Creatine Kinase Isoenzymes PDF Download
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Author: H. Lang
Publisher: Springer Science & Business Media
ISBN: 3642680410
Category : Medical
Languages : en
Pages : 334
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Book Description
No one has counted the enzymes in the human organism, and probably their profuse number can only be estimated from the restrictions the finite mass of genetic material imposes. Still, nu merous catalytic activities have been identified and investigated for their clinical relevance. After one century of such research, surprisingly, only a handful of enzymes has survived the stern trial of clinical application to find regular medical use. Dis regarding genetic defects, most of the diagnostically used en zymes participate in metabolic conversions fundamental to life: the utilization, transfer or fixation of vital nutrients or of cheJ,llical energy. Creatine kinase is central to the function of the mitochond rion, the cellular power generator. The wider distribution of this enzyme is linked to tissues whose physiology crucially relies on an adaptable supply of energy, notably skeletal muscle, the brain, and the heart. Just as these three tissues vary in their pre ference for different energy sources, each produces a different isoenzyme of creatine kinase. Accordingly, the finding of elevat ed creatine kinase activity in blood can lead to a variety of interpretations, but in practice the diagnosis of acute myocardial infarction is the major consideration.
Author: H. Lang
Publisher: Springer Science & Business Media
ISBN: 3642680410
Category : Medical
Languages : en
Pages : 334
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Book Description
No one has counted the enzymes in the human organism, and probably their profuse number can only be estimated from the restrictions the finite mass of genetic material imposes. Still, nu merous catalytic activities have been identified and investigated for their clinical relevance. After one century of such research, surprisingly, only a handful of enzymes has survived the stern trial of clinical application to find regular medical use. Dis regarding genetic defects, most of the diagnostically used en zymes participate in metabolic conversions fundamental to life: the utilization, transfer or fixation of vital nutrients or of cheJ,llical energy. Creatine kinase is central to the function of the mitochond rion, the cellular power generator. The wider distribution of this enzyme is linked to tissues whose physiology crucially relies on an adaptable supply of energy, notably skeletal muscle, the brain, and the heart. Just as these three tissues vary in their pre ference for different energy sources, each produces a different isoenzyme of creatine kinase. Accordingly, the finding of elevat ed creatine kinase activity in blood can lead to a variety of interpretations, but in practice the diagnosis of acute myocardial infarction is the major consideration.
Author: Gajja S. Salomons
Publisher: Springer Science & Business Media
ISBN: 1402064861
Category : Medical
Languages : en
Pages : 359
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Book Description
This volume places emphasis on the intricate interplay between creatine and creatine kinase function on one hand and proper brain function, neurodegenerative disease and/or neuroprotection on the other. The book, compiled by outstanding experts, provides a key reference summarizing the state-of-the-art in creatine and creatine kinase research. It is a must-read for understanding the links between creatine metabolism and neuroprotection as well as neurodegenerative disease.
Author: Christian Vial
Publisher: Nova Publishers
ISBN: 9781594547157
Category : Medical
Languages : en
Pages : 296
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Book Description
Creatine kinases and arginine kinases are an historical model in enzymology. They belong to the large family of phosphagen kinases which transfer a phosphoryl group from ATP to a nitrogen atom within a guanidinium group to form that was called by the early muscle physiologists a 'phosphagen'. These compounds and the enzymes that catalyse their formation and use are present in cells with important and rapidly fluctuating energy requirements.
