Computation in Cells and Tissues

Computation in Cells and Tissues PDF Author: R. Paton
Publisher: Springer Science & Business Media
ISBN: 3662063697
Category : Computers
Languages : en
Pages : 349

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Book Description
The field of biologically inspired computation has coexisted with mainstream computing since the 1930s, and the pioneers in this area include Warren McCulloch, Walter Pitts, Robert Rosen, Otto Schmitt, Alan Turing, John von Neumann and Norbert Wiener. Ideas arising out of studies of biology have permeated algorithmics, automata theory, artificial intelligence, graphics, information systems and software design. Within this context, the biomolecular, cellular and tissue levels of biological organisation have had a considerable inspirational impact on the development of computational ideas. Such innovations include neural computing, systolic arrays, genetic and immune algorithms, cellular automata, artificial tissues, DNA computing and protein memories. With the rapid growth in biological knowledge there remains a vast source of ideas yet to be tapped. This includes developments associated with biomolecular, genomic, enzymic, metabolic, signalling and developmental systems and the various impacts on distributed, adaptive, hybrid and emergent computation. This multidisciplinary book brings together a collection of chapters by biologists, computer scientists, engineers and mathematicians who were drawn together to examine the ways in which the interdisciplinary displacement of concepts and ideas could develop new insights into emerging computing paradigms. Funded by the UK Engineering and Physical Sciences Research Council (EPSRC), the CytoCom Network formally met on five occasions to examine and discuss common issues in biology and computing that could be exploited to develop emerging models of computation.

Computation in Cells and Tissues

Computation in Cells and Tissues PDF Author: R. Paton
Publisher: Springer Science & Business Media
ISBN: 3662063697
Category : Computers
Languages : en
Pages : 349

Get Book Here

Book Description
The field of biologically inspired computation has coexisted with mainstream computing since the 1930s, and the pioneers in this area include Warren McCulloch, Walter Pitts, Robert Rosen, Otto Schmitt, Alan Turing, John von Neumann and Norbert Wiener. Ideas arising out of studies of biology have permeated algorithmics, automata theory, artificial intelligence, graphics, information systems and software design. Within this context, the biomolecular, cellular and tissue levels of biological organisation have had a considerable inspirational impact on the development of computational ideas. Such innovations include neural computing, systolic arrays, genetic and immune algorithms, cellular automata, artificial tissues, DNA computing and protein memories. With the rapid growth in biological knowledge there remains a vast source of ideas yet to be tapped. This includes developments associated with biomolecular, genomic, enzymic, metabolic, signalling and developmental systems and the various impacts on distributed, adaptive, hybrid and emergent computation. This multidisciplinary book brings together a collection of chapters by biologists, computer scientists, engineers and mathematicians who were drawn together to examine the ways in which the interdisciplinary displacement of concepts and ideas could develop new insights into emerging computing paradigms. Funded by the UK Engineering and Physical Sciences Research Council (EPSRC), the CytoCom Network formally met on five occasions to examine and discuss common issues in biology and computing that could be exploited to develop emerging models of computation.

Computational Modeling in Tissue Engineering

Computational Modeling in Tissue Engineering PDF Author: Liesbet Geris
Publisher: Springer Science & Business Media
ISBN: 3642325637
Category : Technology & Engineering
Languages : en
Pages : 438

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Book Description
One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.

Information Processing in Cells and Tissues

Information Processing in Cells and Tissues PDF Author: Mike Holcombe
Publisher: Springer Science & Business Media
ISBN: 1461553458
Category : Medical
Languages : en
Pages : 325

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Book Description
Proceedings of an International Workshop held in Sheffield, UK, September 1-4, 1997

Modeling Excitable Tissue

Modeling Excitable Tissue PDF Author: Aslak Tveito
Publisher: Springer Nature
ISBN: 3030611574
Category : Mathematics
Languages : en
Pages : 116

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Book Description
This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.

