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Author:
Publisher: Ed. Techniques Ingénieur
ISBN:
Category :
Languages : fr
Pages : 20
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Book Description
Author:
Publisher: Ed. Techniques Ingénieur
ISBN:
Category :
Languages : fr
Pages : 20
Get Book Here
Book Description
Author:
Publisher:
ISBN: 9782759824540
Category :
Languages : fr
Pages :
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Book Description
Author: ALAIN.. ROUSSEL
Publisher:
ISBN:
Category :
Languages : fr
Pages :
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Book Description
LA CRISTALLOGRAPHIE DES MACROMOLECULES BIOLOGIQUES PERMET D'OBTENIR, A PARTIR DU SPECTRE DE DIFFRACTION AUX RAYONS X DE MONOCRISTAUX, LA STRUCTURE TRIDIMENSIONNELLE DE L'OBJET BIOLOGIQUE. ELLE COMPORTE QUATRE ETAPES PRINCIPALES: LA CRISTALLOGENESE, L'ENREGISTREMENT DU SPECTRE DE DIFFRACTION, L'OBTENTION DES PHASES ET LA CONSTRUTION DU MODELE. CE TRAVAIL DECRIT LA CONCEPTION DE LOGICIELS POUR LES PREMIERE ET DERNIERE ETAPES. DANS LA PREMIERE PARTIE, NOUS AVONS ECRIT UN LOGICIEL D'INTERROGATION EN LANGAGE NATUREL (ANGLAIS) D'UNE BASE DE DONNEES DE CRISTALLISATIONS DE MACROMOLECULES BIOLOGIQUES. NOUS AVONS FAIT UN ETUDE STATISTIQUE SUR L'UTILISATION DES DIFFERENTS AGENTS PRECIPITANTS. NOUS AVONS ENSUITE REALISE UN PROGRAMME D'ANALYSE DES CONTACTS CRISTALLINS INTERMOLECULAIRES. NOUS AVONS COMPARE CES INTERACTIONS AVEC CELLES EXISTANT A L'ETAT NATUREL DANS LES MULTIMERES PROTEIQUES. LA DEUXIEME PARTIE DE CE TRAVAIL A ETE CONSACREE A LA REALISATION DE LOGICIELS DE GRAPHISME MOLECULAIRE. NOUS AVONS TOUT D'ABORD ECRIT UNE OPTION PERMETTANT DE REPRESENTER, D'EDITER ET DE MANIPULER LES MOLECULES RELIEES PAR SYMETRIE SUR UN ECRAN GRAPHIQUE. PUIS NOUS AVONS REALISE, DE NOVO, UN LOGICIEL COMPLET DE GRAPHISME MOLECULAIRE: TURBO-FRODO. CE LOGICIEL EST FONDE SUR UNE BASE DE DONNEES ARBORESCENTE. IL PERMET LA MODELISATION ET LA CONSTRUCTION DE MODELES DE MACROMOLECULES DANS DES CARTES DE DENSITE ELECTRONIQUE. LA FACILITE D'UTILISATION ET LA DIVERSITE DES OPTIONS FONT DE CE LOGICIEL UN OUTIL POUR LA CRISTALLOGRAPHIE ET AUSSI POUR LA BIOLOGIE MOLECULAIRE STRUCTURALE
Author: Cavarelli
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Le Du Marie-Hélène
Publisher: EDP Sciences
ISBN: 275982957X
Category : Technology & Engineering
Languages : fr
Pages : 212
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Book Description
Dans le monde du vivant, les mécanismes mis en jeu pour respirer, digérer, grandir, bouger, impliquent des molécules constituées de milliers d’atomes, ce sont les macromolécules. Ces macromolécules circulent, interagissent et se contorsionnent en permanence. Les visualiser à l’échelle atomique constitue une aide incomparable pour comprendre comment elles fonctionnent ou dysfonctionnent, et pour concevoir des médicaments. Les auteurs vous proposent une initiation aux différentes étapes de la cristallographie biologique qui mène de la cristallisation à la structure tridimensionnelle d’une macromolécule. Ce livre fait suite au MOOC « Voyage au cœur du vivant avec des rayons X : la cristallographie ». Il peut en être le compagnon ou être utilisé seul.
Author: Alexander McPherson
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 608
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Book Description
This extensively illustrated book by Alexander McPherson, a master practitioner, accomplishes several important goals: it presents the underlying physical and chemical principles of crystallization in an approachable way; it provides the reader with a biochemical context in which to understand and pursue successful crystal growth; it instructs the reader in practical aspects of the technologies required; and it lays out effective strategies for success that investigators can readily apply to their own experimental questions. This readable volume has been created for every investigator in biomedicine whose studies may require a shift in focus from gene to protein product, as well as chemists and physicists interested in the functions of biologically active macromolecules.
Author: Joel L. Sussman
Publisher: Springer Science & Business Media
ISBN: 9048123399
Category : Science
Languages : en
Pages : 258
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Book Description
Proceedings of the NATO Advanced Study Institute on Integrating Crystallography in the Fight Against Terrorism Erice, Italy 29 May-8 June 2008
Author: Charles W. Carter
Publisher: Gulf Professional Publishing
ISBN: 9780121827779
Category : Computer simulation
Languages : en
Pages : 756
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Book Description
Annotation Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software.
Author: Bernhard Rupp
Publisher: Garland Science
ISBN: 1134064195
Category : Science
Languages : en
Pages : 832
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Book Description
Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.
Author: David Blow
Publisher: OUP Oxford
ISBN: 0191037060
Category : Science
Languages : en
Pages : 325
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Book Description
Outline of Crystallography for Biologists is intended for researchers and students in the biological sciences who require an insight into the methods of X-ray crystallography without needing to learn all the relevant theory. The main text is purely descriptive and is readable by those with minimal mathematical knowledge. Some mathematical detail is given throughout in boxes, but these can be ignored. Theory is limited to the essentials required to comprehend issues of quality. There is an extensive reference section and suggestions for further reading for those who wish to delve deeper. The first part 'Fundamentals' presents the underlying ideas which allow x-ray structure analysis to be carried out and provides an appropriate background to courses in structural determination. The second part 'Practice' gives more information about the procedures employed in the course of crystal structure determination. The emphasis is on the quality measures of X-ray diffraction analysis to give the reader a critical insight into the quality and accuracy of a structure determination and to enable the reader to appreciate which parts of a structure determination may have caused special difficulty. There is no pretence of completeness and many matters discussed in standard crystallography texts are deliberately omitted. However, issues not brought out in the standard texts are discussed, making it a useful resource for non-practising crystallographers as well.