Author: National Institute of Neurological Diseases and Stroke
Publisher:
ISBN:
Category : Muscular dystrophy
Languages : en
Pages : 26
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Book Description
Author: Michael Benatar
Publisher: Springer Science & Business Media
ISBN: 1597451061
Category : Medical
Languages : en
Pages : 474
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Book Description
A Certain Kind of Wisdom In Plato’s Apology, the Greek philosopher Socrates is on trial to defend himself against the allegation of corrupting the youth of Athens. Socrates denies this charge and offers an alternate reason for why he is on trial. He explains, “[w]hat has caused my reputation is none other than a certain kind of wisdom. What kind of wisdom? Human wisdom, perhaps(1). ” He proceeds to tell the story of his friend Chaerophon, who once asked the Oracle at Delphi whether there was anyone wiser than Socrates. The Oracle answered that there was not. Socrates did not agree and thought that he would try to prove the Oracle wrong. And so he set about seeking out Athenians with a reputation for wisdom in various regards in order to test their claims to knowledge through questioning. He discovered many with false claims to knowledge and none with genuine wisdom and ultimately concluded that he was the wisest. He reached this conclusion not because of any special knowledge he possessed that others did not, but rather because he recognized his own lack of knowledge and strived to learn more, while others thought that they were kno- edgeable but were not. Socrates’ conclusion that there is wisdom in recognizing the limitations of accepted knowledge represents the motivation for this book.
Author: Paul D. Thompson
Publisher: Springer Nature
ISBN: 3030333043
Category : Medical
Languages : en
Pages : 191
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Book Description
This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.
Author: Vijay Kumar
Publisher: Springer
ISBN: 9811081867
Category : Medical
Languages : en
Pages : 174
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Book Description
This book is a practical guidebook in biochemistry, for medical as well as life sciences' students. The book covers reference values, sample collection procedure and detailed protocol to perform experiments. Each experiment starts with a brief introduction of the protocol, followed by specimen requirements and procedure. The procedures are presented in a very lucid manner and discuss details of calculations and clinical interpretations,The book is divided into 29 chapters, It offers references, general guidelines and abbreviations and provides principles and procedures of clinical biochemistry tests, along with their diagnostic importance.
Author: Tulio E. Bertorini
Publisher: Elsevier Health Sciences
ISBN: 0702038695
Category : Medical
Languages : en
Pages : 661
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Book Description
In this unique book, Dr. Bertorini guides you through more than 100 cases that demonstrate the diagnosis and management of a wide range of common and rare neuromuscular disorders. No other reference boasts such a large array of clinical studies devoted to all areas of this broad topic! Each case study reviews the etiologies, pathogenesis, differential diagnosis, and management of a particular disorder, helping you not only recognize its presentation, but also determine a diagnosis and the best treatment plans for your patients. You'll also find expert guidance on the basic mechanisms of neuromuscular disorders, clinical examination, and diagnostic tests—including EMG, muscle biopsy, genetic testing, and more. - More than 100 detailed case studies explore both common and rare neuromuscular disorders and the treatment protocols for each, equipping you with the knowledge you need to confidently manage any challenge. Each case includes a summary of important points or highlights of the study. - Case studies are arranged either by complaint or by diagnosis so that you can successfully manage your patients with or without an initial diagnosis. - Comprehensive coverage of EMGs and nerve conduction studies and other diagnostic tests, including muscle and nerve biopsies and genetic testing, helps you accurately diagnose nerve, muscle, and neuromuscular transmission disorders. - Detailed discussions of treatment plans and commonly used drugs enhance your management of autoimmune disorders, painful neuropathy, dysautonomia, and other neuromuscular disorders. - A reader-friendly format takes you step by step through the diagnosis and treatment of neuromuscular disorders, from the basic anatomy and physiology of the nerve and muscle through to clinical evaluation, diagnostic testing, and therapy. - More than 350 high-quality illustrations, including full-color patient photographs, biopsies, and EMG tracings, make complex concepts easier to understand and apply.
Author: Gary D. Lopaschuk
Publisher: Springer
ISBN: 1493912275
Category : Science
Languages : en
Pages : 301
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Book Description
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
Author: Hector Chinoy
Publisher: Oxford University Press
ISBN: 0198754124
Category : Medical
Languages : en
Pages : 205
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Book Description
This short handbook summarises the clinical features, epidemiology, current treatment paradigms, and ongoing trials for the idiopathic inflammatory myopathies (IMM). Aimed at both trainees and physicians with an aim to improving the quality of care for people with IMM.