Computing with Cells

Computing with Cells PDF Author: Pierluigi Frisco
Publisher: OUP Oxford
ISBN: 0191579637
Category : Mathematics
Languages : en
Pages : 368

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Book Description
Membrane systems are a new class of distributed and parallel model of computation inspired by the subdivision of living cells into compartments delimited by membranes. Their hierarchical internal structure, their locality of interactions, their inherent parallelism and also their capacity to create new compartments, represent the distinguishing hallmarks of membrane systems. Membrane computing, the study of membrane systems, is a fascinating and fast growing area of research. The main streams of current investigations in Membrane Computing concern theoretical computer science and the modelling of complex systems. In this monograph Pierluigi Frisco considers the former trend: he presents an in-depth study of the formal language and computational complexity aspects of the most widely investigated models of membrane systems. This study gives a comprehensive understanding of the computational power of the models considered, shows different proof techniques used for such study, and introduces links highlighting the similarities and differences between the their computational power. These models cover a broad range of features, giving a grasp of the enormous flexibility of the framework offered by membrane systems. Aimed at graduates and researchers in the field, who can use it as a reference text, and to people with an initial interest in Membrane Computing, who can use it as a clear and up to date starting point for Membrane Computing.

Computational Stem Cell Biology

Computational Stem Cell Biology PDF Author: Patrick Cahan
Publisher: Humana
ISBN: 9781493992232
Category : Science
Languages : en
Pages : 0

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Book Description
This volume details methods and protocols to further the study of stem cells within the computational stem cell biology (CSCB) field. Chapters are divided into four sections covering the theory and practice of modeling of stem cell behavior, analyzing single cell genome-scale measurements, reconstructing gene regulatory networks, and metabolomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Stem Cell Biology: Methods and Protocols will be an invaluable guide to researchers as they explore stem cells from the perspective of computational biology.

Methods and Models in Artificial and Natural Computation. A Homage to Professor Mira's Scientific Legacy

Methods and Models in Artificial and Natural Computation. A Homage to Professor Mira's Scientific Legacy PDF Author: Jose Mira
Publisher: Springer Science & Business Media
ISBN: 3642022634
Category : Computers
Languages : en
Pages : 550

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Book Description
The two-volume set LNCS 5601 and LNCS 5602 constitutes the refereed proceedings of the Third International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2009, held in Santiago de Compostela, Spain, in June 2009. The 108 revised papers presented are thematically divided into two volumes. The first volume includes papers relating the most recent collaborations with Professor Mira and contributions mainly related with theoretical, conceptual and methodological aspects linking AI and knowledge engineering with neurophysiology, clinics and cognition. The second volume contains all the contributions connected with biologically inspired methods and techniques for solving AI and knowledge engineering problems in different application domains.

Single-Cell-Based Models in Biology and Medicine

Single-Cell-Based Models in Biology and Medicine PDF Author: Alexander Anderson
Publisher: Springer Science & Business Media
ISBN: 376438123X
Category : Mathematics
Languages : en
Pages : 346

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Book Description
Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.

Methods and Applications of Computational Immunology

Methods and Applications of Computational Immunology PDF Author: Victor Greiff
Publisher: Frontiers Media SA
ISBN: 2889633888
Category :
Languages : en
Pages : 358

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Book Description


10th International Conference on Theory and Application of Soft Computing, Computing with Words and Perceptions - ICSCCW-2019

10th International Conference on Theory and Application of Soft Computing, Computing with Words and Perceptions - ICSCCW-2019 PDF Author: Rafik A. Aliev
Publisher: Springer Nature
ISBN: 3030352498
Category : Technology & Engineering
Languages : en
Pages : 997

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Book Description
This book presents the proceedings of the 10th Conference on Theory and Applications of Soft Computing, Computing with Words and Perceptions, ICSCCW 2019, held in Prague, Czech Republic, on August 27–28, 2019. It includes contributions from diverse areas of soft computing and computing with words, such as uncertain computation, decision-making under imperfect information, neuro-fuzzy approaches, deep learning, natural language processing, and others. The topics of the papers include theory and applications of soft computing, information granulation, computing with words, computing with perceptions, image processing with soft computing, probabilistic reasoning, intelligent control, machine learning, fuzzy logic in data analytics and data mining, evolutionary computing, chaotic systems, soft computing in business, economics and finance, fuzzy logic and soft computing in earth sciences, fuzzy logic and soft computing in engineering, fuzzy logic and soft computing in material sciences, soft computing in medicine, biomedical engineering, and pharmaceutical sciences. Showcasing new ideas in the field of theories of soft computing and computing with words and their applications in economics, business, industry, education, medicine, earth sciences, and other fields, it promotes the development and implementation of these paradigms in various real-world contexts. This book is a useful guide for academics, practitioners and graduates.