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Author:
Publisher: Academic Press
ISBN: 0123814308
Category : Science
Languages : en
Pages : 167
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Book Description
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Author:
Publisher: Academic Press
ISBN: 0123814308
Category : Science
Languages : en
Pages : 167
Get Book Here
Book Description
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Author:
Publisher: Academic Press
ISBN: 9780123814296
Category : Science
Languages : en
Pages : 350
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Book Description
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Author: Saverio Bettuzzi
Publisher: Academic Press
ISBN: 0123747724
Category : Apoptosis
Languages : en
Pages : 234
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Book Description
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. In this Part A volume, outstanding and original reviews provide an overview and synthesis of the latest thoughts and findings relating to Clusterin. Chapters include the shifiting balance between CLU Forms during tumor progression, uclear CLU and the fate of the cell, and Oxidative stress in malignant progression.
Author: Saverio Bettuzzi
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author:
Publisher: Academic Press
ISBN: 9780123747723
Category : Science
Languages : en
Pages : 350
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Book Description
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Author: Davide Moretti
Publisher:
ISBN: 9789535126553
Category : Alzheimer's disease
Languages : en
Pages :
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Book Description
"The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities."--Provided by publisher
Author:
Publisher: Elsevier
ISBN: 0080497063
Category : Science
Languages : en
Pages : 664
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Book Description
Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covers the wide area of methodology of carbohydrate recognition. This volume, Recognition of Carbohydrates in Biological Systems, Part B: Specific Applications, and its companion, Volume 362, present state-of-the-art methodologies, as well as the most recent biological observations in this area. Covers carbohydrate-binding proteins Discusses glycoproteins and glycolipids Polysaccharides, enzymes and cells are also covered
Author: A.D. Roses
Publisher: Springer Science & Business Media
ISBN: 3642801099
Category : Medical
Languages : en
Pages : 208
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Book Description
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
Author: Bela Bollobas
Publisher: Springer Science & Business Media
ISBN: 3540693955
Category : Mathematics
Languages : en
Pages : 600
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Book Description
With the advent of digital computers more than half a century ago, - searchers working in a wide range of scienti?c disciplines have obtained an extremely powerful tool to pursue deep understanding of natural processes in physical, chemical, and biological systems. Computers pose a great ch- lenge to mathematical sciences, as the range of phenomena available for rigorous mathematical analysis has been enormously expanded, demanding the development of a new generation of mathematical tools. There is an explosive growth of new mathematical disciplines to satisfy this demand, in particular related to discrete mathematics. However, it can be argued that at large mathematics is yet to provide the essential breakthrough to meet the challenge. The required paradigm shift in our view should be compa- ble to the shift in scienti?c thinking provided by the Newtonian revolution over 300 years ago. Studies of large-scale random graphs and networks are critical for the progress, using methods of discrete mathematics, probabil- tic combinatorics, graph theory, and statistical physics. Recent advances in large scale random network studies are described in this handbook, which provides a signi?cant update and extension - yond the materials presented in the “Handbook of Graphs and Networks” published in 2003 by Wiley. The present volume puts special emphasis on large-scale networks and random processes, which deemed as crucial for - tureprogressinthe?eld. Theissuesrelatedtorandomgraphsandnetworks pose very di?cult mathematical questions.
Author: Altuna Akalin
Publisher: CRC Press
ISBN: 1498781861
Category : Mathematics
Languages : en
Pages : 462
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Book Description
Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.
