Author: Laurens Holmes, Jr.
Publisher: Routledge
ISBN: 1498741207
Category : Medical
Languages : en
Pages : 288
Get Book Here
Book Description
The past three decades have witnessed modern advances in statistical modeling and evidence discovery in biomedical, clinical, and population-based research. With these advances come the challenges in accurate model stipulation and application of models in scientific evidence discovery Applied Biostatistical Principles and Concepts provides practical knowledge using biological and biochemical specimen/samples in order to understand health and disease processes at cellular, clinical, and population levels. Concepts and techniques provided will help researchers design and conduct studies, then translate data from bench to clinics in attempt to improve the health of patients and populations. This book is suitable for both clinicians and health or biological sciences students. It presents the reality in statistical modelling of health research data in a concise manner that will address the issue of "big data" type I error tolerance and probability value, effect size and confidence interval for precision, effect measure modification and interaction as well as confounders, thus allowing for more valid inferences and yielding results that are more reliable, valid and accurate.
Author: Laurens Holmes, Jr. and Franklin Opara
Publisher: Author House
ISBN: 1491843519
Category : Education
Languages : en
Pages : 393
Get Book Here
Book Description
Biostatistics deals with making sense of data. While statistical inference is essential in our application of the research findings to clinical decision-making regarding the care of our patients, statistical inference without clinical relevance or importance can be very misleading and even meaningless. This textbook has attempted to deemphasize p value in the interpretation of clinical and biomedical data by stressing the importance of confidence intervals, which allow for the quantification of evidence. For example, a large study due to a large sample size that minimizes variability may show a statistically significant difference while in reality the difference is too insignificant to warrant any clinical relevance. Covers these relevant topics in biostatistics: Design Process, Sampling & Reality in Statistical Modeling Basics of Biostatistical Reasoning & Inference Central Tendency Theorem & Measures of Dispersion Most commonly used & abused parametric test - t test Most commonly used & abused non-parametric test - chi squared statistic Sample size and power estimations Logistic/Binomial Regression Models - Binary Outcomes Time-to-Event Data - Survival Analysis & Count Data - Poisson Regression ANOVA, ANCOVA - Mixed Effects Model (Fixed and Random), RANOVA, GEE Simple & Multiple Linear Regression Models Correlation Analysis (Pearson & Spearman Rank) Clinical & Statistical Significance - p value as a function of sample size Clinical and biomedical researchers often ignore an important aspect of evidence discovery from their funded or unfunded projects. Since the attempt is to illustrate some sets of relationships from the data set, researchers often do not exercise substantial amount of time in assessing the reliability and validity of the data to be utilized in the analysis. However, the expected inference or the conclusion to be drawn is based on the analysis of the un-assessed data. Reality in statistical modeling of biomedical and clinical research data remains the focus of scientific evidence discovery, and this book. This text is written to highlight the importance of appropriate design prior to analysis by placing emphasis on subject selection and probability sample and the randomization process when applicable prior to the selection of the analytic tool. In addition, this book stresses the importance of biologic and clinical significance in the interpretation of study findings. The basis for statistical inference, implying the quantification of random error is random sample, which had been perpetually addressed in this book. When studies are conducted without a random sample, except when disease registries/databases or consecutive subjects are utilized, as often encountered in clinical and biomedical research, it is meaningless to report the findings with p value.
Author: Gerstman
Publisher: Jones & Bartlett Publishers
ISBN: 1284025470
Category : Education
Languages : en
Pages : 662
Get Book Here
Book Description
Basic Biostatistics is a concise, introductory text that covers biostatistical principles and focuses on the common types of data encountered in public health and biomedical fields. The text puts equal emphasis on exploratory and confirmatory statistical methods. Sampling, exploratory data analysis, estimation, hypothesis testing, and power and precision are covered through detailed, illustrative examples. The book is organized into three parts: Part I addresses basic concepts and techniques; Part II covers analytic techniques for quantitative response variables; and Part III covers techniques for categorical responses. The Second Edition offers many new exercises as well as an all new chapter on "Poisson Random Variables and the Analysis of Rates." With language, examples, and exercises that are accessible to students with modest mathematical backgrounds, this is the perfect introductory biostatistics text for undergraduates and graduates in various fields of public health. Features: Illustrative, relevant examples and exercises incorporated throughout the book. Answers to odd-numbered exercises provided in the back of the book. (Instructors may requests answers to even-numbered exercises from the publisher. Chapters are intentionally brief and limited in scope to allow for flexibility in the order of coverage. Equal attention is given to manual calculations as well as the use of statistical software such as StaTable, SPSS, and WinPepi. Comprehensive Companion Website with Student and Instructor's Resources.
