Computer Assisted Optimization of Cardiac Resynchronization Therapy PDF Download
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Author: Raz Miri
Publisher: KIT Scientific Publishing
ISBN: 3866443609
Category : Technology (General)
Languages : en
Pages : 308
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Book Description
The efficacy of cardiac resynchronization therapy (CRT) through biventricular pacing (BVP) has been demonstrated by numerous studies in patients suffering from congestive heart failure. In order to achieve a guideline for optimal treatment with BVP devices, an automated non-invasive strategy based on an electrophysiological computer model of the heart is presented. The presented research investigates an off-line optimization algorithm based on different electrode positioning and timing delays.
Author: Raz Miri
Publisher: KIT Scientific Publishing
ISBN: 3866443609
Category : Technology (General)
Languages : en
Pages : 308
Get Book Here
Book Description
The efficacy of cardiac resynchronization therapy (CRT) through biventricular pacing (BVP) has been demonstrated by numerous studies in patients suffering from congestive heart failure. In order to achieve a guideline for optimal treatment with BVP devices, an automated non-invasive strategy based on an electrophysiological computer model of the heart is presented. The presented research investigates an off-line optimization algorithm based on different electrode positioning and timing delays.
Author:
Publisher:
ISBN: 9781000011296
Category :
Languages : en
Pages : 0
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Book Description
The efficacy of cardiac resynchronization therapy (CRT) through biventricular pacing (BVP) has been demonstrated by numerous studies in patients suffering from congestive heart failure. In order to achieve a guideline for optimal treatment with BVP devices, an automated non-invasive strategy based on an electrophysiological computer model of the heart is presented. The presented research investigates an off-line optimization algorithm based on different electrode positioning and timing delays.
Author: Baas, Tobias
Publisher: KIT Scientific Publishing
ISBN: 3866448821
Category : Technology & Engineering
Languages : en
Pages : 260
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Book Description
ECG recordings provide diagnostic relevant information on the de- and repolarisation sequences of the heart. A modification of the repolarisation sequence is assumed to cause Torsades de Pointes. Especially drug induced effects on the repolarisation processes are in focus, since some non-cardiac drugs have been associated with sudden cardiac death in the 1990s.The analysis of the ventricular repolarisation using a set of parameters depicting the morphology of the T-wave is introduced in this work. Therefore, new methods of fully automatic patient-specific QRS detection, beat classification and precise T-wave delineation are presented. Using these methods, medical studies are investigated regarding the modification of the T-wave by different compounds. Also the impact of the heart rate on the morphology of the T-wave is part of this research.The reliable identification of ventricular ectopic beats allows an analysis of the influence of these beats on subsequent heart beats. It turned out that the morphology of subsequent heart beats can significantly be changed. This might give new information on the proarrythmical risk of ventricular ectopic beats.
Author: Mathias Wilhelms
Publisher: KIT Scientific Publishing
ISBN: 3731500450
Category : Technology & Engineering
Languages : en
Pages : 206
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Book Description
Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
Author: Pollnow, Stefan
Publisher: KIT Scientific Publishing
ISBN: 3731508869
Category : Technology (General)
Languages : en
Pages : 296
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Book Description
Catheter ablation is a major treatment for atrial tachycardias. Hereby, the precise monitoring of the lesion formation is an important success factor. This book presents computational, wet-lab, and clinical studies with the aim of evaluating the signal characteristics of the intracardiac electrograms (IEGMs) recorded around ablation lesions from different perspectives. The detailed analysis of the IEGMs can optimize the description of durable and complex lesions during the ablation procedure.
Author: Oussama Jarrousse
Publisher: KIT Scientific Publishing
ISBN: 3866447426
Category : Technology & Engineering
Languages : en
Pages : 244
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Book Description
Mass-spring systems are considered the simplest and most intuitive of all deformable models. They are computationally efficient, and can handle large deformations with ease. But they suffer several intrinsic limitations. In this book a modified mass-spring system for physically based deformation modeling that addresses the limitations and solves them elegantly is presented. Several implementations in modeling breast mechanics, heart mechanics and for elastic images registration are presented.
Author: Tobias Voigt
Publisher: KIT Scientific Publishing
ISBN: 3866445989
Category : Technology & Engineering
Languages : en
Pages : 168
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Book Description
This work presents three new quantitative methods for magnetic resonance imaging. A method for simultaneous mapping of B1 and T1 (MTM) is developed and validated. Electric Properties Tomography (EPT), a method for quantitative imaging of dielectric properties of tissue, is presented. Based on EPT, separate (phase-based) conductivity and (amplitude-based) permittivity measurements are introduced. Finally, a B1-based method for patient-specific local SAR measurements is presented.
Author: Keller, Matthias
Publisher: KIT Scientific Publishing
ISBN: 3731502283
Category : Technology & Engineering
Languages : en
Pages : 264
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Book Description
This work presents methods to advance electrophysiological simulations of intracardiac electrograms (IEGM). An experimental setup is introduced, which combines electrical measurements of extracellular potentials with a method for optical acquisition of the transmembrane voltage in-vitro. Thereby, intracardiac electrograms can be recorded under defined conditions. Using experimental and clinical signals, detailed simulations of IEGMs are parametrized, which can support clinical diagnosis.
Author: Sánchez Arciniegas, Jorge Patricio
Publisher: KIT Scientific Publishing
ISBN: 3731511703
Category : Medical
Languages : en
Pages : 162
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Book Description
The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.
Author: Martin Wolfgang Krüger
Publisher: KIT Scientific Publishing
ISBN: 3866449488
Category : Technology & Engineering
Languages : en
Pages : 320
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Book Description
This book targets three fields of computational multi-scale cardiac modeling. First, advanced models of the cellular atrial electrophysiology and fiber orientation are introduced. Second, novel methods to create patient-specific models of the atria are described. Third, applications of personalized models in basic research and clinical practice are presented. The results mark an important step towards the patient-specific model-based atrial fibrillation diagnosis, understanding and treatment.
