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Languages : en
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Author: Akio Inui
Publisher: Frontiers Media SA
ISBN: 2889637611
Category :
Languages : en
Pages : 325
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Book Description
Author: Mohamed Al-Rubeai
Publisher: Springer Science & Business Media
ISBN: 9048122457
Category : Medical
Languages : en
Pages : 259
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Book Description
Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms. This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout.
Author: Ricardo Silvestre
Publisher: Springer
ISBN: 3319749323
Category : Science
Languages : en
Pages : 478
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Book Description
This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.
Author: Edward R.(Ted) Farnworth
Publisher: CRC Press
ISBN: 020300972X
Category : Technology & Engineering
Languages : en
Pages : 408
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Book Description
Fermented foods have been an important part of the human diet in many cultures for many centuries. Modern research, especially on the immune system, is revealing how these foods and their active ingredients impact human health. Handbook of Fermented Functional Foods presents the latest data on fermented food products, their production processes, an
Author: M. H. Fulekar
Publisher: Springer Science & Business Media
ISBN: 1402088809
Category : Science
Languages : en
Pages : 254
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Book Description
Bioinformatics, computational biology, is a relatively new field that applies computer science and information technology to biology. In recent years, the discipline of bioinformatics has allowed biologists to make full use of the advances in Computer sciences and Computational statistics for advancing the biological data. Researchers in life sciences generate, collect and need to analyze an increasing number of different types of scientific data, DNA, RNA and protein sequences, in-situ and microarray gene expression including 3D protein structures and biological pathways. This book is aiming to provide information on bioinformatics at various levels. The chapters included in this book cover introductory to advanced aspects, including applications of various documented research work and specific case studies related to bioinformatics. This book will be of immense value to readers of different backgrounds such as engineers, scientists, consultants and policy makers for industry, government, academics and social and private organisations.
Author: Wolfgang R. Streit
Publisher: Methods in Molecular Biology
ISBN: 9781493982745
Category : Medical
Languages : en
Pages : 320
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Book Description
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309465184
Category : Technology & Engineering
Languages : en
Pages : 189
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Book Description
Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Author: Central Intelligence Agency
Publisher: Hassell Street Press
ISBN: 9781014024183
Category :
Languages : en
Pages : 28
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Book Description
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author: Carl L. Davis
Publisher: Iowa State Press
ISBN: 9780813829807
Category : Nature
Languages : en
Pages : 339
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Book Description
An indispensable resource for the dairy farmer or veterinarian, the researcher, teacher, or advanced student, this book puts the cutting–edge science of raising dairy calves into an accessible, usable form. Geared to those with a basic understanding of principles of animal nutrition and husbandry, the volume gives a comprehensive account of all aspects of calf rearing, from the rudiments of anatomy and development through the practicalities of feeding and housing. The Development, Nutrition and Management of the Young Calf begins with an overview of how the calf′s digestive system develops, highlighting the period of transition from preruminant to ruminant digestion. Here the authors provide information essential to understanding nutritional needs and restrictions during the liquid–feeding phase in the young calf as well as those factors that govern the development of a functional rumen. Major emphasis is given to the energy and protein requirements of the young calf, with attention to the effects of environmental temperature on energy requirements. The authors also review the adequacy of current National Research Council recommendations on the energy and protein requirements of young calves. They discuss the management, nutrition, and care of the pregnant cow as well as calving management necessary to deliver a healthy calf. Other topics include liquid–feeding systems, formulation and use of milk replacers and starter feeds, the weaning process, housing principles, and the interactions of nutrition and disease