Author: Sylvia Wassertheil-Smoller
Publisher: Springer Science & Business Media
ISBN: 0387218297
Category : Medical
Languages : en
Pages : 249
Get Book Here
Book Description
For the new edition of Biostatistics and Epidemiology, Dr. Wassertheil-Smoller has included several new chapters (genetic statistics, molecular epidemiology, scientific integrity and research ethics) and a new appendix on the basic concepts of genetics and a glossary of genetic terminology. She has also expanded the coverage of multi-center trials (an important aspect of implementation of the standards of evidence-based medicine), controversies in screening for prostate, colon, breast, and other cancers.
Author: Laurens Holmes Jr.
Publisher: AuthorHouse
ISBN: 1491810025
Category : Education
Languages : en
Pages : 338
Get Book Here
Book Description
This textbook describes the basics of research in medical, clinical, and biomedical settings as well as the concepts and application of epidemiologic designs in research conduct. Design transcends statistical techniques, and no matter how sophisticated a statistical modeling, errors of design/sampling cannot be corrected. The authors of this textbook have presented a complex field in a very simplified and reader-friendly manner with the intent that such presentation will facilitate the understanding of design process and epidemiologic thinking in clinical and biomedical research. Covers these relevant topics in epidemiology: Case-Cohort Design Prospective Case-Control Quantitative Evidence Synthesis (QES) Instant Cohort Design & Case-Crossover Design Effect Modification & Interaction Epidemiologic Tree - Molecular Epidemiology & Health Disparities Epidemiologic Challenge Big Data, mHealth, Social Media 3 Ts - Team Science, Transdisciplinary Research, Translational Research Bias, Random error, Confounding Systems Science & Evidence Discovery Research is presented as an exercise around measurement, with measurement error inevitable in its conducthence the inherent uncertainties of all findings in clinical and biomedical research. Concise Epidemiologic Principles and Concepts covers research conceptualization, namely research objectives, questions, hypothesis, design, implementation, data collection, analysis, results, and interpretation. While the primary focus of epidemiology is to assess the relationship between exposure (risk or predisposing factor) and outcome (disease or health-related event), causal association is presented in a simplified manner, including the role of quantitative evidence synthesis (meta-analysis) in causal inference. Epidemiology has evolved over the past three decades resulting in several fields being developed. This text presents in brief the perspectives and future of epidemiology in the era of the molecular basis of medicine. With molecular epidemiology, we are better equipped with tools to identify molecular biologic indicators of risk as well as biologic alterations in the early stages of disease.
Author: Chap T. Le
Publisher: John Wiley & Sons
ISBN: 111821062X
Category : Medical
Languages : en
Pages : 336
Get Book Here
Book Description
Like its two successful previous editions, Health & Numbers: A Problems-Based Introduction to Biostatistics, Third Edition, is the only fully problems-based introduction to biostatistics and offers a concise introduction to basic statistical concepts and reasoning at a level suitable for a broad spectrum of students and professionals in medicine and the allied health fields. This book has always been meant for use by advanced students who have not previously had an introductory biostatistics course - material often presented in a one-semester course - or by busy professionals who need to learn the basics of biostatistics. This user-friendly resource features over 200 real-life examples and real data to discuss and teach fundamental statistical methods. The new edition offers even more exercises than the second edition, and features enhanced Microsoft Excel and SAS samples and examples. Health & Numbers, Third Edition, truly strikes a balance between principles and methods of calculation that is particularly useful for students in medicine and health-related fields who need to know biostatistics.
