Computational Approaches for Ageing and Age-related diseases PDF Download
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Author: Stanley Durrleman
Publisher: Frontiers Media SA
ISBN: 2889767663
Category : Science
Languages : en
Pages : 140
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Book Description
Author: Stanley Durrleman
Publisher: Frontiers Media SA
ISBN: 2889767663
Category : Science
Languages : en
Pages : 140
Get Book Here
Book Description
Author: Handan Melike Donertas
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: A.I. Yashin
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318027308
Category : Medical
Languages : en
Pages : 208
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Book Description
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Author: Syed Ibrahim Rizvi
Publisher: Springer
ISBN: 9811316996
Category : Medical
Languages : en
Pages : 386
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Book Description
This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.
Author: Pramod C. Rath
Publisher: Springer
ISBN: 9811021554
Category : Medical
Languages : en
Pages : 358
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Book Description
This book presents a collection of articles on various aspects of current research on aging. These include model systems, cellular, biochemical and molecular aspects of experimental aging research, as well as selected intervention studies on age-related diseases. Aging is a global challenge to human society. Children are always in a hurry to become adults, while adults produce offspring and add to the gene pool. However, after adulthood or the attainment of reproductive maturity, all physiological parameters of the living organism start to undergo the aging process. Old age sets in slowly but surely, and usually continues for a prolonged period. If vigor and vitality are the main advantages of adulthood, old age offers the rewards of experience and maturity. Biologists ask questions such as: Why do we age? How do we become old? Is it possible to slow down, postpone or even prevent aging? In turn, medical experts ask: What are the diseases associated with old age? Are there medicines that can help affected elderly patients? In fact both groups are asking themselves how can we add more health to old age. Healthy aging is the dream of every individual. But to achieve this, it is fundamental that we first understand the cellular, biochemical and molecular basis of the aging process in mammalian cells, tissues and intact living organisms, which can serve as experimental model systems in Biomedical Gerontology. Once the biology of aging is understood at the genetic and molecular levels, interventional approaches to aging and its associated diseases may be easier to plan and implement at the preclinical level.
Author: Stephen Bondy
Publisher: Springer Science & Business Media
ISBN: 1607616025
Category : Medical
Languages : en
Pages : 468
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Book Description
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Author: Andrew Sixsmith
Publisher: Springer Science & Business Media
ISBN: 1441983481
Category : Family & Relationships
Languages : en
Pages : 232
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Book Description
The challenge of population aging requires innovative approaches to meet the needs of increasing numbers of older people. Emerging information and communication technologies (ICTs), such as pervasive computing and ambient assistive technology, have considerable potential for enhancing the quality of life of many older people by providing additional safety and security while also supporting mobility, independent living, and social participation. The proposed book will be a landmark publication in the area of technology and aging that will serve as a statement of the current state-of-the-art and as a pointer to directions for future research and emerging technologies, products, and services.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309091160
Category : Social Science
Languages : en
Pages : 321
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Book Description
Emerging and currently available technologies offer great promise for helping older adults, even those without serious disabilities, to live healthy, comfortable, and productive lives. What technologies offer the most potential benefit? What challenges must be overcome, what problems must be solved, for this promise to be fulfilled? How can federal agencies like the National Institute on Aging best use their resources to support the translation from laboratory findings to useful, marketable products and services? Technology for Adaptive Aging is the product of a workshop that brought together distinguished experts in aging research and in technology to discuss applications of technology to communication, education and learning, employment, health, living environments, and transportation for older adults. It includes all of the workshop papers and the report of the committee that organized the workshop. The committee report synthesizes and evaluates the points made in the workshop papers and recommends priorities for federal support of translational research in technology for older adults.
Author: Moshe Naveh-Benjamin
Publisher: Psychology Press
ISBN: 1136583017
Category : Psychology
Languages : en
Pages : 442
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Book Description
Current demographical patterns predict an aging worldwide population. It is projected that by 2050, more than 20% of the US population and 40% of the Japanese population will be older than 65. A dramatic increase in research on memory and aging has emerged to understand the age-related changes in memory since the ability to learn new information and retrieve previously learned information is essential for successful aging, and allows older adults to adapt to changes in their environment, self-concept, and social roles. This volume represents the latest psychological research on different aspects of age-related changes in memory. Written by a group of leading international researchers, its chapters cover a broad array of issues concerning the changes that occur in memory as people grow older, including the mechanisms and processes underlying these age-related memory changes, how these changes interact with social and cultural environments, and potential programs intended to increase memory performance in old age. Similarly, the chapters draw upon diverse methodological approaches, including cross-cultural extreme group experimental designs, longitudinal designs assessing intra-participant change, and computational approaches and neuroimaging assessment. Together, they provide converging evidence for stability and change in memory as people grow older, for the underlying causes of these patterns, as well as for the heterogeneity in older adults’ performance. Memory and Aging is essential reading for researchers in memory, cognitive aging, and gerontology.
Author: Gil Atzmon, PhD
Publisher: Springer
ISBN: 1493924044
Category : Medical
Languages : en
Pages : 199
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Book Description
The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.
