Author: Suleyman Vural
Publisher:
ISBN:
Category :
Languages : en
Pages : 100
Get Book Here
Book Description
The high degree of heterogeneity observed in breast cancers makes it very difficult to classify cancer patients into distinct clinical subgroups and consequently limits the ability to devise effective therapeutic strategies. In this study, we explore the use of gene mutation profiles to classify, characterize and predict the subgroups of breast cancers. We analyzed the whole exome sequencing data from 358 ethnically similar breast cancer patients in The Cancer Genome Atlas (TCGA) project. Identified somatic and non-synonymous single nucleotide variants were assigned a quantitative score (C-score) that represents the extent of negative impact on the function of the gene. Using these scores with a non-negative matrix factorization method, we clustered the patients into three subgroups. By comparing the clinical stage of patients among the three subgroups, we identified an early-stage-enriched and a late-stage-enriched subgroup. Comparison of the C-scores (mutation scores) of these subgroups identified 358 genes that carry significantly higher rates of mutations in the late-stage-enriched subgroup. Functional characterization of these genes revealed important functional gene families that carry a heavy mutational load in the late-state-enriched subgroup. Finally, using the identified subgroups, we also developed a supervised classification model to predict the likely stage of patients, given their mutation profiles, hence provide clinical insights to help devise an effective treatment plan. This study demonstrates that gene mutation profiles can be effectively used with machine-learning methods to identify clinically distinguishable subgroups of cancer patients. Genes and gene families that carry a heavy mutational load in late-stage-enriched cancer patients compared to early-stage-enriched subgroup were also identified from functional analysis of genes. The classification model developed in this method could provide a reasonable prediction of the stage of cancer patients solely based on their mutation profiles. This study represents the first use of only somatic mutation profile data to identify and predict breast cancer subgroups and this generic methodology could also be applied to other cancer datasets.
Author: Akor Ugwu
Publisher: GRIN Verlag
ISBN: 334640482X
Category : Medical
Languages : en
Pages : 77
Get Book Here
Book Description
Diploma Thesis from the year 2020 in the subject Medicine - Diagnostics, grade: 3.55, , course: Computer Science, language: English, abstract: The study will classify breast cancers into foremost problems: (Benign tumor and Malignant tumor). A benign tumor is a most cancers does now not invade its surrounding tissue or spread around the host. A malignant tumor is another kind of cancers which can invade its surrounding tissue or spread around the frame of the host. Benign cancers on uncommon event can also surely result in someone’s death, but as a fashionable rule they're no longer nearly as horrific because the malignant cancers. The malignant cancers at the contrary are like those killer bees. In this situation, you do not need to be doing something to them or maybe be everywhere near their hive, they will just spread out and attack you emass – they could even kill the individual if they are extreme enough. Manual manner of cancer category into benign and malignant may be very tedious, susceptible to human error and unnecessarily time consuming. The proposed system while constructed can robotically classify the sort of most cancers into the safe (benign) and also the risky (malignant). This machine plays this role through the usage of machine getting to know algorithm. The following is the extensive of this new system: Classification mistakes could be notably removed, early analysis of disorder, removal of possible human mistakes and the device does no longer die. However, the researcher seeks to detect and assess the class of breast using Machine learning.
Author: David D. Luxton
Publisher: Academic Press
ISBN: 0128007923
Category : Psychology
Languages : en
Pages : 309
Get Book Here
Book Description
Artificial Intelligence in Behavioral and Mental Health Care summarizes recent advances in artificial intelligence as it applies to mental health clinical practice. Each chapter provides a technical description of the advance, review of application in clinical practice, and empirical data on clinical efficacy. In addition, each chapter includes a discussion of practical issues in clinical settings, ethical considerations, and limitations of use. The book encompasses AI based advances in decision-making, in assessment and treatment, in providing education to clients, robot assisted task completion, and the use of AI for research and data gathering. This book will be of use to mental health practitioners interested in learning about, or incorporating AI advances into their practice and for researchers interested in a comprehensive review of these advances in one source. - Summarizes AI advances for use in mental health practice - Includes advances in AI based decision-making and consultation - Describes AI applications for assessment and treatment - Details AI advances in robots for clinical settings - Provides empirical data on clinical efficacy - Explores practical issues of use in clinical settings
Author: Chad Brenner
Publisher: MDPI
ISBN: 3039217887
Category : Medical
Languages : en
Pages : 418
Get Book Here
Book Description
This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.
