Community Series in the Role of CD1- and MR1-restricted T cells in Immunity and Disease, Volume II PDF Download
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Author: Luc Van Kaer
Publisher: Frontiers Media SA
ISBN: 2832554830
Category : Medical
Languages : en
Pages : 177
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Book Description
This is the second volume in the series, the Role of CD1- and MR1-restricted T cells in Immunity and Disease. Please see volume I here. CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen-presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b, and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which include Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory, and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α or α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells.
Author: Luc Van Kaer
Publisher: Frontiers Media SA
ISBN: 2832554830
Category : Medical
Languages : en
Pages : 177
Get Book Here
Book Description
This is the second volume in the series, the Role of CD1- and MR1-restricted T cells in Immunity and Disease. Please see volume I here. CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen-presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b, and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which include Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory, and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α or α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells.
Author: Rob Townsend
Publisher:
ISBN:
Category : Social workers
Languages : en
Pages :
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Book Description
Author: Jianhua Wang
Publisher: Frontiers Media SA
ISBN: 2832514979
Category : Science
Languages : en
Pages : 296
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Book Description
Author: Peter Aggleton
Publisher: Routledge
ISBN: 1135360022
Category : Health & Fitness
Languages : en
Pages : 504
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Book Description
Since the beginnings of time, people have been interested in sex - the form it takes, the pleasure it can give, the circumstances in which it occurs, and what it means - both for the individuals concerned and to society more generally. Often seen as a synonym for love, sometimes as an expression of power, and infrequently as a means of exploitation and abuse, sex is a complex and multi-faceted aspect of human behaviour that has been written about by numerous writers and theorists worldwide. This book offers an introduction to the central debates in sexuality research. Among the issues examined are the social and cultural dimensions of sex, human sexuality and sex research. It will be of use to students of sociology, cultural studies, and health and behavioural studies.
Author: Richard Guy Parker
Publisher: Psychology Press
ISBN: 9781857288117
Category : Health & Fitness
Languages : en
Pages : 504
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Book Description
This work offers an introduction to the central debates in sexuality research. Among the issues examined are the social and cultural dimensions of sex, human sexuality and sex research.
Author: Gilchrist, Alison
Publisher: Policy Press
ISBN: 1447327845
Category : Social Science
Languages : en
Pages : 216
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Book Description
The only up-to-date, accessibly written short guide to community development, this third edition offers an invaluable and authoritative introduction. Fully updated to reflect changes in policy, practice, economics and culture, it will equip readers with an understanding of the history and theory of community development, as well as practical guidance on how to do it. This is a key text for all students and practitioners working with communities. It includes: • a broad overview of core themes, concepts, basic practices and key issues in community development; • an analysis of the impact of COVID-19 on community life and well-being, along with the implications for longer-term community support; • additional brand new content on the pressing issues of democratic decline, social fragmentation and isolation, social care pressures, technological developments and climate change.
Author: Luca Maria Aiello
Publisher: Springer
ISBN: 303005411X
Category : Technology & Engineering
Languages : en
Pages : 906
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Book Description
This book highlights cutting-edge research in the field of network science, offering scientists, researchers, students and practitioners a unique update on the latest advances in theory, together with a wealth of applications. It presents the peer-reviewed proceedings of the VII International Conference on Complex Networks and their Applications (COMPLEX NETWORKS 2018), which was held in Cambridge on December 11–13, 2018. The carefully selected papers cover a wide range of theoretical topics such as network models and measures; community structure and network dynamics; diffusion, epidemics and spreading processes; and resilience and control; as well as all the main network applications, including social and political networks; networks in finance and economics; biological and neuroscience networks; and technological networks.
Author: Walter Simon de Boef
Publisher: Routledge
ISBN: 1136474862
Category : Nature
Languages : en
Pages : 458
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Book Description
The conservation and sustainable use of biodiversity are issues that have been high on the policy agenda since the first Earth Summit in Rio in 1992. As part of efforts to implement in situ conservation, a methodology referred to as community biodiversity management (CBM) has been developed by those engaged in this arena. CBM contributes to the empowerment of farming communities to manage their biological resources and make informed decisions on the conservation and use of agrobiodiversity. This book is the first to set out a clear overview of CBM as a methodology for meeting socio-environmental changes. CBM is shown to be a key strategy that promotes community resilience, and contributes to the conservation of plant genetic resources. The authors present the underlying concepts and theories of CBM as well as its methodology and practices, and introduce case studies primarily from Brazil, Ethiopia, France, India, and Nepal. Contributors include farmers, leaders of farmers’ organizations, professionals from conservation and development organizations, students and scientists. The book offers inspiration to all those involved in the conservation and use of agrobiodiversity within livelihood development and presents ideas for the implementation of farmers’ rights. The wide collection of experiences illustrates the efforts made by communities throughout the world to cope with change while using diversity and engaging in learning processes. It links these grassroots efforts with debates in policy arenas as a means to respond to the unpredictable changes, such as climate change, that communities face in sustaining their livelihoods.
Author: Malka Simkovich
Publisher: Lexington Books
ISBN: 1498542433
Category : Religion
Languages : en
Pages : 217
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Book Description
This book explores two kinds of universalist thought that circulated among Jews in the Greco-Roman world. The first, which is founded on the idea that all people may worship the One True God in an engaged and sustained manner, originates in biblical prophetic literature. The second, which underscores a common ethic that all people share, arose in the second century bce. This study offers one definition of Jewish universalism that applies to both of these types of universalist thought: universalist literature presumes that all people, regardless of religion and ethnicity, have access to a relationship with the Israelite God and the benefits promised to those loyal to this God, without demanding that they participate in the Israelite community as a Jew. This book opens with an exploration of four types of relationships between Israelites and non-Israelites in biblical prophetic literature: Israel as Subjugators, Israel as Standard-Bearers, Naturalized Nations, and Universalized Worship. In all of these relationships, the foreign nations will acknowledge the One True God, but it is only the Universalized Worship model that offers a truly universalist vision of the end-time. The second section of this book examines how these four relationship models are expressed in Second Temple literature, and the third section studies late Second Temple texts that employ a second kind of universalist thought that emphasizes ethical behavior. This book closes with the suggestion that Ethical Universalist ideas expressed in late Second Temple texts reflect exposure to Stoic thinkers who were developing universalist ideas in the second century BCE.
Author: Armin Lange
Publisher: BRILL
ISBN: 9004189033
Category : Bibles
Languages : en
Pages : 1015
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Book Description
The Dead Sea Scrolls enrich many areas of biblical research, as well as the study of ancient and rabbinic Judasim, early Christian and other ancient literatures, languages, and cultures. With nearly all Dead Sea Scrolls published, it is now time to integrate the Dead Sea Scrolls fully into the various disciplines that benefit from them. This two-volume collection of essays answers this need. It represents the proceedings of a conference jointly organized by the Hebrew University of Jerusalem and the University of Vienna in Vienna on February 11 14, 2008.
