Computer-Aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates PDF Download
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Author: Jujjvarapu Satya Eswari
Publisher: CRC Press
ISBN: 1351018299
Category : Medical
Languages : en
Pages : 147
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Book Description
Increase in antibiotic resistance has forced researchers to develop new drugs against microorganisms. Lipopeptides are produced as secondary metabolites by some microorganisms. Computer-aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates provides the identification of novel ligands for different antimicrobial lipopeptides. Along with identification, it also provides some of the in silico drug design processes, namely homology modelling, molecular docking, QSAR studies, drug ADMET studies and pharmacophore studies to check the ligand-lipopeptide interaction. Some lipopeptides have shown anti-cancerous properties too, and this book discusses the required templates to design new drugs using computational techniques. Key Features: Focuses on the use lipopeptides as new antimicrobial compounds Presents the basics of in silico modelling for design and development of new drug molecules, and is therefore of interest to beginners in the field Provides a step-by-step process for identification of drug molecules and testing its efficacy in silico Couples with courses on patents and intellectual property rights
Author: Jujjvarapu Satya Eswari
Publisher: CRC Press
ISBN: 1351018299
Category : Medical
Languages : en
Pages : 147
Get Book Here
Book Description
Increase in antibiotic resistance has forced researchers to develop new drugs against microorganisms. Lipopeptides are produced as secondary metabolites by some microorganisms. Computer-aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates provides the identification of novel ligands for different antimicrobial lipopeptides. Along with identification, it also provides some of the in silico drug design processes, namely homology modelling, molecular docking, QSAR studies, drug ADMET studies and pharmacophore studies to check the ligand-lipopeptide interaction. Some lipopeptides have shown anti-cancerous properties too, and this book discusses the required templates to design new drugs using computational techniques. Key Features: Focuses on the use lipopeptides as new antimicrobial compounds Presents the basics of in silico modelling for design and development of new drug molecules, and is therefore of interest to beginners in the field Provides a step-by-step process for identification of drug molecules and testing its efficacy in silico Couples with courses on patents and intellectual property rights
Author: R.Z. Sayyed
Publisher: CRC Press
ISBN: 1000415651
Category : Medical
Languages : en
Pages : 326
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Book Description
Biosurfactants are the surface-active biomolecules produced by microorganisms. Biosurfactants have gained commercial significance due to their unique properties, such as high surface activity, high specificity, low toxicity, tolerance to pH, temperature and ionic strength, biodegradability, excellent emulsifying and demulsifying ability, antimicrobial activity, ability to work under extreme conditions, and relative ease of preparation. Biosurfactants are used in several industries, including organic chemicals, petroleum, petrochemicals, mining, metallurgy (mainly bioleaching), agrochemicals, fertilizers, foods, beverages, cosmetics, pharmaceuticals and many others. The aim of this book is to highlight key aspects from basics to advanced concepts, classifications, production and applications in various fields such as agriculture, health, bioremediation, industries, pharmaceutical, oil recovery, environment, and nanotechnology. It also serves as an excellent and expansive literature on fermentation, recovery, genomics, and metagenomics of biosurfactant production. The book focuses on the biosurfactant production from bacteria, the diversity of biosurfactant producing bacteria, and industrial need of biosurfactant.
Author: Provash Chandra Sadhukhan
Publisher: Springer Nature
ISBN: 9811534535
Category : Medical
Languages : en
Pages : 117
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Book Description
This book compiles selected articles presented at the International Conference on Biotechnology & Biological Sciences, BIOSPECTRUM 2017, organized by the Department of Biotechnology, University of Engineering & Management, Kolkata. Focusing on biotechnology-based analysis and intervention to address certain human diseases, the book includes a holistic discourse on disease profiling, molecular level analysis of diseases, and non-invasive medical interventions. It features articles on non-invasive treatment of iron deficiency anemia with iron nanoparticles; novel diagnosis methods based on microarray data; analysis using machine learning techniques like artificial neural network for early detection and treatment of cancer; and drug discovery for preventing the growth of human leukemic cells. Further, the book sheds light on in silico drug design using lipopeptides, and identifying the binding sites for their corresponding ligands. Presenting the concepts of the design of potent and safe antimicrobial compounds to fight multi drug resistant pathogens, it also includes interesting reviews on the design and development of various non-invasive methods, such as multi NIR wavelength probes to identify the risk areas in the diabetic foot at an early stage; and a low-cost cochlear implant prototype designed and developed from commercial off the-shelf components to empower the hearing impaired. The book appeals to students, academics and researchers in a wide range of subject areas, including biotechnology, life sciences, medicine and cancer research.
Author: Fei Ye
Publisher: Frontiers Media SA
ISBN: 2889767841
Category : Science
Languages : en
Pages : 205
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Book Description
Author: Carolina Otero
Publisher: Frontiers Media SA
ISBN: 2889718727
Category : Science
Languages : en
Pages : 67
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Book Description
Author: Zhengqing Fu
Publisher: Frontiers Media SA
ISBN: 2889632938
Category :
Languages : en
Pages : 326
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Book Description
Plants constantly face many kinds of abiotic and biotic stresses. One of the major threats is from many plant fungal, oomycete, viral, bacterial and nematode pathogens. Plant diseases caused by these pathogens reduce crop yield by 10-15% worldwide every year. Throughout the human history, plant diseases are responsible for many famines including the infamous Irish Potato Famine. Besides the negative impact on the yield, the quality of the infected crop will be adversely affected and the toxins produced by plant pathogens pose threat to human health. During the co-evolution between plants and pathogens, plants developed elegant defense system against pathogen infection and plant pathogens deploy a variety of strategies to suppress plant innate immunity. A deeper understanding the molecular mechanisms on the activation of plant defense in plants and suppression of plant defense by plant pathogens will be crucial to develop effective ways to minimize the detrimental effects from plant diseases on human beings. This Research Topic aims to increase our understanding on the molecular interactions between plants and pathogens.
Author: Richard M. Epand
Publisher: CRC Press
ISBN: 9780849349263
Category : Medical
Languages : en
Pages : 422
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Book Description
The Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysics, and pharmacology.
Author: Thomas J. Dougherty
Publisher: Springer Science & Business Media
ISBN: 1461414008
Category : Medical
Languages : en
Pages : 1119
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Book Description
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Author: Padma V. Devarajan
Publisher: Springer
ISBN: 3319113550
Category : Medical
Languages : en
Pages : 788
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Book Description
This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Author: Alexander A. Vinks
Publisher: Springer Science & Business Media
ISBN: 0387756132
Category : Medical
Languages : en
Pages : 467
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Book Description
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
