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Author: Sarhan M. Musa
Publisher: CRC Press
ISBN: 1482230828
Category : Science
Languages : en
Pages : 437
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Book Description
Computational Optical Biomedical Spectroscopy and Imaging covers recent discoveries and research in the field by some of the best inventors and researchers in the world. It also presents useful computational methods and applications used in optical biomedical spectroscopy and imaging. Topics covered include:New trends in immunohistochemical, genome
Author: Sarhan M. Musa
Publisher: CRC Press
ISBN: 1482230828
Category : Science
Languages : en
Pages : 437
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Book Description
Computational Optical Biomedical Spectroscopy and Imaging covers recent discoveries and research in the field by some of the best inventors and researchers in the world. It also presents useful computational methods and applications used in optical biomedical spectroscopy and imaging. Topics covered include:New trends in immunohistochemical, genome
Author: Robert R. Alfano
Publisher: William Andrew
ISBN: 0323480683
Category : Technology & Engineering
Languages : en
Pages : 612
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Book Description
Neurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of diseases and other conditions, including pre-malignancy, cancer, Alzheimer’s disease, tissue and cell response to therapeutic intervention, unintended injury and laser energy deposition. The book then highlights research in neurophotonics that investigates single and multi-photon excitation optical signatures of normal/diseased nerve tissues and in the brain, providing a better understanding of the underlying biochemical and structural changes of tissues and cells that are responsible for the observed spectroscopic signatures. Topics cover a wide array of well-established UV, visible, NIR and IR optical and spectroscopic techniques and novel approaches to diagnose tissue changes, including: label free in vivo and ex vivo fluorescence spectroscopy, Stoke shift spectroscopy, spectral imaging, Resonance Raman spectroscopy, multiphoton two Photon excitation, and more. Provides an overview of the spectroscopic properties of tissue and tissue-light interaction, describing techniques to exploit these properties in imaging Explores the potential and significance of molecule-specific imaging and its capacity to reveal vital new information on nanoscale structures Offers a concise overview of different spectroscopic methods and their potential benefits for solving diagnostic and therapeutic problems
Author: James G. Fujimoto
Publisher: Oxford University Press
ISBN: 0199722293
Category : Science
Languages : en
Pages : 435
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Book Description
Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.
Author: David J. Brady
Publisher: John Wiley & Sons
ISBN: 0470443723
Category : Science
Languages : en
Pages : 530
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Book Description
An essential reference for optical sensor system design This is the first text to present an integrated view of the optical and mathematical analysis tools necessary to understand computational optical system design. It presents the foundations of computational optical sensor design with a focus entirely on digital imaging and spectroscopy. It systematically covers: Coded aperture and tomographic imaging Sampling and transformations in optical systems, including wavelets and generalized sampling techniques essential to digital system analysis Geometric, wave, and statistical models of optical fields The basic function of modern optical detectors and focal plane arrays Practical strategies for coherence measurement in imaging system design The sampling theory of digital imaging and spectroscopy for both conventional and emerging compressive and generalized measurement strategies Measurement code design Linear and nonlinear signal estimation The book concludes with a review of numerous design strategies in spectroscopy and imaging and clearly outlines the benefits and limits of each approach, including coded aperture and imaging spectroscopy, resonant and filter-based systems, and integrated design strategies to improve image resolution, depth of field, and field of view. Optical Imaging and Spectroscopy is an indispensable textbook for advanced undergraduate and graduate courses in optical sensor design. In addition to its direct applicability to optical system design, unique perspectives on computational sensor design presented in the text will be of interest for sensor designers in radio and millimeter wave, X-ray, and acoustic systems.
Author: Malgorzata Baranska
Publisher: Springer Science & Business Media
ISBN: 9400778325
Category : Science
Languages : en
Pages : 540
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Book Description
This multi-author contributed volume gives a comprehensive overview of recent progress in various vibrational spectroscopic techniques and chemometric methods and their applications in chemistry, biology and medicine. In order to meet the needs of readers, the book focuses on recent advances in technical development and potential exploitations of the theory, as well as the new applications of vibrational methods to problems of recent general interest that were difficult or even impossible to achieve in the not so distant past. Integrating vibrational spectroscopy and computational approaches serves as a handbook for people performing vibrational spectroscopy followed by chemometric analysis hence both experimental methods as well as procedures of recommended analysis are described. This volume is written for individuals who develop new methodologies and extend these applications to new realms of chemical and medicinal interest.
