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Author: Carole Sauer
Publisher:
ISBN:
Category :
Languages : fr
Pages : 216
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Book Description
Les implants médicaux contrôlant l’activité ou les pathologies cérébrales connaissent un véritable essor. En effet, ces microsystèmes étant de très petites dimensions, ils peuvent être intégrés dans le cerveau tout en pouvant contenir de nombreux capteurs sur un même dispositif. Cependant, ces implants médicaux doivent être stériles, biocompatibles et non toxique in vivo afin d’éviter tout rejet ou complication tels que les infections ou les inflammations. L’oxyde d’indium dopé à l’étain (ITO) est un matériau de choix pour ces dispositifs médicaux, car il est biocompatible et possède des propriétés de conductivité. De plus, le greffage en sa surface de molécules organiques telles que les composés organophosphorés permet de moduler son activité. Ainsi, la chimie click, a été sélectionnée pour la synthèse des composés organophosphorés à greffer, et notamment la synthèse par chimie click thiol-ène. Nous avons mis au point des conditions permettant, dans des temps courts, sous irradiation dans l’eau ou l’éthanol de coupler divers thiols avec des d’alcénylphosphonates. Ces conditions, jusqu’alors jamais appliquées pour la fonctionnalisation de l’ITO, nous ont permis d'introduire efficacement une fonction acide carboxylique sur sa surface. Parallèlement, la nécessité d’obtenir de façon rapide et efficace des fonctions carbonylées en surface, nous a conduit à envisager la synthèse de méthyle cétones par hydratation d’alcynylphosphonates catalysée par des complexes d’or, sous irradiation micro-ondes en milieu aqueux. Les phosphonates fonctionnalisés selon ces deux processus ont ensuite été greffés sur l’ITO dans des conditions vertes, afin d’introduire diverses fonctions
Author: Carole Sauer
Publisher:
ISBN:
Category :
Languages : fr
Pages : 216
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Book Description
Les implants médicaux contrôlant l’activité ou les pathologies cérébrales connaissent un véritable essor. En effet, ces microsystèmes étant de très petites dimensions, ils peuvent être intégrés dans le cerveau tout en pouvant contenir de nombreux capteurs sur un même dispositif. Cependant, ces implants médicaux doivent être stériles, biocompatibles et non toxique in vivo afin d’éviter tout rejet ou complication tels que les infections ou les inflammations. L’oxyde d’indium dopé à l’étain (ITO) est un matériau de choix pour ces dispositifs médicaux, car il est biocompatible et possède des propriétés de conductivité. De plus, le greffage en sa surface de molécules organiques telles que les composés organophosphorés permet de moduler son activité. Ainsi, la chimie click, a été sélectionnée pour la synthèse des composés organophosphorés à greffer, et notamment la synthèse par chimie click thiol-ène. Nous avons mis au point des conditions permettant, dans des temps courts, sous irradiation dans l’eau ou l’éthanol de coupler divers thiols avec des d’alcénylphosphonates. Ces conditions, jusqu’alors jamais appliquées pour la fonctionnalisation de l’ITO, nous ont permis d'introduire efficacement une fonction acide carboxylique sur sa surface. Parallèlement, la nécessité d’obtenir de façon rapide et efficace des fonctions carbonylées en surface, nous a conduit à envisager la synthèse de méthyle cétones par hydratation d’alcynylphosphonates catalysée par des complexes d’or, sous irradiation micro-ondes en milieu aqueux. Les phosphonates fonctionnalisés selon ces deux processus ont ensuite été greffés sur l’ITO dans des conditions vertes, afin d’introduire diverses fonctions
Author: Ahmed Belasri
Publisher: Springer Nature
ISBN: 9811554447
Category : Technology & Engineering
Languages : en
Pages : 659
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Book Description
This book highlights peer reviewed articles from the 1st International Conference on Renewable Energy and Energy Conversion, ICREEC 2019, held at Oran in Algeria. It presents recent advances, brings together researchers and professionals in the area and presents a platform to exchange ideas and establish opportunities for a sustainable future. Topics covered in this proceedings, but not limited to, are photovoltaic systems, bioenergy, laser and plasma technology, fluid and flow for energy, software for energy and impact of energy on the environment.