Author: Marcello Pagano
Publisher: Cengage Learning
ISBN: 9780534140694
Category : Biometry
Languages : en
Pages : 0
Get Book Here
Book Description
This introduction to biostatistics offers health science studentsQwith limited math and statistics backgroundsQa conceptually-based introduction to statistical procedures that will prepare them to conduct or evaluate research in biological and health sciences. Enthusiasm for the material will quickly spread to the reader from the author. The author's appealing writing style makes users of the text Rforget it is math.S Students are encouraged to use common sense rather than rigorous theory to gain an understanding of statistics..The authors rely heavily on graphics to illustrate material and incorporate the use of computers to facilitate doing computations so students can concentrate on concepts. Quantitative principles discussed include descriptive statistics, life tables, probability, hypothesis testing, parameter estimation, regression (linear and logistic) correlation, survival analysis, analysis of variance, and more.
Author: Felix Abramovich
Publisher: CRC Press
ISBN: 1000784746
Category : Mathematics
Languages : en
Pages : 237
Get Book Here
Book Description
Designed for a one-semester advanced undergraduate or graduate statistical theory course, Statistical Theory: A Concise Introduction, Second Edition clearly explains the underlying ideas, mathematics, and principles of major statistical concepts, including parameter estimation, confidence intervals, hypothesis testing, asymptotic analysis, Bayesian inference, linear models, nonparametric statistics, and elements of decision theory. It introduces these topics on a clear intuitive level using illustrative examples in addition to the formal definitions, theorems, and proofs. Based on the authors’ lecture notes, the book is self-contained, which maintains a proper balance between the clarity and rigor of exposition. In a few cases, the authors present a "sketched" version of a proof, explaining its main ideas rather than giving detailed technical mathematical and probabilistic arguments. Features: Second edition has been updated with a new chapter on Nonparametric Estimation; a significant update to the chapter on Statistical Decision Theory; and other updates throughout No requirement for heavy calculus, and simple questions throughout the text help students check their understanding of the material Each chapter also includes a set of exercises that range in level of difficulty Self-contained, and can be used by the students to understand the theory Chapters and sections marked by asterisks contain more advanced topics and may be omitted Special chapters on linear models and nonparametric statistics show how the main theoretical concepts can be applied to well-known and frequently used statistical tools The primary audience for the book is students who want to understand the theoretical basis of mathematical statistics—either advanced undergraduate or graduate students. It will also be an excellent reference for researchers from statistics and other quantitative disciplines.
Author: Abhaya Indrayan
Publisher: CRC Press
ISBN: 1482243881
Category : Medical
Languages : en
Pages : 729
Get Book Here
Book Description
Concise Encyclopedia of Biostatistics for Medical Professionals focuses on conceptual knowledge and practical advice rather than mathematical details, enhancing its usefulness as a reference for medical professionals. The book defines and describes nearly 1000 commonly and not so commonly used biostatistical terms and methods arranged in alphabetical order. These range from simple terms, such as mean and median to advanced terms such as multilevel models and generalized estimating equations. Synonyms or alternative phrases for each topic covered are listed with a reference to the topic.
Author: Carol K. Redmond
Publisher: John Wiley & Sons
ISBN: 0471822116
Category : Medical
Languages : en
Pages : 530
Get Book Here
Book Description
"Biostatistics in Clinical Trials" gehört zur Reihe 'Wiley Reference Series in Biostatistics' und basiert auf der renommierten 'Encyclopedia of Biostatistics'. Dieser Band enthält 25% neues Material, umfassend aktualisierte Artikel und Verweise aus der Enzyklopädie sowie prägnante Definitionen und Einführungen in zahlreiche Grundlagen aus der aktuellen Literatur. Darüber hinaus wird eine Reihe neuer Themen behandelt, wie z.B. Bayesche Methoden, ethische Fragen und die Nutzen-Risiko-Bewertung. Durch umfangreiche Querverweise findet der Leser rasch Definitionen und verwandte Konzepte .
