Regulation of Cancer Immune Checkpoints PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Regulation of Cancer Immune Checkpoints PDF full book. Access full book title Regulation of Cancer Immune Checkpoints by Jie Xu. Download full books in PDF and EPUB format.
Author: Jie Xu
Publisher: Springer Nature
ISBN: 9811532664
Category : Medical
Languages : en
Pages : 657
Get Book Here
Book Description
This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
Author: György Ferenc Tóth
Publisher: SUNY Press
ISBN: 1438461216
Category : Social Science
Languages : en
Pages : 334
Get Book Here
Book Description
A historical analysis of the transatlantic relations of the American Indian radical sovereignty movement of the late Cold War. From Wounded Knee to Checkpoint Charlie examines the history of the transatlantic alliance between American Indian sovereignty activists and Central European solidarity groups, and their entry into the United Nations in the 1970s and 1980s. In the late Cold War, Native American activists engaged in transnational diplomacy for nation building by putting outside pressure on the US government for a more progressive Indian policy that reached for the full decolonization of Native American communities into independence. By using extensive multinational archival research complemented by interviews, György Ferenc Tóth investigates how older transatlantic images of American Indians influenced the alliance between Native activists and Central European groups, how this coalition developed and functioned, and how the US government and the regimes of the Eastern Bloc responded to this transatlantic alliance. This book not only places the American Indian radical sovereignty movement in an international context, but also recasts it as a transnational struggle, thus connecting domestic US social and political history to the history of Cold War transatlantic relations and global movements.
Author: Ning Cai
Publisher: World Scientific
ISBN: 9813146435
Category : Computers
Languages : en
Pages : 1286
Get Book Here
Book Description
This proceedings consists of selected papers presented at the International Conference on Computer Science and Technology (CST2016), which was successfully held in Shenzhen, China during January 8-10, 2016.CST2016 covered a wide range of fundamental studies, technical innovations and industrial applications in 7 areas, namely Computer Systems, Computer Network, Security, Databases and Information Systems, Artificial Intelligence and Multimedia, Theory and Software Engineering and Computer Applications.CST 2016 aims to provide a forum for researchers, engineers, and students in the area of computer science and technology. It features unique mixed various topics in computer science and technology including big data, system architecture, hardware and applications. CST 2016 attracted more than 300 submissions. Among them, only 142 papers were accepted in to the conference after a stringent peer review process.
Author: Patrick Lownds
Publisher: Packt Publishing Ltd
ISBN: 1785885340
Category : Computers
Languages : en
Pages : 524
Get Book Here
Book Description
Save time and resources by getting to know the best practices and intelligence from industry experts About This Book This book helps you gain a fresh perspective through a recipe-based approach on the new Microsoft Server 2016 Hyper-V Over 80 recipes to help you master the administrative tasks of Hyper-V and get to grips with advanced solutions and techniques for virtualization These hands-on advanced recipes will help you deploy, maintain, and upgrade Hyper-V virtual machines Who This Book Is For This book is for Hyper-V administrators who are looking to take advantage of all exciting new features that Microsoft Server 2016 Hyper-V has to offer. What You Will Learn Install and manage Hyper-V in Full, Server Core, and Nano Server Get to know how to migrate and upgrade physical and virtual machines Configure disks, network, memory, security, and auditing settings for virtual machines Take a deep dive into high availability and disaster recovery Save time and money by getting to grips with PowerShell automation Understand the new features around network and nested virtualization, distributed storage QoS, Hyper-V Replica, and much more Gain a full view of your virtual machines and host servers through monitoring, reporting, and troubleshooting tips In Detail Hyper-V is a Windows-based, very cost-effective virtualization solution with easy-to-use and well-known administrative consoles. With this book on your side you will master the worlds of Hyper-V deployment, migration, and management by learning tips, tricks, and best practices, especially when it comes to advanced-level tasks. You will learn how to quickly deploy and automate multiple VMs, and support Hyper-V clusters through different installation methods. You will learn the concepts efficiently with the help of up-to-date real-world examples and improve the scalability and efficiency of large-scale VM deployments with Nano Server. By the end of this book, you will be an ace Windows Server 2016 Hyper-V with the skills needed to administer and manage it effectively and survive in the brave new world of mobile-first, cloud-first. Further, take advantage of bonus appendix explaining Hyper-V and backup architecture and the difference between versions. Style and approach This advanced-level book provides step-by-step recipes on real-world examples so you can get practical, hands-on experience of the subjects.
Author: Patrik Andersson
Publisher: Frontiers Media SA
ISBN: 2889631613
Category :
Languages : en
Pages : 316
Get Book Here
Book Description
The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.
Author: Tai-He Fan
Publisher: Springer
ISBN: 3319462067
Category : Technology & Engineering
Languages : en
Pages : 654
Get Book Here
Book Description
This book is the proceedings of the Fourth International Conference on Quantitative Logic and Soft Computing (QLSC2016) held 14-17, October, 2016 in Zhejiang Sci-Tech University, Hangzhou, China. It includes 61 papers, of which 5 are plenary talks( 3 abstracts and 2 full length talks). QLSC2016 was the fourth in a series of conferences on Quantitative Logic and Soft Computing. This conference was a major symposium for scientists, engineers and practitioners to present their updated results, ideas, developments and applications in all areas of quantitative logic and soft computing. The book aims to strengthen relations between industry research laboratories and universities in fields such as quantitative logic and soft computing worldwide as follows: (1) Quantitative Logic and Uncertainty Logic; (2) Automata and Quantification of Software; (3) Fuzzy Connectives and Fuzzy Reasoning; (4) Fuzzy Logical Algebras; (5) Artificial Intelligence and Soft Computing; (6) Fuzzy Sets Theory and Applications.
Author: Fumito Ito
Publisher: Elsevier Health Sciences
ISBN: 0323549500
Category : Medical
Languages : en
Pages : 271
Get Book Here
Book Description
Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It's an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. - Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. - Helps you translate current research and literature into practical information for daily practice. - Presents information logically organized by disease site. - Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. - Consolidates today's available information on this timely topic into one convenient resource.
Author: Xuelei Ma
Publisher: Frontiers Media SA
ISBN: 2832509150
Category : Medical
Languages : en
Pages : 537
Get Book Here
Book Description
Author: Alison Taylor
Publisher: Frontiers Media SA
ISBN: 2832512771
Category : Medical
Languages : en
Pages : 254
Get Book Here
Book Description
Author: Alexandr V. Bazhin
Publisher: Frontiers Media SA
ISBN: 288945732X
Category :
Languages : en
Pages : 197
Get Book Here
Book Description
Author: Xuelei Ma
Publisher: Frontiers Media SA
ISBN: 283253015X
Category : Medical
Languages : en
Pages : 264
Get Book Here
Book Description
