids is characterized by a 15-carbon skeleton of C6–C3–C6, with the different structural configuration of subclasses. The major subclasses of flavonoids with health-promotional properties are the flavanols or catechins (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavonols (e.g., quercetin glycosides from apples, berries, and onion), the flavanones (e.g., naringenin from citrus), the anthocyanins (e.g., cyanidin-3-O-glucoside from berries), and the isoflavones (e.g., genistein from soya beans). Scientific evidence has strongly shown that regular intake of dietary flavonoids in efficacious amounts reduces the risk of oxidative stress- and chronic inflammation-mediated pathogenesis of human diseases such as cardiovascular disease, certain cancers, and neurological disorders. The physiological benefits of dietary flavonoids have been demonstrated to be due to multiple mechanisms of action, including regulating redox homeostasis, epigenetic regulations, activation of survival genes and signaling pathways, regulation of mitochondrial function and bioenergetics, and modulation of inflammation response. The role of flavonoids on gut microbiota and the impact of microbial metabolites of flavonoids on optimal health has begun to unravel. The complex physiological modulations of flavonoid molecules are due to their structural diversity. However, some flavonoids are not absorbed well, and their bioavailability could be enhanced through structural modifications and applications of nanotechnology, such as encapsulation. This Special Issue consists of four review articles on flavonoids and 15 original research articles, which cover the latest findings on the role of dietary flavonoids and their derivatives in disease prevention and treatment.
Author: Pandurangan, Ashok Kumar
Publisher: IGI Global
ISBN: 1799892603
Category : Medical
Languages : en
Pages : 643
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Book Description
Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.
Author: José Justino
Publisher: BoD – Books on Demand
ISBN: 953513423X
Category : Science
Languages : en
Pages : 486
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Book Description
Flavonoids are abundant secondary metabolites found in plants and fungi that have various roles in these organisms, including pigmentation, cell signalling, plant defence and inter-organism communication. Due to their abundance in nature, flavonoids are also important components of the human diet, and the last four decades have seen an intense study focused on the structure characterization of flavonoids and on their roles in mammal metabolism. This book reviews most of the well-established activities of flavonoids, and we also present more recent research studies on the area of flavonoids, including the chemical aspects of structure characterization of flavonoids, the biosynthesis of flavonoids in model plants as well as their role in abiotic stress situations and in agriculture, the role of flavonoids in metabolism and health and their importance in foods, from consumption to their use as bioactive components.
Author: Yearul Kabir
Publisher: Academic Press
ISBN: 0128161515
Category : Technology & Engineering
Languages : en
Pages : 522
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Book Description
Functional Foods in Cancer Prevention and Therapy presents the wide range of functional foods associated with the prevention and treatment of cancer. In recent decades, researchers have made progress in our understanding of the association between functional food and cancer, especially as it relates to cancer treatment and prevention. Specifically, substantial evidence from epidemiological, clinical and laboratory studies show that various food components may alter cancer risk, the prognosis after cancer onset, and the quality of life after cancer treatment. The book documents the therapeutic roles of well-known functional foods and explains their role in cancer therapy. The book presents complex cancer patterns and evidence of the effective ways to control cancers with the use of functional foods. This book will serve as informative reference for researchers focused on the role of food in cancer prevention and physicians and clinicians involved in cancer treatment.
Author: Phuc Van Pham
Publisher: BoD – Books on Demand
ISBN: 9535129996
Category : Medical
Languages : en
Pages : 570
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Book Description
Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.
Author: Fazlul H. Sarkar
Publisher: Springer Science & Business Media
ISBN: 9400726309
Category : Medical
Languages : en
Pages : 383
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Book Description
This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
Author: Kulmira Nurgali
Publisher: Frontiers Media SA
ISBN: 2889454827
Category :
Languages : en
Pages : 245
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Book Description
Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
Author: Ulf Stahl
Publisher: Springer
ISBN: 3540705368
Category : Technology & Engineering
Languages : en
Pages : 280
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Book Description
This resource examines trends in modern biotechnology, covering all aspects of this interdisciplinary field.
Author: Jeremy P. E. Spencer
Publisher: CRC Press
ISBN: 1439848270
Category : Medical
Languages : en
Pages : 467
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Book Description
Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. Flavonoids and Related Compounds: Bioavailability and Function examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds. Profiling
