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Author: Andrej Yu. Yakovlev
Publisher: Springer Science & Business Media
ISBN: 3642517161
Category : Mathematics
Languages : en
Pages : 135
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Book Description
This research monograph demonstrates the possible ways of using stochastic simulation for exploring cell kinetics, emphasising the effects of cell radiobiology. In vitro kinetics of normal and irradiated cells is the main subject, but some approaches to the simulation of controlled cell systems are considered as well: the epithelium of the small intestine in mice taken as a case in point. Of particular interest is the evaluation of simulation modelling as a tool for gaining insight into biological processes and hence the new inferences from concrete experimental data, concerning regularities in cell population response to irradiation. The book is intended to stimulate interest among computer science specialists in developing new, more efficient means for the simulation of cell systems and to help radiobiologists in interpreting the experimental data. The reader is expected to be acquainted with fundamentals of the theory of probability and stochastic processes. Applications are addressed to a biologically educated reader.
Author: Andrej Yu. Yakovlev
Publisher: Springer Science & Business Media
ISBN: 3642517161
Category : Mathematics
Languages : en
Pages : 135
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Book Description
This research monograph demonstrates the possible ways of using stochastic simulation for exploring cell kinetics, emphasising the effects of cell radiobiology. In vitro kinetics of normal and irradiated cells is the main subject, but some approaches to the simulation of controlled cell systems are considered as well: the epithelium of the small intestine in mice taken as a case in point. Of particular interest is the evaluation of simulation modelling as a tool for gaining insight into biological processes and hence the new inferences from concrete experimental data, concerning regularities in cell population response to irradiation. The book is intended to stimulate interest among computer science specialists in developing new, more efficient means for the simulation of cell systems and to help radiobiologists in interpreting the experimental data. The reader is expected to be acquainted with fundamentals of the theory of probability and stochastic processes. Applications are addressed to a biologically educated reader.
Author: Matesh N. Varma
Publisher: Springer Science & Business Media
ISBN: 1475797885
Category : Science
Languages : en
Pages : 262
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Book Description
The Office of Health and Environmental Research (OHER) has supported and continues to support development of computational approaches in biology and medicine. OHER's Radiological and Chemical Physics Program initiated development of computational approaches to determine the effects produced by radiation of different quality (such as high energy electrons, protons, helium and other heavy ions, etc. ) in a variety of materials of biological interest-such as water, polymers and DNA; these include molecular excitations and sub-excitations and the production of ionization and their spatial and temporal distribution. In the past several years, significant advances have been made in computational methods for this purpose. In particular, codes based on Monte Carlo techniques have ·been developed that provide a realistic description of track-structure produced by charged particles. In addition, the codes have become sufficiently sophisticated so that it is now possible to calculate the spatial and temporal distribution of energy deposition patterns in small volumes of subnanometer and nanometer dimensions. These dimensions or resolution levels are relevant for our understanding of mechanisms at the molecular level by which radiations affect biological systems. Since the Monte Carlo track structure codes for use in radiation chemistry and radiation biology are still in the developmental stage, a number of investigators have been exploring different strategies for improving these codes.
Author: T. G. Hennessy
Publisher: Elsevier
ISBN: 148322404X
Category : Science
Languages : en
Pages : 223
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Book Description
Proceedings of a Conference on Radiobiology at the Intra-Cellular Level provides the papers presented during the first U.C.L.A. Conference on Radiobiology, held at Catalina Island in September 1957. The compendium is comprised of research papers from a diverse group of scientists that explore the phenomena which take place in irradiated cells. The topics covered during the meeting include the radio sensitivity of the model cell; the chemical action of ionizing radiations and radiobiological effects; the sensitivity of different cells in the same organism; and the interactions between cells and tissues following radiation. Radiobiologists, cytologists, and biophysicists will find the book very insightful.
Author: J. Dutreix
Publisher: CRC Press
ISBN: 9780850667455
Category : Medical
Languages : en
Pages : 618
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Book Description
This textbook covers all aspects of radiation, radiotherapy and their effects. The book, initially published in France, has been updated and expanded in this English version. It includes a thorough discussion of recent advances, such as a better understanding of the molecular basis of cellular effects and cell radiosensitivity.There is a study of the mechanmism by which dose and overall duration of radiotherapy can introoduce differential effects between normal and neoplastic tissues and recent data on radiocarcinogenesis in man and experimental animals is provided.