Author: Rongguang Liang
Publisher: Springer Science & Business Media
ISBN: 364228390X
Category : Science
Languages : en
Pages : 391
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Book Description
This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.
Author: Nikhil Mehta
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
This dissertation presents my work in application of computational techniques and the resulting enhancements to several non-linear and ultrafast optical imaging and spectroscopy modalities. The importance of novel computational optical imaging schemes which aim to overcome the limitations of conventional imaging techniques by leveraging the availability of computational resources and the vast body of literature in computational signal processing is emphasized. In particular the computational techniques of compressive sensing and two dimensional phase retrieval are introduced in the broad context as inversion techniques suitable for optical applications including coherent anti-Stokes Raman holography, non-linear spectroscopy, and ultrashort pulse characterization. It is shown that both computational techniques seek to improve key signal metrics such as higher signal to noise ratio (SNR) and better resolution than can be obtained traditionally within the specific imaging modality.Coherent anti-Stokes Raman scattering (CARS) holography is a novel imaging modality which combines the principles of coherent anti-Stokes Raman scattering and holography to provide label-free, chemical selective, scanning-free, and single shot 3D imaging modality. Compressive CARS holography is introduced as a sparsity constrained holographic image reconstruction technique to enhance the optical sectioning capability of CARS holography by suppressing out-of-focus background noise inherent in 3D images processed from a typical single 2D hologram. The advantages of compressive sensing guided signal acquisition strategy in optical spectroscopy is presented by proposing compressive multi-heterodyne optical spectroscopy as a novel technique for ultra-high resolution frequency comb spectroscopy. Using numerical simulations, our proposed compressive frequency comb spectroscopy technique is shown to be well-suited for recording narrow line spectra at ultra-high sampling over broad spectral range by leveraging sparsity inherent in such spectra.We next present applications of phase retrieval in optical imaging and spectroscopy. In particular we use 2D phase retrieval technique to enhance the resolution of sum frequency generation vibrational spectroscopy (SFG-VS) whose unique surface selectivity enables qualitative and quantitative study of chemical species at surfaces/interfaces. Specifically, our key contribution is that we show that our 2D phase retrieval based inversion algorithm enables measurement of characteristic molecular vibrational spectra of air/dimethyl sulfoxide interface at resolutions significantly better than that achievable in conventional SFG-VS acquisition system. Lastly, we address the limitation of the commonly used pulse characterization technique: frequency resolved optical gating (FROG) to spatio-temporally characterize the ultrafast pulse. Using a simple spectral holographic recording technique, we present a modified 2D phase retrieval based algorithm to measure the spectral phase at every spatial location in the vicinity of focus of an objective and thereby track the spatio-temporal evolution of the pulse along its optical axis.
Author: Lingyan Shi
Publisher: CRC Press
ISBN: 1351797387
Category : Medical
Languages : en
Pages : 444
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Book Description
The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Lihong V. Wang
Publisher: CRC Press
ISBN: 1420059920
Category : Science
Languages : en
Pages : 518
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Book Description
Photoacoustics promises to revolutionize medical imaging and may well make as dramatic a contribution to modern medicine as the discovery of the x-ray itself once did. Combining electromagnetic and ultrasonic waves synergistically, photoacoustics can provide deep speckle-free imaging with high electromagnetic contrast at high ultrasonic resolution and without any health risk. While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this book is the first comprehensive volume in this emerging field covering both the physics and the remarkable noninvasive applications that are changing diagnostic medicine. Bringing together the leading pioneers in this field to write about their own work, Photoacoustic Imaging and Spectroscopy is the first to provide a full account of the latest research and developing applications in the area of biomedical photoacoustics. Photoacoustics can provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. It can also provide high-contrast functional imaging of angiogenesis and hypermetabolism in tumors in vivo. Discussing these remarkable noninvasive applications and so much more, this reference is essential reading for all researchers in medical imaging and those clinicians working at the cutting-edge of modern biotechnology to develop diagnostic techniques that can save many lives and just as importantly do no harm.
