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Author: Byron Jones
Publisher: CRC Press
ISBN: 1439861420
Category : Mathematics
Languages : en
Pages : 440
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Book Description
Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture. The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition: Contains seven new chapters written in the form of short case studies that address re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from phase two to phase three, establishing proof of concept, and recalculating the sample size using conditional power Employs the R package Crossover, specially created to accompany the book and provide a graphical user interface for locating designs in a large catalog and for searching for new designs Includes updates regarding the use of period baselines and the analysis of data from very small trials Reflects the availability of new procedures in SAS, particularly proc glimmix Presents the SAS procedure proc mcmc as an alternative to WinBUGS for Bayesian analysis Complete with real data and downloadable SAS code, Design and Analysis of Cross-Over Trials, Third Edition provides a practical understanding of the latest methods along with the necessary tools for implementation.
Author: Byron Jones
Publisher: CRC Press
ISBN: 1439861420
Category : Mathematics
Languages : en
Pages : 440
Get Book Here
Book Description
Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture. The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition: Contains seven new chapters written in the form of short case studies that address re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from phase two to phase three, establishing proof of concept, and recalculating the sample size using conditional power Employs the R package Crossover, specially created to accompany the book and provide a graphical user interface for locating designs in a large catalog and for searching for new designs Includes updates regarding the use of period baselines and the analysis of data from very small trials Reflects the availability of new procedures in SAS, particularly proc glimmix Presents the SAS procedure proc mcmc as an alternative to WinBUGS for Bayesian analysis Complete with real data and downloadable SAS code, Design and Analysis of Cross-Over Trials, Third Edition provides a practical understanding of the latest methods along with the necessary tools for implementation.
Author: Byron Jones
Publisher: CRC Press
ISBN: 9780412606403
Category : Mathematics
Languages : en
Pages : 412
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Book Description
The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include: A new chapter on bioequivalence Recently developed methods for analyzing longitudinal continuous and categorical data Real-world examples using the SAS system A comprehensive catalog of designs, datasets, and SAS programs available on a companion Web site at www.crcpress.com The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come.
Author: National Institute on Drug Abuse. Community Epidemiology Work Group
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 404
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 408
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Book Description
Author: M Lindsay Grayson
Publisher: CRC Press
ISBN: 1444147528
Category : Medical
Languages : en
Pages : 3211
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Book Description
'I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Author: Hartmut Porst
Publisher: John Wiley & Sons
ISBN: 1405178728
Category : Medical
Languages : en
Pages : 416
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Book Description
The new international standard reference work for sexual medicine Written under the auspices of the International Society for Sexual Medicine, (www.issm.info), the leading professional society in sexual medicine and founder of the most influential journal in the field, The Journal of Sexual Medicine, published by Blackwell Publishing Comprehensive coverage of the full range of diagnostic and treatment options in all aspects of male and female sexual dysfunctions Provides information on recent progress in pharmacologic approaches, including the highly successful drug treatments for ED Useful for any part of the patient-clinician consultation, from gathering symptoms to diagnosis to treatment to reports on potential and developing treatments
Author: Chinyere K. Osuji
Publisher: NYU Press
ISBN: 1479878618
Category : Social Science
Languages : en
Pages : 292
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Book Description
How interracial couples in Brazil and the US navigate racial boundaries How do people understand and navigate being married to a person of a different race? Based on individual interviews with forty-seven black-white couples in two large, multicultural cities—Los Angeles and Rio de Janeiro—Boundaries of Love explores how partners in these relationships ultimately reproduce, negotiate, and challenge the “us” versus “them” mentality of ethno-racial boundaries. By centering marriage, Chinyere Osuji reveals the family as a primary site for understanding the social construction of race. She challenges the naive but widespread belief that interracial couples and their children provide an antidote to racism in the twenty-first century, instead highlighting the complexities and contradictions of these relationships. Featuring black husbands with white wives as well as black wives with white husbands, Boundaries of Love sheds light on the role of gender in navigating life married to a person of a different color. Osuji compares black-white couples in Brazil and the United States, the two most populous post–slavery societies in the Western hemisphere. These settings, she argues, reveal the impact of contemporary race mixture on racial hierarchies and racial ideologies, both old and new.
Author: Jean Morrissey
Publisher: Bloomsbury Publishing
ISBN: 1350310751
Category : Medical
Languages : en
Pages : 306
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Book Description
This book introduces students and professionals, family and friends of people with eating disorders to the key concepts and skills that underpin a holistic and recovery orientated approach to the care of eating disorders. It provides an overview of the main professional practice and ethical issues, which workers are likely to be confronted with in their area of work and family members are likely to face when trying to support loved ones. Each chapter is written by an expert and provides a practical guide for those working and/or living with people affected by eating disorders in different settings. Topics are illustrated through the use of clinical cases and further underpinned by current literature and research relevant to topic area.
Author: Allan Kellehear
Publisher: Columbia University Press
ISBN: 0231167857
Category : Social Science
Languages : en
Pages : 284
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Book Description
This unique book recounts the experience of facing one’s death solely from the dying person’s point of view rather than from the perspective of caregivers, survivors, or rescuers. Such unmediated access challenges assumptions about the emotional and spiritual dimensions of dying, showing readers that—along with suffering, loss, anger, sadness, and fear—we can also feel courage, love, hope, reminiscence, transcendence, transformation, and even happiness as we die. A work that is at once psychological, sociological, and philosophical, this book brings together testimonies of those dying from terminal illness, old age, sudden injury or trauma, acts of war, and the consequences of natural disasters and terrorism. It also includes statements from individuals who are on death row, in death camps, or planning suicide. Each form of dying addressed highlights an important set of emotions and narratives that often eclipses stereotypical renderings of dying and reflects the numerous contexts in which this journey can occur outside of hospitals, nursing homes, and hospices. Chapters focus on common emotional themes linked to dying, expanding and challenging them through first-person accounts and analyses of relevant academic and clinical literature in psycho-oncology, palliative care, gerontology, military history, anthropology, sociology, cultural and religious studies, poetry, and fiction. The result is an all-encompassing investigation into an experience that will eventually include us all and is more surprising and profound than anyone can imagine.
Author: Ann Laura Stoler
Publisher: Duke University Press
ISBN: 9780822337249
Category : Family & Relationships
Languages : en
Pages : 572
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Book Description
DIVA groundbreaking interdisciplinary collection that rethinks the connection between the intimate and United States colonial and postcolonial histories./div