Author: Ravi Salgia
Publisher: Springer
ISBN: 3030178323
Category : Medical
Languages : en
Pages : 238
Get Book Here
Book Description
This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
Author: Min Tang
Publisher: Frontiers Media SA
ISBN: 2889666549
Category : Science
Languages : en
Pages : 257
Get Book Here
Book Description
Author: Cha Zhang
Publisher: Springer Science & Business Media
ISBN: 1441993258
Category : Computers
Languages : en
Pages : 332
Get Book Here
Book Description
It is common wisdom that gathering a variety of views and inputs improves the process of decision making, and, indeed, underpins a democratic society. Dubbed “ensemble learning” by researchers in computational intelligence and machine learning, it is known to improve a decision system’s robustness and accuracy. Now, fresh developments are allowing researchers to unleash the power of ensemble learning in an increasing range of real-world applications. Ensemble learning algorithms such as “boosting” and “random forest” facilitate solutions to key computational issues such as face recognition and are now being applied in areas as diverse as object tracking and bioinformatics. Responding to a shortage of literature dedicated to the topic, this volume offers comprehensive coverage of state-of-the-art ensemble learning techniques, including the random forest skeleton tracking algorithm in the Xbox Kinect sensor, which bypasses the need for game controllers. At once a solid theoretical study and a practical guide, the volume is a windfall for researchers and practitioners alike.
Author: V. Sivakumar Reddy
Publisher: Springer Nature
ISBN: 9811612498
Category : Technology & Engineering
Languages : en
Pages : 663
Get Book Here
Book Description
This book presents selected research papers on current developments in the fields of soft computing and signal processing from the Third International Conference on Soft Computing and Signal Processing (ICSCSP 2020). The book covers topics such as soft sets, rough sets, fuzzy logic, neural networks, genetic algorithms and machine learning and discusses various aspects of these topics, e.g., technological considerations, product implementation and application issues.
Author: J. Jost
Publisher: Birkhäuser
ISBN: 3034891180
Category : Science
Languages : en
Pages : 581
Get Book Here
Book Description
The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see first chapter). Recognition of its possible physiologi cal role in eucaryotes was first suggested in 1964 by Srinivasan and Borek (see first chapter). Since then work in a great many laboratories has established both the ubiquity of 5-methylcytosine and the catholicity of its possible regulatory function. The explosive increase in the number of publications dealing with DNA methylation attests to its importance and makes it impossible to write a comprehensive coverage of the literature within the scope of a general review. Since the publication of the 3 most recent books dealing with the subject (DNA methylation by Razin A. , Cedar H. and Riggs A. D. , 1984 Springer Verlag; Molecular Biology of DNA methylation by Adams R. L. P. and Burdon R. H. , 1985 Springer Verlag; Nucleic Acids Methylation, UCLA Symposium suppl. 128, 1989) considerable progress both in the techniques and results has been made in the field of DNA methylation. Thus we asked several authors to write chapters dealing with aspects of DNA methyla tion in which they are experts. This book should be most useful for students, teachers as well as researchers in the field of differentiation and gene regulation. We are most grateful to all our colleagues who were willing to spend much time and effort on the publication of this book. We also want to express our gratitude to Yan Chim Jost for her help in preparing this book.
Author: Linqiang Pan
Publisher: Springer
ISBN: 3662450496
Category : Computers
Languages : en
Pages : 690
Get Book Here
Book Description
This book constitutes the proceedings of the 9th International Conference on Bio-inspired Computing: Theories and Applications, BIC-TA 2014, held in Wuhan, China, in October 2014. The 109 revised full papers presented were carefully reviewed and selected from 204 submissions. The papers focus on four main topics, namely evolutionary computing, neural computing, DNA computing, and membrane computing.