Author: Abdul W. Basit
Publisher: Springer
ISBN: 3319907557
Category : Medical
Languages : en
Pages : 246
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Book Description
3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use. Potential applications range from pre-clinical drug development and dosage form design through to the fabrication of functionalised implants and regenerative medicine. Within clinical pharmacy practice, printing technologies may finally lead to the concept of personalised medicines becoming a reality. This volume aims to be the definitive resource for anyone thinking of developing or using 3D printing technologies in the pharmaceutical sector, with a strong focus on the translation of printing technologies to a clinical setting. This text brings together leading experts to provide extensive information on an array of 3D printing techniques, reviewing the current printing technologies in the pharmaceutical manufacturing supply chain, in particular, highlighting the state-of-the-art applications in medicine and discussing modern drug product manufacture from a regulatory perspective. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in pharmaceuticals. Abdul W. Basit is Professor of Pharmaceutics at the UCL School of Pharmacy, University College London. Abdul’s research sits at the interface between pharmaceutical science and gastroenterology, forging links between basic science and clinical outcomes. He leads a large and multidisciplinary research group, and the goal of his work is to further the understanding of gastrointestinal physiology by fundamental research. So far, this knowledge has been translated into the design of new technologies and improved disease treatments, many of which are currently in late-stage clinical trials. He has published over 350 papers, book chapters and abstracts and delivered more than 250 invited research presentations. Abdul is also a serial entrepreneur and has filed 25 patents and founded 3 pharmaceutical companies (Kuecept, Intract Pharma, FabRx). Abdul is a frequent speaker at international conferences, serves as a consultant to many pharmaceutical companies and is on the advisory boards of scientific journals, healthcare organisations and charitable bodies. He is the European Editor of the International Journal of Pharmaceutics. Abdul was the recipient of the Young Investigator Award in Pharmaceutics and Pharmaceutical Technology from the American Association of Pharmaceutical Scientists (AAPS) and is the only non-North American scientist to receive this award. He was also the recipient of the Academy of Pharmaceutical Sciences (APS) award. Simon Gaisford holds a Chair in Pharmaceutics and is Head of the Department of Pharmaceutics at the UCL School of Pharmacy, University College London. He has published 110 papers, 8 book chapters and 4 authored books. His research is focused on novel technologies for manufacturing medicines, particularly using ink-jet printing and 3D printing, and he is an expert in the physico-chemical characterisation of compounds and formulations with thermal methods and calorimetry.
Author: Stuart Hill
Publisher: Birkhäuser
ISBN: 3034863101
Category : Science
Languages : en
Pages : 364
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Book Description
Author: Kevin M. Cleaver
Publisher: World Bank Publications
ISBN: 9780821322567
Category : Nature
Languages : en
Pages : 372
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Book Description
This volume brings together selected papers presented and discussed at the Conference on Conservation of West and Central African Rainforests, held in Abidjan, November 5-9, 1990.
Author: Chitra Banerjee Divakaruni
Publisher: Simon and Schuster
ISBN: 1476792011
Category : Fiction
Languages : en
Pages : 240
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Book Description
"A new novel from the author of Oleander Girl, a novel in stories, built around crucial moments in the lives of 3 generations of women in an Indian/Indian-American Family"--
Author:
Publisher: UNICEF
ISBN: 9280643762
Category : Business & Economics
Languages : en
Pages : 244
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Book Description
This Child-Friendly Schools (CFS) Manual was developed during three-and-a-half years of continuous work, involving the United Nations Children's Fund education staff and specialists from partner agencies working on quality education. It benefits from fieldwork in 155 countries and territories, evaluations carried out by the Regional Offices and desk reviews conducted by headquarters in New York. The manual is a part of a total resource package that includes an e-learning package for capacity-building in the use of CFS models and a collection of field case studies to illustrate the state of the art in child-friendly schools in a variety of settings.
Author: Loïc J. D. Wacquant
Publisher: U of Minnesota Press
ISBN: 0816639000
Category : Social Science
Languages : en
Pages : 227
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Book Description
In this title, the author examines how penal policies emanating from the United States have spread thoughout the world. The author argues that the policies have their roots in a network of Reagan-era conservative think tanks, which used them as weapons in their crusade to dismantle the welfare state and, in effect, criminalise poverty.
Author: Food and Agriculture Organization of the United Nations
Publisher: Food & Agriculture Organization of the UN (FAO)
ISBN:
Category : Architecture
Languages : en
Pages : 116
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Book Description
The Second Global Plan of Action addresses new challenges, such as climate change and food insecurity, as well as novel opportunities, including information, communication and molecular methodologies. It contains 18 priority activities organized in four main groups: In situ conservation and management; Ex situ conservation; Sustainable use; and Building sustainable institutional and human capacities.
Author: Kaisa Kaukiainen
Publisher:
ISBN: 9789523590144
Category :
Languages : en
Pages : 544
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Book Description
The essays in this edited volume, written in English and French, tackle the intriguing problems of fear and safety by analysing their various meanings and manifestations in literature and other narrative media. The articles bring forth new, cross-cultural interpretations on fear and safety through examining what kinds of genre-specific means of world-making narratives use to express these two affectivities. The articles also show how important it is to study these themes in order to understand challenges in times of global threats, such as the climate crisis, and - to imagine a better future. The main themes of the book are approached from various theoretical perspectives as related to their literary and cultural representations. Recent trends in research, such as affect and risk theory, serve as the basis for the discussion. Many of the articles in the volume discuss apocalyptic and dystopian narratives that currently permeate the entire cultural landscape. Dystopian narratives do not only deal with future threats, such as totalitarianism, technocracy, or environmental disasters, but also suggest alternative ways of being and new hopes in the form of political resistance. The articles in the volume also draw from disciplines such as gender studies and trauma studies to examine the threats posed by collective fears and aggression on individuals' lives and propose ways of coping with fear. These themes are addressed also in articles analysing new adaptations of old myths that retell stories of the past.
