Clinical and Experimental Studies on the Cellular Mediators of Corneal Allograft Rejection PDF Download
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Author: Thomas Henry Flynn
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Category :
Languages : en
Pages : 0
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Author: Thomas Henry Flynn
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: T. H. Flynn
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Category :
Languages : en
Pages :
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Despite significant advances in our knowledge of the cellular and molecular elements of transplant immunology the 10 year survival probability for all human corneal grafts is 0.73. In some "high-risk" recipients it is as low as 0.37. To date almost all our knowledge about the cellular events during acute corneal graft rejection comes from animal models. In mice, the presence of pre-existing host corneal vascularisation confers "high-risk" status on a graft and has been shown to accelerate rejection. In the first part of this thesis the effect on survival of grafting to an inflamed conjunctival bed was investigated. Using a mouse model of allergic conjunctivitis significantly reduced survival was seen in graft recipients with perioperative conjunctival inflammation. This appeared to be due to the local effects of conjunctivitis rather than systemic effects of allergy/ atopy. Subsequent experiments investigated the effect of perioperative allergic conjunctivitis on the cellular components of both early (surgical trauma-induced, alloantigen-independent) and late (alloantigen-dependent; rejection) post-keratoplasty anterior segment inflammation and demonstrated significant effects on both. Grafts recipients with allergic conjunctivitis had significantly greater early post-operative corneal inflammation and associated corneal and conjunctival lymphangiogenesis. Analysis of graft infiltrating cells during rejection in mice confirmed that large numbers of CD4+ cells, CD8+ cells and macrophages were recruited. Flow cytometric analysis of human aqueous during acute endothelial rejection demonstrated for the first time the presence of CD4+ cells, CD8+ cells and a surprisingly high proportion of macrophages therein. In mouse recipients with allergic conjunctivitis eosinophils were found in both the graft itself and the ciliary body during rejection although the role of these cells during rejection is uncertain. Chemokine analysis during both murine and human corneal graft rejection demonstrated increased expression of the chemokine IP-10 (CXCL-10) suggesting a potentially important role for this protein in the rejection process.
Author:
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Category : Medicine
Languages : en
Pages : 742
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Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: National Institutes of Health (U.S.). Division of Research Grants
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1224
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Author: R.P. Lanza
Publisher: Springer Science & Business Media
ISBN: 9400901658
Category : Science
Languages : en
Pages : 280
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Cell and tissue transplantation is one of the most exciting and rapidly expanding areas in medicine. This first edition of the Yearbook of Cell and Tissue Transplantation summarizes the latest advances in this revolutionary field, including developments in tissue engineering and transplantation of hybrid organs and tissues, while reviewing those data which, while not new, add to the usefulness of this work as a comprehensive reference. The justification for yearbooks is greater than ever as we approach the third millennium, overwhelmed with information. In view of the important and rapid changes occurring in this area, a new edition of this yearbook will appear periodically. The editors' careers at Harvard Medical School guarantee the quality of this book. The authors, too, are uniformly drawn from the highest rank of an unusually dedicated and heterogeneous professional group. from the Foreword by Thomas E. Starzl, Honorary President, The Cell Transplant Society: `No major topic in the global field is left uncovered ... the result will be a feast for those already well informed, and a life raft for those who are not.'
Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1060
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Author: Djordje Miljkovic
Publisher: Frontiers Media SA
ISBN: 2889716465
Category : Medical
Languages : en
Pages : 411
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Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1192
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Author:
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ISBN:
Category : Ophthalmology
Languages : en
Pages : 740
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