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Author: William Sargent
Publisher: University Press of New England
ISBN: 1611687160
Category : Nature
Languages : en
Pages : 145
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Book Description
Surviving almost unmolested for 300 million years, the horseshoe crab is now the object of an intense legal and ethical struggle involving marine biologists, environmentalists, US government officials, biotechnologists, and international corporations. The source of this friction is the discovery 25 years ago that the blood of these ancient creatures serves as the basis for the most reliable test for the deadly and ubiquitous gram-negative bacteria. These bacteria are responsible for life-threatening diseases like menengitis, typhoid, E. coli, Legionnaire's Disease and toxic shock syndrome. Because every drug certified by the FDA must be tested using the horseshoe crab derivative known as Limulus lysate, a multimillion dollar industry has emerged involving the license to "bleed" horseshoe crabs and the rights to their breeding grounds. Since his youthful fascination with these ancient creatures, William Sargent has spent much of his life observing, studying, and collecting horseshoe crabs. As a result, he presents a thoroughly accessible insider's guide to the discovery of the lysate test, the exploitation of the crabs at the hands of multinational pharmaceutical conglomerates, local fishing interests, and the legal and governmental wrangling over the creatures' ultimate fate. In the end, the story of the horseshoe crab is a sobering reflection on the unintended consequences of scientific progress and the danger of self-regulated industries controlling a limited natural resource.
Author: William Sargent
Publisher: University Press of New England
ISBN: 1611687160
Category : Nature
Languages : en
Pages : 145
Get Book Here
Book Description
Surviving almost unmolested for 300 million years, the horseshoe crab is now the object of an intense legal and ethical struggle involving marine biologists, environmentalists, US government officials, biotechnologists, and international corporations. The source of this friction is the discovery 25 years ago that the blood of these ancient creatures serves as the basis for the most reliable test for the deadly and ubiquitous gram-negative bacteria. These bacteria are responsible for life-threatening diseases like menengitis, typhoid, E. coli, Legionnaire's Disease and toxic shock syndrome. Because every drug certified by the FDA must be tested using the horseshoe crab derivative known as Limulus lysate, a multimillion dollar industry has emerged involving the license to "bleed" horseshoe crabs and the rights to their breeding grounds. Since his youthful fascination with these ancient creatures, William Sargent has spent much of his life observing, studying, and collecting horseshoe crabs. As a result, he presents a thoroughly accessible insider's guide to the discovery of the lysate test, the exploitation of the crabs at the hands of multinational pharmaceutical conglomerates, local fishing interests, and the legal and governmental wrangling over the creatures' ultimate fate. In the end, the story of the horseshoe crab is a sobering reflection on the unintended consequences of scientific progress and the danger of self-regulated industries controlling a limited natural resource.
Author: William Sargent
Publisher: University Press of New England
ISBN: 1584655313
Category : Science
Languages : en
Pages : 137
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Book Description
Surviving almost unmolested for 300 million years, the horseshoe crab is now the object of an intense legal and ethical struggle involving marine biologists, environmentalists, US government officials, biotechnologists, and international corporations. The source of this friction is the discovery 25 years ago that the blood of these ancient creatures serves as the basis for the most reliable test for the deadly and ubiquitous gram-negative bacteria. These bacteria are responsible for life-threatening diseases like menengitis, typhoid, E. coli, Legionnaire's Disease and toxic shock syndrome. Because every drug certified by the FDA must be tested using the horseshoe crab derivative known as Limulus lysate, a multimillion dollar industry has emerged involving the license to "bleed" horseshoe crabs and the rights to their breeding grounds. Since his youthful fascination with these ancient creatures, William Sargent has spent much of his life observing, studying, and collecting horseshoe crabs. As a result, he presents a thoroughly accessible insider's guide to the discovery of the lysate test, the exploitation of the crabs at the hands of multinational pharmaceutical conglomerates, local fishing interests, and the legal and governmental wrangling over the creatures' ultimate fate. In the end, the story of the horseshoe crab is a sobering reflection on the unintended consequences of scientific progress and the danger of self-regulated industries controlling a limited natural resource.
Author: William Sargent
Publisher:
ISBN: 9781684580767
Category : Nature
Languages : en
Pages : 136
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Book Description
A timely look at the exploitation of a species that has helped with the development of countless drugs and is fast becoming endangered. Because every drug certified by the FDA must be tested using the horseshoe crab derivative known as Limulus lysate, a multimillion-dollar industry has emerged involving the license to bleed horseshoe crabs and the rights to their breeding grounds. William Sargent presents a thoroughly accessible insider's guide to the discovery of the lysate test, the exploitation of the horseshoe crab at the hands of multinational pharmaceutical conglomerates, local fishing interests, and the legal and governmental wrangling over the creatures' ultimate fate. In the end, the story of the horseshoe crab is a sobering reflection on the unintended consequences of scientific progress and the danger of self-regulated industries controlling a limited natural resource. This new edition brings the story up to date as companies race to manufacture alternatives to the horseshoe crab blood, which is now essential for testing vaccines such as those being developed to counter COVID-19. However, horseshoe crab populations are still dwindling, with profound implications not only for the future of the crabs themselves but also for the ecosystems that depend on them.
Author: Cynthia Chris
Publisher: Reaktion Books
ISBN: 1789143705
Category : Nature
Languages : en
Pages : 177
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Book Description
What is a crab? What significance do crabs play in the world? In Crab, Cynthia Chris reveals that these charming creatures are social by nature, creative problem-solvers, and invaluable members of the environments in which they live. Their formidable physical forms, their hard-to-harvest and quick-to-spoil flesh, and their sassy demeanor have inspired artists and writers from Vincent van Gogh to Jean-Paul Sartre. Chris sketches vivid portraits of these animals, tracing the history of the crab through its ancient fossil record to its essential role in protecting its own habitats from the threat of climate change.
Author: Chris Sugden
Publisher:
ISBN: 9781874739128
Category : Cromer (England)
Languages : en
Pages : 237
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Book Description
Author:
Publisher:
ISBN:
Category : Habitat (Ecology)
Languages : en
Pages : 506
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Book Description
Author: Carl Nathaniel Shuster
Publisher: Belknap Press
ISBN: 9780674011595
Category : Limulus polyphemus
Languages : en
Pages : 0
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Book Description
This book brings together 20 scientists who have worked on all aspects of horseshoe crab biology to compile the first fully detailed, comprehensive view of Limulus polyphemus. An indispensable resource, the volume describes behavior, natural history, and ecology; anatomy, physiology, distribution, development, and life cycle.
Author: William Sargent
Publisher: UPNE
ISBN: 9781584654681
Category : Biography & Autobiography
Languages : en
Pages : 174
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Book Description
A science writer reflects on his journey into the profession.
Author: Derek Scott
Publisher: Lulu.com
ISBN: 1847996108
Category : Sports & Recreation
Languages : en
Pages : 126
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Book Description
In Judo Games Derek Scott, 3rd Dan and Experienced judo instructor and Dan Grade Examiner, teaches a collection of almost 100 games and exercises with easy to understand diagrams and simple clear explanations, making it easy to introduce them into your club. Judo Games will introduce you to new games and exercises, show you variations of games you use already and remind you of games you used to use in your class. This is the only book of games for a judo or other martial arts club you will ever need.
Author: Kevin L. Williams
Publisher: Springer
ISBN: 3030171485
Category : Medical
Languages : en
Pages : 869
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Book Description
Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.