Author: Andrej Yu. Yakovlev
Publisher: Springer Science & Business Media
ISBN: 3642487025
Category : Mathematics
Languages : en
Pages : 224
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Book Description
A mathematician who has taken the romantic decision to devote himself to biology will doubtlessly look upon cell kinetics as the most simple and natural field of application for his knowledge and skills. Indeed, the thesaurus he is to master is not so complicated as, say, in molecular biology, the structural elements of the system, i. e. ceils, have been segregated by Nature itself, simple considerations of balance may be used for deducing basic equations, and numerous analogies in other areas of science also superficial add to one"s confidence. Generally speaking, this number of impression is correct, as evidenced by the very great theoretical studies on population kinetics, unmatched in other branches of mathematical biology. This, however, does not mean that mathematical theory of cell systems has traversed in its development a pathway free of difficulties or errors. The seeming ease of formalizing the phenomena of cell kinetics not infrequently led to the appearance of mathematical models lacking in adequacy or effectiveness from the viewpoint of applications. As in any other domain of science, mathematical theory of cell systems has its own intrinsic logic of development which, however, depends in large measure on the progress in experimental biology. Thus, during a fairly long period running into decades activities in that sphere were centered on devising its own specific approaches necessitated by new objectives in the experimental in vivo and in vitro investigation of cell population kinetics in different tissues.
Author: O Arino
Publisher: World Scientific
ISBN: 981454597X
Category : Mathematics
Languages : en
Pages : 910
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Book Description
This is a collection of refereed papers presented at the 4th International Conference on Mathematical Population Dynamics. The selection of papers and their organization were made by the following persons: O Arino, D Axelrod, V Capasso, W Fitzgibbon, P Jagers, M Kimmel, D Kirschner, C Mode, B Novak, R Sachs, W Stephan, A Swierniak and H Thieme.It features some of the new trends in cell and human population dynamics. The main link between the two traits is that human populations of concern here are essentially those subject to cell diseases, either the processes of anarchic proliferation or those by which some cell lines are killed by an infectious agent.The volume is divided into 3 main parts. Each part is subdivided into chapters, each chapter concentrating on a specific aspect. Each aspect is illustrated by one or several examples, developed in sections contributed by several authors. A detailed introduction for each part will enable the reader to refer to chapters of interest. An index and a bibliography for each part is also included for easy reference.This book will be useful for those interested in the subject matter.
Author: A.Y. Yakovlev
Publisher: CRC Press
ISBN: 1000142396
Category : Mathematics
Languages : en
Pages : 146
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Book Description
Biomathematical Problems in Optimization of Cancer Radiotherapy provides insight into the role of cell population heterogeneity in the optimal control of fractionated irradiation of tumors. The book emphasizes the mathematical modeling aspect of the problem and presents the state of the art in the stochastic description of irradiated cell survival. Some of the results are of general theoretical interest and can be applied to other areas of optimal control methodology. Detailed explanations of all mathematical statements are provided throughout the text. The book is excellent for biomathematicians, radiotherapists, oncologists, health physicists, and other researchers and students interested in the topic.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 556
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Book Description
Author: Eric J. Hall
Publisher: Lippincott Williams & Wilkins
ISBN: 1451154186
Category : Medical
Languages : en
Pages : 908
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Book Description
In print since 1972, this seventh edition of Radiobiology for the Radiologist is the most extensively revised to date. It consists of two sections, one for those studying or practicing diagnostic radiolo, nuclear medicine and radiation oncology; the other for those engaged in the study or clinical practice of radiation oncology--a new chapter, on radiologic terrorism, is specifically for those in the radiation sciences who would manage exposed individuals in the event of a terrorist event. The 17 chapters in Section I represent a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA. The 11 chapters in Section II address more in-depth topics in radiation oncology, such as cancer biology, retreatment after radiotherapy, chemotherapeutic agents and hyperthermia. Now in full color, this lavishly illustrated new edition is replete with tables and figures that underscore essential concepts. Each chapter concludes with a "summary of pertinent conclusions" to facilitate quick review and help readers retain important information.
Author: Tikvah Alper
Publisher:
ISBN: 9780521224116
Category : Science
Languages : en
Pages : 320
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Book Description
